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🗺️ Disease Atlas · Genetic, familial or congenital disease

colorectal cancer, susceptibility to, 1

Any colorectal cancer in which the cause of the disease is a mutation in the GALNT12 gene.

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🧬11genes / proteins with evidence
💊0drugs and clinical candidates
🧪1recruiting trials worldwide
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Understand colorectal cancer, susceptibility to, 1

Cancer · Cells that grow out of control
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What it is

Any colorectal cancer in which the cause of the disease is a mutation in the GALNT12 gene.

From the Open Targets disease record ↗

🧬 Cancer: Cancer is a group of diseases in which some of the body's cells grow and divide without control, and can spread to other parts of the body.

❓ Why it happens

  • Changes (mutations) build up in the genes that tell a cell when to grow, divide and die.
  • Most of these changes happen during life: tobacco, too much sun, alcohol, some infections (such as HPV and hepatitis B and C), radiation, obesity and ageing all raise the risk.
  • Some people inherit a faulty gene that raises their risk, such as BRCA1 or BRCA2.

🫀 What it does to the body

  • Cancer cells form a lump (tumour) that can press on or invade nearby organs.
  • They can travel through the blood or lymph to start new tumours elsewhere (metastasis).
  • Blood cancers crowd out healthy blood cells in the bone marrow.

🧱 Why it is hard to cure

  • Every cancer is different, even between two people with the same type - and inside one tumour.
  • Cancer cells keep changing, so they can learn to resist a medicine that worked at first.
  • Cancer cells are the body's own cells, so killing them without harming healthy cells is hard.
  • Many cancers cause no symptoms until they have spread, and a new medicine often takes more than ten years to go from the lab to patients.

🚀 What research is trying now

  • Targeted medicines against the exact gene change in a tumour (for example EGFR, ALK or KRAS).
  • Immunotherapy that helps the immune system recognise cancer, including CAR-T cell therapy.
  • Personalised cancer vaccines built from each tumour's mutations, now in late trials.
  • Blood tests that look for tumour DNA to find cancer earlier, and AI to read scans and slides.

General information about cancer, reviewed by people; it does not describe any one person. Below: the evidence for colorectal cancer, susceptibility to, 1 itself.

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AI briefing

Where the science on colorectal cancer, susceptibility to, 1 stands, from the evidence on this page

AI reads the targets, drugs, trials and papers below and writes where the science stands — every claim cited. It is shared with everyone who opens colorectal cancer, susceptibility to, 1.

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Top targets

Genes and proteins ranked by Open Targets evidence (0-1)
GALNT12 polypeptide N-acetylgalactosaminyltransferase 12PROTACantibodysmall molecule🧊 AlphaFold structure ↗ 0.69
BRCA1 BRCA1 DNA repair associatedPROTACantibodysmall molecule🧊 AlphaFold structure ↗ 0.12
ATM ATM serine/threonine kinasePROTACsmall molecule🧊 AlphaFold structure ↗ 0.12
ALB albuminPROTACantibodysmall molecule🧊 AlphaFold structure ↗ 0.03
C1GALT1C1 C1GALT1 specific chaperone 1PROTACantibody🧊 AlphaFold structure ↗ 0.01
GALNT3 polypeptide N-acetylgalactosaminyltransferase 3PROTACantibody🧊 AlphaFold structure ↗ 0.01
IFNG interferon gammaPROTACantibodysmall molecule🧊 AlphaFold structure ↗ 0.00
C1GALT1 core 1 synthase, glycoprotein-N-acetylgalactosamine 3-beta-galactosyl…PROTACantibody🧊 AlphaFold structure ↗ 0.00
CLEC6A C-type lectin domain containing 6APROTACantibody🧊 AlphaFold structure ↗ 0.00
PTPRJ protein tyrosine phosphatase receptor type JPROTACantibody🧊 AlphaFold structure ↗ 0.00
APC APC regulator of Wnt signaling pathwayPROTACantibodysmall molecule🧊 AlphaFold structure ↗ 0.00

Green labels: what the target is known to be druggable by. The score combines genetics, somatic mutations, drugs, expression and literature.

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Drugs and candidates

Every medicine linked to colorectal cancer, susceptibility to, 1, by how far it has got

No drugs recorded yet.

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