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๐Ÿ“ฐ Latest breakthroughs
๐Ÿ—บ๏ธ Disease Atlas ยท Genetic, familial or congenital disease

familial colorectal cancer

Familial colon cancer is a cluster of colon cancer within a family. Most cases of colon cancer occur sporadically in people with little to no family history of the condition. Approximately 3-5% of colon cancer is considered 'hereditary' and is thought to be caused by an inherited predisposition tocolon cancer that is passed down through a family in an autosomal dominant or autosomal recessive manner. In some of thesโ€ฆ

๐Ÿ”” Follow weekly
๐Ÿงฌ897genes / proteins with evidence
๐Ÿ’Š0drugs and clinical candidates
๐Ÿงช12+recruiting trials worldwide
๐Ÿงฌ

Understand familial colorectal cancer

Cancer ยท Cells that grow out of control
๐ŸŽ“ Learn more

What it is

Colorectal cancer is cancer that develops in the tissues of the colon or rectum. Your colon and rectum are part of your digestive system:

Your colon is the first and longest part of your large intestine. It absorbs water and some nutrients from foods. It also changes the leftover waste products into stool (poop).

Your rectum is the lower part of your large intestine. It's where your body stores stool.

From MedlinePlus: Colorectal Cancer (US National Library of Medicine) โ†—

๐Ÿงฌ Cancer: Cancer is a group of diseases in which some of the body's cells grow and divide without control, and can spread to other parts of the body.

โ“ Why it happens

  • Changes (mutations) build up in the genes that tell a cell when to grow, divide and die.
  • Most of these changes happen during life: tobacco, too much sun, alcohol, some infections (such as HPV and hepatitis B and C), radiation, obesity and ageing all raise the risk.
  • Some people inherit a faulty gene that raises their risk, such as BRCA1 or BRCA2.

๐Ÿซ€ What it does to the body

  • Cancer cells form a lump (tumour) that can press on or invade nearby organs.
  • They can travel through the blood or lymph to start new tumours elsewhere (metastasis).
  • Blood cancers crowd out healthy blood cells in the bone marrow.

๐Ÿงฑ Why it is hard to cure

  • Every cancer is different, even between two people with the same type - and inside one tumour.
  • Cancer cells keep changing, so they can learn to resist a medicine that worked at first.
  • Cancer cells are the body's own cells, so killing them without harming healthy cells is hard.
  • Many cancers cause no symptoms until they have spread, and a new medicine often takes more than ten years to go from the lab to patients.

๐Ÿš€ What research is trying now

  • Targeted medicines against the exact gene change in a tumour (for example EGFR, ALK or KRAS).
  • Immunotherapy that helps the immune system recognise cancer, including CAR-T cell therapy.
  • Personalised cancer vaccines built from each tumour's mutations, now in late trials.
  • Blood tests that look for tumour DNA to find cancer earlier, and AI to read scans and slides.

General information about cancer, reviewed by people; it does not describe any one person. Below: the evidence for familial colorectal cancer itself.

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AI briefing

Where the science on familial colorectal cancer stands, from the evidence on this page

AI reads the targets, drugs, trials and papers below and writes where the science stands โ€” every claim cited. It is shared with everyone who opens familial colorectal cancer.

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Top targets

Genes and proteins ranked by Open Targets evidence (0-1)
MSH2 mutS homolog 2PROTACsmall molecule๐ŸงŠ AlphaFold structure โ†— 0.90
MSH6 mutS homolog 6PROTACsmall molecule๐ŸงŠ AlphaFold structure โ†— 0.88
MLH1 mutL homolog 1PROTACsmall molecule๐ŸงŠ AlphaFold structure โ†— 0.87
PMS2 PMS1 homolog 2, mismatch repair system componentPROTACsmall molecule๐ŸงŠ AlphaFold structure โ†— 0.87
EPCAM epithelial cell adhesion moleculePROTACantibodyothersmall molecule๐ŸงŠ AlphaFold structure โ†— 0.78
FBXO11 F-box protein 11PROTAC๐ŸงŠ AlphaFold structure โ†— 0.73
LRRFIP2 LRR binding FLII interacting protein 2PROTACantibody๐ŸงŠ AlphaFold structure โ†— 0.72
ATM ATM serine/threonine kinasePROTACsmall molecule๐ŸงŠ AlphaFold structure โ†— 0.65
CHEK2 checkpoint kinase 2PROTACsmall molecule๐ŸงŠ AlphaFold structure โ†— 0.63
MUTYH mutY DNA glycosylasePROTACsmall molecule๐ŸงŠ AlphaFold structure โ†— 0.61
POLE DNA polymerase epsilon, catalytic subunitPROTACantibodysmall molecule๐ŸงŠ AlphaFold structure โ†— 0.60
MLH3 mutL homolog 3PROTAC๐ŸงŠ AlphaFold structure โ†— 0.57
TGFBR2 transforming growth factor beta receptor 2PROTACantibodysmall molecule๐ŸงŠ AlphaFold structure โ†— 0.56
BRCA2 BRCA2 DNA repair associatedPROTACsmall molecule๐ŸงŠ AlphaFold structure โ†— 0.56
C11orf65 chromosome 11 open reading frame 65๐ŸงŠ AlphaFold structure โ†— 0.53

Green labels: what the target is known to be druggable by. The score combines genetics, somatic mutations, drugs, expression and literature.

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Drugs and candidates

Every medicine linked to familial colorectal cancer, by how far it has got

No drugs recorded yet.

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Recruiting trials

Worldwide, open to new patients now
Trial of Exercise Therapy in Familial Adenomatous Polyp (FAP)NCT06641310 ยท NA ยท ๐Ÿ“ Ann ArborPhase 3 Trial of eRapa in Patients With Familial Adenomatous PolyposisNCT06950385 ยท Phase 3 ยท ๐Ÿ“ ArcadiaAn Investigational Drug (TPST-1495) in Patients With Familial Adenomatous PolyposisNCT06557733 ยท Phase 2 ยท ๐Ÿ“ PhoenixIncreasing Germline Genetic Testing for Patients With CancerNCT07307664 ยท NA ยท ๐Ÿ“ Los AngelesConnecting Black Families in Houston, Texas to Hereditary Cancer Genetic Counseling, Genetic Testing, and Casโ€ฆNCT05694559 ยท NA ยท ๐Ÿ“ HoustonFamily Communications After Genetic TestingNCT07143487 ยท NA ยท ๐Ÿ“ AnchorageIntegrated Cancer Repository for Cancer ResearchNCT02012699 ยท n/a ยท ๐Ÿ“ Greenwood VillageFamilial Investigations of Childhood Cancer PredispositionNCT03050268 ยท n/a ยท ๐Ÿ“ MemphisFOG-001 in Locally Advanced or Metastatic Solid TumorsNCT05919264 ยท Phase 1, Phase 2 ยท ๐Ÿ“ PhoenixA Personalized Surveillance and Intervention Protocol for Duodenal and Gastric Polyposis in Patients With Famโ€ฆNCT04677998 ยท n/a ยท ๐Ÿ“ HoustonEvaluate REC-4881 in Participants With Familial Adenomatous Polyposis (FAP)NCT05552755 ยท Phase 1, Phase 2 ยท ๐Ÿ“ ScottsdaleA Multi-center Investigation of Family Health.NCT06433349 ยท n/a ยท ๐Ÿ“ Odense C Search more trials โ†’
๐Ÿ›ก๏ธ

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