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Cystic fibrosis: the latest breakthroughs

Everything that changed in the last year, from three public sources: phase 3 trials that posted their results, papers in the leading medical and cancer journals, and US drug labels that were updated. Refreshed every week.

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What changed

Written by AI from the evidence below, every point cited

AI reads the results, papers and label updates below and explains what changed and why it matters, citing each source. It is shared with everyone.

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Phase 3 results posted

The large trials that decide new standard treatments · ClinicalTrials.gov
Evaluation of Elexacaftor/Tezacaftor/Ivacaftor (ELX/TEZ/IVA) in Cystic Fibrosis (CF) Participants 12 to Less Than 24 Months of AgeNCT05882357 · results posted 2026-10-15 · Vertex Pharmaceuticals Incorporated · 67 people · tests ELX/TEZ/IVA, IVA SGLT2 Inhibitor Therapy in Cystic Fibrosis-related DiabetesNCT06149793 · results posted 2026-09-21 · University of Minnesota · 8 people · tests Empagliflozin, Placebo Control Sildenafil Exercise: Role of PDE5 InhibitionNCT04039087 · results posted 2026-08-28 · National Jewish Health · 31 people · tests Sildenafil 40mg oral capsule, Placebo Oral capsule Semaglutide in CFRDNCT05788965 · results posted 2026-01-21 · University of Minnesota · 8 people · tests Semaglutide A Study to Assess the Efficacy, Safety, and Tolerability of Brensocatib in Participants With Non-Cystic Fibrosis BronchiectasisNCT04594369 · results posted 2025-12-16 · Insmed Incorporated · 1767 people · tests Brensocatib 10 mg, Brensocatib 25 mg, Placebo

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