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🗺️ Disease Atlas · Genetic, familial or congenital disease

hereditary breast carcinoma

Breast carcinoma that has developed in relatives of patients with history of breast carcinoma.

🔔 Follow weekly
🧬9594genes / proteins with evidence
💊0drugs and clinical candidates
🧪12+recruiting trials worldwide
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Understand hereditary breast carcinoma

Cancer · Cells that grow out of control
🎓 Learn more

What it is

Breast cancer is a cancer that starts in breast tissue. It happens when cells in the breast change and grow out of control. New cells grow even when you don't need them, and old cells don't die when they should. These extra cells can form a mass called a tumor.

Sometimes the cancer does not spread any further. This is called "in situ." If the cancer spreads outside the breast, the cancer is called "invasive." It may just spread to nearby tissues and lymph nodes. Or the cancer may metastasize (spread to other parts of the body) through the lymph system or the blood.

Breast cancer is the second most common type of cancer in women in the United States. Rarely, it can also affect men.

From MedlinePlus: Breast Cancer (US National Library of Medicine) ↗

🧬 Cancer: Cancer is a group of diseases in which some of the body's cells grow and divide without control, and can spread to other parts of the body.

❓ Why it happens

  • Changes (mutations) build up in the genes that tell a cell when to grow, divide and die.
  • Most of these changes happen during life: tobacco, too much sun, alcohol, some infections (such as HPV and hepatitis B and C), radiation, obesity and ageing all raise the risk.
  • Some people inherit a faulty gene that raises their risk, such as BRCA1 or BRCA2.

🫀 What it does to the body

  • Cancer cells form a lump (tumour) that can press on or invade nearby organs.
  • They can travel through the blood or lymph to start new tumours elsewhere (metastasis).
  • Blood cancers crowd out healthy blood cells in the bone marrow.

🧱 Why it is hard to cure

  • Every cancer is different, even between two people with the same type - and inside one tumour.
  • Cancer cells keep changing, so they can learn to resist a medicine that worked at first.
  • Cancer cells are the body's own cells, so killing them without harming healthy cells is hard.
  • Many cancers cause no symptoms until they have spread, and a new medicine often takes more than ten years to go from the lab to patients.

🚀 What research is trying now

  • Targeted medicines against the exact gene change in a tumour (for example EGFR, ALK or KRAS).
  • Immunotherapy that helps the immune system recognise cancer, including CAR-T cell therapy.
  • Personalised cancer vaccines built from each tumour's mutations, now in late trials.
  • Blood tests that look for tumour DNA to find cancer earlier, and AI to read scans and slides.

General information about cancer, reviewed by people; it does not describe any one person. Below: the evidence for hereditary breast carcinoma itself.

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AI briefing

Where the science on hereditary breast carcinoma stands, from the evidence on this page

AI reads the targets, drugs, trials and papers below and writes where the science stands — every claim cited. It is shared with everyone who opens hereditary breast carcinoma.

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Top targets

Genes and proteins ranked by Open Targets evidence (0-1)
BRCA1 BRCA1 DNA repair associatedPROTACantibodysmall molecule🧊 AlphaFold structure ↗ 0.87
BRCA2 BRCA2 DNA repair associatedPROTACsmall molecule🧊 AlphaFold structure ↗ 0.85
RAD51C RAD51 paralog CPROTACsmall molecule🧊 AlphaFold structure ↗ 0.81
RAD51D RAD51 paralog DPROTACsmall molecule🧊 AlphaFold structure ↗ 0.77
PALB2 partner and localizer of BRCA2PROTACsmall molecule🧊 AlphaFold structure ↗ 0.76
TP53 tumor protein p53PROTACothersmall molecule🧊 AlphaFold structure ↗ 0.76
ATM ATM serine/threonine kinasePROTACsmall molecule🧊 AlphaFold structure ↗ 0.75
CHEK2 checkpoint kinase 2PROTACsmall molecule🧊 AlphaFold structure ↗ 0.74
BRIP1 BRCA1 interacting DNA helicase 1PROTAC🧊 AlphaFold structure ↗ 0.70
BARD1 BRCA1 associated RING domain 1PROTACsmall molecule🧊 AlphaFold structure ↗ 0.70
RND2 Rho family GTPase 2antibody🧊 AlphaFold structure ↗ 0.67
CDH1 cadherin 1PROTACantibodysmall molecule🧊 AlphaFold structure ↗ 0.62
PTEN phosphatase and tensin homologPROTACantibodysmall molecule🧊 AlphaFold structure ↗ 0.62
KRAS KRas proto-oncogene, GTPasePROTACantibodysmall molecule🧊 AlphaFold structure ↗ 0.61
C11orf65 chromosome 11 open reading frame 65🧊 AlphaFold structure ↗ 0.59

Green labels: what the target is known to be druggable by. The score combines genetics, somatic mutations, drugs, expression and literature.

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Drugs and candidates

Every medicine linked to hereditary breast carcinoma, by how far it has got

No drugs recorded yet.

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AI Cure shows public evidence (Open Targets, ClinicalTrials.gov, PubMed, openFDA, DepMap, AlphaFold) with its source, and AI summaries that cite it — not medical advice and not a cure. Treatment decisions belong with your doctor. Research ideas are shared only with approved researchers and labs, who can test them. In an emergency call your local emergency number (112 in India and Europe, 911 in the US). AI Cure Terms of Use · Privacy