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๐Ÿ“ฐ Latest breakthroughs
๐Ÿ—บ๏ธ Disease Atlas ยท Genetic, familial or congenital disease

breast-ovarian cancer, familial, susceptibility to, 2

Any hereditary breast ovarian cancer syndrome in which the cause of the disease is a mutation in the BRCA2 gene.

๐Ÿ”” Follow weekly
๐Ÿงฌ23genes / proteins with evidence
๐Ÿ’Š0drugs and clinical candidates
๐Ÿงช1recruiting trials worldwide
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Understand breast-ovarian cancer, familial, susceptibility to, 2

Cancer ยท Cells that grow out of control
๐ŸŽ“ Learn more

What it is

Any hereditary breast ovarian cancer syndrome in which the cause of the disease is a mutation in the BRCA2 gene.

From the Open Targets disease record โ†—

๐Ÿงฌ Cancer: Cancer is a group of diseases in which some of the body's cells grow and divide without control, and can spread to other parts of the body.

โ“ Why it happens

  • Changes (mutations) build up in the genes that tell a cell when to grow, divide and die.
  • Most of these changes happen during life: tobacco, too much sun, alcohol, some infections (such as HPV and hepatitis B and C), radiation, obesity and ageing all raise the risk.
  • Some people inherit a faulty gene that raises their risk, such as BRCA1 or BRCA2.

๐Ÿซ€ What it does to the body

  • Cancer cells form a lump (tumour) that can press on or invade nearby organs.
  • They can travel through the blood or lymph to start new tumours elsewhere (metastasis).
  • Blood cancers crowd out healthy blood cells in the bone marrow.

๐Ÿงฑ Why it is hard to cure

  • Every cancer is different, even between two people with the same type - and inside one tumour.
  • Cancer cells keep changing, so they can learn to resist a medicine that worked at first.
  • Cancer cells are the body's own cells, so killing them without harming healthy cells is hard.
  • Many cancers cause no symptoms until they have spread, and a new medicine often takes more than ten years to go from the lab to patients.

๐Ÿš€ What research is trying now

  • Targeted medicines against the exact gene change in a tumour (for example EGFR, ALK or KRAS).
  • Immunotherapy that helps the immune system recognise cancer, including CAR-T cell therapy.
  • Personalised cancer vaccines built from each tumour's mutations, now in late trials.
  • Blood tests that look for tumour DNA to find cancer earlier, and AI to read scans and slides.

General information about cancer, reviewed by people; it does not describe any one person. Below: the evidence for breast-ovarian cancer, familial, susceptibility to, 2 itself.

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AI briefing

Where the science on breast-ovarian cancer, familial, susceptibility to, 2 stands, from the evidence on this page

AI reads the targets, drugs, trials and papers below and writes where the science stands โ€” every claim cited. It is shared with everyone who opens breast-ovarian cancer, familial, susceptibility to, 2.

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Top targets

Genes and proteins ranked by Open Targets evidence (0-1)
BRCA2 BRCA2 DNA repair associatedPROTACsmall molecule๐ŸงŠ AlphaFold structure โ†— 0.80
BRCA1 BRCA1 DNA repair associatedPROTACantibodysmall molecule๐ŸงŠ AlphaFold structure โ†— 0.43
ZAR1L zygote arrest 1 like๐ŸงŠ AlphaFold structure โ†— 0.34
GPSM2 G protein signaling modulator 2PROTACantibody๐ŸงŠ AlphaFold structure โ†— 0.34
PMS2 PMS1 homolog 2, mismatch repair system componentPROTACsmall molecule๐ŸงŠ AlphaFold structure โ†— 0.34
AKNAD1 AKNA domain containing 1๐ŸงŠ AlphaFold structure โ†— 0.34
CLCC1 chloride channel CLIC like 1PROTACantibody๐ŸงŠ AlphaFold structure โ†— 0.34
TMEM132E transmembrane protein 132EPROTACantibody๐ŸงŠ AlphaFold structure โ†— 0.34
CHEK2 checkpoint kinase 2PROTACsmall molecule๐ŸงŠ AlphaFold structure โ†— 0.27
RAD51C RAD51 paralog CPROTACsmall molecule๐ŸงŠ AlphaFold structure โ†— 0.27
TP53 tumor protein p53PROTACothersmall molecule๐ŸงŠ AlphaFold structure โ†— 0.27
BRIP1 BRCA1 interacting DNA helicase 1PROTAC๐ŸงŠ AlphaFold structure โ†— 0.27
CDH1 cadherin 1PROTACantibodysmall molecule๐ŸงŠ AlphaFold structure โ†— 0.27
STK11 serine/threonine kinase 11PROTACsmall molecule๐ŸงŠ AlphaFold structure โ†— 0.27
RAD50 RAD50 double strand break repair proteinPROTAC๐ŸงŠ AlphaFold structure โ†— 0.12

Green labels: what the target is known to be druggable by. The score combines genetics, somatic mutations, drugs, expression and literature.

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Drugs and candidates

Every medicine linked to breast-ovarian cancer, familial, susceptibility to, 2, by how far it has got

No drugs recorded yet.

๐Ÿ›ก๏ธ

AI Cure shows public evidence (Open Targets, ClinicalTrials.gov, PubMed, openFDA, DepMap, AlphaFold) with its source, and AI summaries that cite it โ€” not medical advice and not a cure. Treatment decisions belong with your doctor. Research ideas are shared only with approved researchers and labs, who can test them. In an emergency call your local emergency number (112 in India and Europe, 911 in the US). AI Cure Terms of Use ยท Privacy