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๐Ÿ“ฐ Latest breakthroughs
๐Ÿ—บ๏ธ Disease Atlas ยท Genetic, familial or congenital disease

Alzheimer disease 18

Any Alzheimer disease in which the cause of the disease is a mutation in the ADAM10 gene.

๐Ÿ”” Follow weekly
๐Ÿงฌ25genes / proteins with evidence
๐Ÿ’Š0drugs and clinical candidates
๐Ÿงช3recruiting trials worldwide
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Understand Alzheimer disease 18

Brain and nerves ยท Nerve cells that slowly stop working
๐ŸŽ“ Learn more

What it is

Any Alzheimer disease in which the cause of the disease is a mutation in the ADAM10 gene.

From the Open Targets disease record โ†—

๐Ÿง  Brain and nerves: In neurodegenerative diseases, nerve cells in the brain or spinal cord stop working and die over time - affecting memory (Alzheimer's disease), movement (Parkinson's disease) or muscles (ALS).

โ“ Why it happens

  • Proteins fold the wrong way and clump together inside or between nerve cells - amyloid and tau in Alzheimer's disease, alpha-synuclein in Parkinson's disease.
  • Inflammation, some genes (such as APOE4) and, above all, age raise the risk.

๐Ÿซ€ What it does to the body

  • As connections between nerve cells are lost, memory, thinking, movement or speech fade.
  • The changes start years - often decades - before the first symptoms.

๐Ÿงฑ Why it is hard to cure

  • Most medicines cannot easily pass the blood-brain barrier that protects the brain.
  • By the time symptoms appear, many nerve cells are already lost, and they do not grow back.
  • Many drug trials have failed, partly because the diseases are found late.

๐Ÿš€ What research is trying now

  • Antibodies that clear amyloid and modestly slow early Alzheimer's disease (approved in some countries).
  • Blood tests that detect Alzheimer's changes years earlier.
  • Gene-targeted medicines, such as one approved in the US for an inherited form of ALS.

General information about brain and nerves, reviewed by people; it does not describe any one person. Below: the evidence for Alzheimer disease 18 itself.

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AI briefing

Where the science on Alzheimer disease 18 stands, from the evidence on this page

AI reads the targets, drugs, trials and papers below and writes where the science stands โ€” every claim cited. It is shared with everyone who opens Alzheimer disease 18.

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Top targets

Genes and proteins ranked by Open Targets evidence (0-1)
ADAM10 ADAM metallopeptidase domain 10PROTACantibodysmall molecule๐ŸงŠ AlphaFold structure โ†— 0.62
APOE apolipoprotein EPROTACantibodysmall molecule๐ŸงŠ AlphaFold structure โ†— 0.02
IL17A interleukin 17APROTACantibodyothersmall molecule๐ŸงŠ AlphaFold structure โ†— 0.01
PPARG peroxisome proliferator activated receptor gammaPROTACsmall molecule๐ŸงŠ AlphaFold structure โ†— 0.01
MAPT microtubule associated protein tauPROTACantibodysmall molecule๐ŸงŠ AlphaFold structure โ†— 0.01
IFNG interferon gammaPROTACantibodysmall molecule๐ŸงŠ AlphaFold structure โ†— 0.00
NCK2 NCK adaptor protein 2PROTACsmall molecule๐ŸงŠ AlphaFold structure โ†— 0.00
FOXP3 forkhead box P3PROTAC๐ŸงŠ AlphaFold structure โ†— 0.00
INS insulinantibodysmall molecule๐ŸงŠ AlphaFold structure โ†— 0.00
VGF VGF nerve growth factor induciblePROTACantibody๐ŸงŠ AlphaFold structure โ†— 0.00
TREM2 triggering receptor expressed on myeloid cells 2antibodysmall molecule๐ŸงŠ AlphaFold structure โ†— 0.00
IL5 interleukin 5PROTACantibody๐ŸงŠ AlphaFold structure โ†— 0.00
NMNAT1 nicotinamide nucleotide adenylyltransferase 1PROTACsmall molecule๐ŸงŠ AlphaFold structure โ†— 0.00
IL13 interleukin 13antibodysmall molecule๐ŸงŠ AlphaFold structure โ†— 0.00
TYROBP transmembrane immune signaling adaptor TYROBPPROTACantibodysmall molecule๐ŸงŠ AlphaFold structure โ†— 0.00

Green labels: what the target is known to be druggable by. The score combines genetics, somatic mutations, drugs, expression and literature.

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Drugs and candidates

Every medicine linked to Alzheimer disease 18, by how far it has got

No drugs recorded yet.

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AI Cure shows public evidence (Open Targets, ClinicalTrials.gov, PubMed, openFDA, DepMap, AlphaFold) with its source, and AI summaries that cite it โ€” not medical advice and not a cure. Treatment decisions belong with your doctor. Research ideas are shared only with approved researchers and labs, who can test them. In an emergency call your local emergency number (112 in India and Europe, 911 in the US). AI Cure Terms of Use ยท Privacy