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๐Ÿ“ฐ Latest breakthroughs
๐Ÿ—บ๏ธ Disease Atlas ยท Nervous system disorder

parkinsonian-pyramidal syndrome

A Parkinson's disease that has material basis in mutation in the FBXO7 gene on chromosome 22q12.3.

๐Ÿ”” Follow weekly
๐Ÿงฌ348genes / proteins with evidence
๐Ÿ’Š0drugs and clinical candidates
๐Ÿงช1recruiting trials worldwide
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Understand parkinsonian-pyramidal syndrome

Brain and nerves ยท Nerve cells that slowly stop working
๐ŸŽ“ Learn more

What it is

A Parkinson's disease that has material basis in mutation in the FBXO7 gene on chromosome 22q12.3.

From the Open Targets disease record โ†—

๐Ÿง  Brain and nerves: In neurodegenerative diseases, nerve cells in the brain or spinal cord stop working and die over time - affecting memory (Alzheimer's disease), movement (Parkinson's disease) or muscles (ALS).

โ“ Why it happens

  • Proteins fold the wrong way and clump together inside or between nerve cells - amyloid and tau in Alzheimer's disease, alpha-synuclein in Parkinson's disease.
  • Inflammation, some genes (such as APOE4) and, above all, age raise the risk.

๐Ÿซ€ What it does to the body

  • As connections between nerve cells are lost, memory, thinking, movement or speech fade.
  • The changes start years - often decades - before the first symptoms.

๐Ÿงฑ Why it is hard to cure

  • Most medicines cannot easily pass the blood-brain barrier that protects the brain.
  • By the time symptoms appear, many nerve cells are already lost, and they do not grow back.
  • Many drug trials have failed, partly because the diseases are found late.

๐Ÿš€ What research is trying now

  • Antibodies that clear amyloid and modestly slow early Alzheimer's disease (approved in some countries).
  • Blood tests that detect Alzheimer's changes years earlier.
  • Gene-targeted medicines, such as one approved in the US for an inherited form of ALS.

General information about brain and nerves, reviewed by people; it does not describe any one person. Below: the evidence for parkinsonian-pyramidal syndrome itself.

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AI briefing

Where the science on parkinsonian-pyramidal syndrome stands, from the evidence on this page

AI reads the targets, drugs, trials and papers below and writes where the science stands โ€” every claim cited. It is shared with everyone who opens parkinsonian-pyramidal syndrome.

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Top targets

Genes and proteins ranked by Open Targets evidence (0-1)
FBXO7 F-box protein 7PROTAC๐ŸงŠ AlphaFold structure โ†— 0.75
SNCA synuclein alphaPROTACantibodysmall molecule๐ŸงŠ AlphaFold structure โ†— 0.37
GLRA1 glycine receptor alpha 1PROTACantibodysmall molecule๐ŸงŠ AlphaFold structure โ†— 0.08
GLRB glycine receptor betaPROTACantibodysmall molecule๐ŸงŠ AlphaFold structure โ†— 0.08
SCN8A sodium voltage-gated channel alpha subunit 8PROTACantibodysmall molecule๐ŸงŠ AlphaFold structure โ†— 0.08
SPTBN4 spectrin beta, non-erythrocytic 4PROTACantibody๐ŸงŠ AlphaFold structure โ†— 0.07
PMP22 peripheral myelin protein 22PROTACantibodysmall molecule๐ŸงŠ AlphaFold structure โ†— 0.07
DST dystoninPROTACantibody๐ŸงŠ AlphaFold structure โ†— 0.07
MYO5A myosin VAPROTACsmall molecule๐ŸงŠ AlphaFold structure โ†— 0.07
SLC6A5 solute carrier family 6 member 5PROTACantibodysmall molecule๐ŸงŠ AlphaFold structure โ†— 0.07
CACNA1A calcium voltage-gated channel subunit alpha1 APROTACantibodysmall molecule๐ŸงŠ AlphaFold structure โ†— 0.07
MBP myelin basic proteinPROTACantibody๐ŸงŠ AlphaFold structure โ†— 0.07
CSTB cystatin BPROTACantibody๐ŸงŠ AlphaFold structure โ†— 0.07
ATP2B2 ATPase plasma membrane Ca2+ transporting 2PROTACantibodysmall molecule๐ŸงŠ AlphaFold structure โ†— 0.07
QKI QKI, KH domain containing RNA bindingPROTAC๐ŸงŠ AlphaFold structure โ†— 0.07

Green labels: what the target is known to be druggable by. The score combines genetics, somatic mutations, drugs, expression and literature.

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Drugs and candidates

Every medicine linked to parkinsonian-pyramidal syndrome, by how far it has got

No drugs recorded yet.

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AI Cure shows public evidence (Open Targets, ClinicalTrials.gov, PubMed, openFDA, DepMap, AlphaFold) with its source, and AI summaries that cite it โ€” not medical advice and not a cure. Treatment decisions belong with your doctor. Research ideas are shared only with approved researchers and labs, who can test them. In an emergency call your local emergency number (112 in India and Europe, 911 in the US). AI Cure Terms of Use ยท Privacy