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🗺️ Disease Atlas · Nervous system disorder

Alzheimer disease 3

Alzheimer's disease with an early onset (starts before the age of 65). It is caused by mutations in the PSEN1 gene.

🔔 Follow weekly
🧬695genes / proteins with evidence
💊0drugs and clinical candidates
🧪12+recruiting trials worldwide
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Understand Alzheimer disease 3

Brain and nerves · Nerve cells that slowly stop working
🎓 Learn more

What it is

Progressive supranuclear palsy (PSP) is a rare brain disease. It happens because of damage to nerve cells in the brain. PSP affects your movement, including control of your walking and balance. It also affects your thinking and eye movement.

PSP is progressive, which means that it gets worse over time.

What causes progressive supranuclear palsy (PSP)?

From MedlinePlus: Progressive Supranuclear Palsy (US National Library of Medicine) ↗

🧠 Brain and nerves: In neurodegenerative diseases, nerve cells in the brain or spinal cord stop working and die over time - affecting memory (Alzheimer's disease), movement (Parkinson's disease) or muscles (ALS).

❓ Why it happens

  • Proteins fold the wrong way and clump together inside or between nerve cells - amyloid and tau in Alzheimer's disease, alpha-synuclein in Parkinson's disease.
  • Inflammation, some genes (such as APOE4) and, above all, age raise the risk.

🫀 What it does to the body

  • As connections between nerve cells are lost, memory, thinking, movement or speech fade.
  • The changes start years - often decades - before the first symptoms.

🧱 Why it is hard to cure

  • Most medicines cannot easily pass the blood-brain barrier that protects the brain.
  • By the time symptoms appear, many nerve cells are already lost, and they do not grow back.
  • Many drug trials have failed, partly because the diseases are found late.

🚀 What research is trying now

  • Antibodies that clear amyloid and modestly slow early Alzheimer's disease (approved in some countries).
  • Blood tests that detect Alzheimer's changes years earlier.
  • Gene-targeted medicines, such as one approved in the US for an inherited form of ALS.

General information about brain and nerves, reviewed by people; it does not describe any one person. Below: the evidence for Alzheimer disease 3 itself.

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AI briefing

Where the science on Alzheimer disease 3 stands, from the evidence on this page

AI reads the targets, drugs, trials and papers below and writes where the science stands — every claim cited. It is shared with everyone who opens Alzheimer disease 3.

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Top targets

Genes and proteins ranked by Open Targets evidence (0-1)
PSEN1 presenilin 1PROTACantibodysmall molecule🧊 AlphaFold structure ↗ 0.84
APOE apolipoprotein EPROTACantibodysmall molecule🧊 AlphaFold structure ↗ 0.33
CACNA1A calcium voltage-gated channel subunit alpha1 APROTACantibodysmall molecule🧊 AlphaFold structure ↗ 0.08
SCN8A sodium voltage-gated channel alpha subunit 8PROTACantibodysmall molecule🧊 AlphaFold structure ↗ 0.08
RELN reelinPROTACantibody🧊 AlphaFold structure ↗ 0.08
MYO5A myosin VAPROTACsmall molecule🧊 AlphaFold structure ↗ 0.08
PRNP prion protein (Kanno blood group)PROTACantibodysmall molecule🧊 AlphaFold structure ↗ 0.08
GLRA1 glycine receptor alpha 1PROTACantibodysmall molecule🧊 AlphaFold structure ↗ 0.08
PMP22 peripheral myelin protein 22PROTACantibodysmall molecule🧊 AlphaFold structure ↗ 0.07
GRID2 glutamate ionotropic receptor delta type subunit 2antibodysmall molecule🧊 AlphaFold structure ↗ 0.07
MECP2 methyl-CpG binding protein 2PROTAC🧊 AlphaFold structure ↗ 0.07
ATP2B2 ATPase plasma membrane Ca2+ transporting 2PROTACantibodysmall molecule🧊 AlphaFold structure ↗ 0.07
ZNF423 zinc finger protein 423PROTAC🧊 AlphaFold structure ↗ 0.07
SPTBN4 spectrin beta, non-erythrocytic 4PROTACantibody🧊 AlphaFold structure ↗ 0.07
GLRB glycine receptor betaPROTACantibodysmall molecule🧊 AlphaFold structure ↗ 0.07

Green labels: what the target is known to be druggable by. The score combines genetics, somatic mutations, drugs, expression and literature.

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Drugs and candidates

Every medicine linked to Alzheimer disease 3, by how far it has got

No drugs recorded yet.

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Recruiting trials

Worldwide, open to new patients now
A Study to Evaluate Safety and Efficacy of KarXT + KarX-EC as a Treatment for Psychosis Associated With Alzhe…NCT06947941 · Phase 3 · 📍 GilbertA Study to Evaluate the Efficacy and Safety of KarXT + KarX-EC for Cognitive Impairment in Alzheimer's Diseas…NCT06976203 · Phase 3 · 📍 FullertonA Study of Donanemab, RG6289, or the Combination of Donanemab and RG6289 in Presenilin 1 (PSEN1) E280A Mutati…NCT06996730 · Phase 2, Phase 3 · 📍 MedellínA Trial Evaluating the Effect of NIO752 on Tau Synthesis Measured by a Process Known as SILKNCT06372821 · Phase 1 · 📍 St LouisA Study to Evaluate the Efficacy and Safety of KarXT + KarX-EC for Cognitive Impairment in Alzheimer's DiseaseNCT06976216 · Phase 3 · 📍 Long BeachAdapting RDAD for DSNCT07425769 · NA · 📍 Kansas CityA Study to Evaluate KarXT as a Treatment for Psychosis Associated With Alzheimer's Disease (ADEPT-4)NCT06585787 · Phase 3 · 📍 ChandlerPhase 3 Clinical Trial of Wujia Yizhi Granules in the Treatment of Mild-to-moderate Alzheimer's Dementia (Syn…NCT06534723 · Phase 3 · 📍 FuzhouA Study to Evaluate the Long-term Efficacy and Safety of KarXT + KarX-EC for Agitation in Alzheimer's Disease…NCT06937229 · Phase 3 · 📍 ChandlerA Phase 3 Study of Rotigotine in Combination with Rivastigmine in Mild to Moderate Alzheimer's DiseaseNCT06702124 · Phase 3 · 📍 RomeStudy to Evaluate the Efficacy, Safety, and Tolerability of BMS-986368, for the Treatment of Agitation in Par…NCT06808984 · Phase 2 · 📍 HomewoodA Phase 3 Study to Evaluate the Safety and Efficacy of KarXT + KarX-EC for the Treatment of Agitation Associa…NCT07011745 · Phase 3 · 📍 Chandler Search more trials →
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