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๐Ÿ“ฐ Latest breakthroughs
๐Ÿ—บ๏ธ Disease Atlas ยท Genetic, familial or congenital disease

familial pancreatic carcinoma

Familial pancreatic carcinoma is defined by the presence of pancreatic cancer (PC) in two or more first-degree relatives.

๐Ÿ”” Follow weekly
๐Ÿงฌ8803genes / proteins with evidence
๐Ÿ’Š0drugs and clinical candidates
๐Ÿงช12+recruiting trials worldwide
๐Ÿงฌ

Understand familial pancreatic carcinoma

Cancer ยท Cells that grow out of control
๐ŸŽ“ Learn more

What it is

Smoking

Long-term diabetes

Chronic pancreatitis

From MedlinePlus: Pancreatic Cancer (US National Library of Medicine) โ†—

๐Ÿงฌ Cancer: Cancer is a group of diseases in which some of the body's cells grow and divide without control, and can spread to other parts of the body.

โ“ Why it happens

  • Changes (mutations) build up in the genes that tell a cell when to grow, divide and die.
  • Most of these changes happen during life: tobacco, too much sun, alcohol, some infections (such as HPV and hepatitis B and C), radiation, obesity and ageing all raise the risk.
  • Some people inherit a faulty gene that raises their risk, such as BRCA1 or BRCA2.

๐Ÿซ€ What it does to the body

  • Cancer cells form a lump (tumour) that can press on or invade nearby organs.
  • They can travel through the blood or lymph to start new tumours elsewhere (metastasis).
  • Blood cancers crowd out healthy blood cells in the bone marrow.

๐Ÿงฑ Why it is hard to cure

  • Every cancer is different, even between two people with the same type - and inside one tumour.
  • Cancer cells keep changing, so they can learn to resist a medicine that worked at first.
  • Cancer cells are the body's own cells, so killing them without harming healthy cells is hard.
  • Many cancers cause no symptoms until they have spread, and a new medicine often takes more than ten years to go from the lab to patients.

๐Ÿš€ What research is trying now

  • Targeted medicines against the exact gene change in a tumour (for example EGFR, ALK or KRAS).
  • Immunotherapy that helps the immune system recognise cancer, including CAR-T cell therapy.
  • Personalised cancer vaccines built from each tumour's mutations, now in late trials.
  • Blood tests that look for tumour DNA to find cancer earlier, and AI to read scans and slides.

General information about cancer, reviewed by people; it does not describe any one person. Below: the evidence for familial pancreatic carcinoma itself.

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AI briefing

Where the science on familial pancreatic carcinoma stands, from the evidence on this page

AI reads the targets, drugs, trials and papers below and writes where the science stands โ€” every claim cited. It is shared with everyone who opens familial pancreatic carcinoma.

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Top targets

Genes and proteins ranked by Open Targets evidence (0-1)
STK11 serine/threonine kinase 11PROTACsmall molecule๐ŸงŠ AlphaFold structure โ†— 0.72
PALB2 partner and localizer of BRCA2PROTACsmall molecule๐ŸงŠ AlphaFold structure โ†— 0.72
TP53 tumor protein p53PROTACothersmall molecule๐ŸงŠ AlphaFold structure โ†— 0.70
BRCA2 BRCA2 DNA repair associatedPROTACsmall molecule๐ŸงŠ AlphaFold structure โ†— 0.68
KRAS KRas proto-oncogene, GTPasePROTACantibodysmall molecule๐ŸงŠ AlphaFold structure โ†— 0.67
SMAD4 SMAD family member 4PROTACsmall molecule๐ŸงŠ AlphaFold structure โ†— 0.65
BRCA1 BRCA1 DNA repair associatedPROTACantibodysmall molecule๐ŸงŠ AlphaFold structure โ†— 0.63
ATM ATM serine/threonine kinasePROTACsmall molecule๐ŸงŠ AlphaFold structure โ†— 0.60
CHEK2 checkpoint kinase 2PROTACsmall molecule๐ŸงŠ AlphaFold structure โ†— 0.48
C11orf65 chromosome 11 open reading frame 65๐ŸงŠ AlphaFold structure โ†— 0.47
ACVR1B activin A receptor type 1BPROTACantibodysmall molecule๐ŸงŠ AlphaFold structure โ†— 0.45
BRIP1 BRCA1 interacting DNA helicase 1PROTAC๐ŸงŠ AlphaFold structure โ†— 0.42
ETFRF1 electron transfer flavoprotein regulatory factor 1PROTAC๐ŸงŠ AlphaFold structure โ†— 0.39
RABL3 RAB, member of RAS oncogene family like 3PROTAC๐ŸงŠ AlphaFold structure โ†— 0.38
CDKN2A cyclin dependent kinase inhibitor 2A๐ŸงŠ AlphaFold structure โ†— 0.38

Green labels: what the target is known to be druggable by. The score combines genetics, somatic mutations, drugs, expression and literature.

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Drugs and candidates

Every medicine linked to familial pancreatic carcinoma, by how far it has got

No drugs recorded yet.

๐Ÿงช

Recruiting trials

Worldwide, open to new patients now
Telehealth Self-Management Coaching Sessions to Improve Quality of Life in Pancreatic Cancer Survivors and Thโ€ฆNCT06524973 ยท NA ยท ๐Ÿ“ ArcadiaIncreasing Germline Genetic Testing for Patients With CancerNCT07307664 ยท NA ยท ๐Ÿ“ Los AngelesIntegrated Cancer Repository for Cancer ResearchNCT02012699 ยท n/a ยท ๐Ÿ“ Greenwood VillageFamilial Investigations of Childhood Cancer PredispositionNCT03050268 ยท n/a ยท ๐Ÿ“ MemphisA Liquid Biopsy for Pancreatic Cancer Early-detection and Disease MonitoringNCT07700992 ยท n/a ยท ๐Ÿ“ MilanArtificial Intelligence-based Early Screening of Pancreatic Cancer and High Risk Tracing (ESPRIT-AI)NCT04743479 ยท n/a ยท ๐Ÿ“ ShanghaiThe Cancer of the Pancreas Screening-5 CAPS5)StudyNCT02000089 ยท Phase 3 ยท ๐Ÿ“ New HavenStudy Assessing PET Imaging With Zirconium-labelled Girentuximab in Patients With HCC, BTC or NENNCT06735560 ยท NA ยท ๐Ÿ“ NantesGenetic Bases of Neuroendocrine Neoplasms in Mexican PatientsNCT06523582 ยท n/a ยท ๐Ÿ“ Mexico CityPancreatic Cancer GeneticsNCT01102569 ยท n/a ยท ๐Ÿ“ New YorkRegistry of Subjects at Risk of Pancreatic CancerNCT04095195 ยท n/a ยท ๐Ÿ“ RozzanoReach and Engagement of GENetic Education, Risk Assessment, and TEsting Feasibility TrialNCT07787156 ยท NA ยท ๐Ÿ“ Boston Search more trials โ†’
๐Ÿ›ก๏ธ

AI Cure shows public evidence (Open Targets, ClinicalTrials.gov, PubMed, openFDA, DepMap, AlphaFold) with its source, and AI summaries that cite it โ€” not medical advice and not a cure. Treatment decisions belong with your doctor. Research ideas are shared only with approved researchers and labs, who can test them. In an emergency call your local emergency number (112 in India and Europe, 911 in the US). AI Cure Terms of Use ยท Privacy