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🗺️ Disease Atlas · Cardiovascular disorder

coronary artery disorder

Narrowing of the coronary arteries due to fatty deposits inside the arterial walls. The diagnostic criteria may include documented history of any of the following: documented coronary artery stenosis greater than or equal to 50% (by cardiac catheterization or other modality of direct imaging of the coronary arteries); previous coronary artery bypass surgery (CABG); previous percutaneous coronary intervention (PCI); …

🔔 Follow weekly
🧬6771genes / proteins with evidence
💊241drugs and clinical candidates
🧪12+recruiting trials worldwide
✅30approved
📈66phase 3
❤️

Understand coronary artery disorder

Heart and blood vessels · Arteries that narrow and clog
🎓 Learn more

What it is

Coronary artery disease (CAD) is the most common type of heart disease in the United States and a leading cause of death for both men and women.

CAD affects the coronary arteries, which are the blood vessels that carry blood and oxygen to your heart muscle. When these arteries are damaged or diseased, your heart does not get the blood it needs.

What causes coronary artery disease?

From MedlinePlus: Coronary Artery Disease (US National Library of Medicine) ↗

❤️ Heart and blood vessels: Heart and blood vessel (cardiovascular) diseases affect how blood flows. The most common is coronary artery disease, where the arteries that feed the heart become narrow.

❓ Why it happens

  • A fatty plaque slowly builds up inside artery walls (atherosclerosis), over many years.
  • High LDL cholesterol, high blood pressure, smoking, diabetes, obesity, inactivity, family history and age all speed it up.

🫀 What it does to the body

  • Narrow arteries starve the heart muscle of oxygen, causing chest pain.
  • If a plaque breaks, a clot can block the artery completely: a heart attack - or a stroke in the brain.
  • A weakened heart may not pump well enough (heart failure).

🧱 Why it is hard to cure

  • Plaque builds silently for decades; the first sign can be a heart attack.
  • Heart muscle that dies does not grow back.
  • The risk factors are very common and need lifelong control.

🚀 What research is trying now

  • New ways to lower cholesterol, such as PCSK9-blocking medicines and twice-a-year injections.
  • Medicines against lipoprotein(a), an inherited risk factor, in late trials.
  • Gene editing to switch off cholesterol genes for good, in early trials.
  • AI that spots heart risk early from an ECG or a scan.

General information about heart and blood vessels, reviewed by people; it does not describe any one person. Below: the evidence for coronary artery disorder itself.

🤖

AI briefing

Where the science on coronary artery disorder stands, from the evidence on this page

AI reads the targets, drugs, trials and papers below and writes where the science stands — every claim cited. It is shared with everyone who opens coronary artery disorder.

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🎯

Top targets

Genes and proteins ranked by Open Targets evidence (0-1)
APOE apolipoprotein EPROTACantibodysmall molecule🧊 AlphaFold structure ↗ 0.79
LDLR low density lipoprotein receptorPROTACantibodysmall molecule🧊 AlphaFold structure ↗ 0.76
GUCY1A1 guanylate cyclase 1 soluble subunit alpha 1PROTACsmall molecule🧊 AlphaFold structure ↗ 0.74
PCSK9 proprotein convertase subtilisin/kexin type 9PROTACantibodyothersmall molecule🧊 AlphaFold structure ↗ 0.74
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductasePROTACantibodysmall molecule🧊 AlphaFold structure ↗ 0.72
LRP6 LDL receptor related protein 6PROTACantibodysmall molecule🧊 AlphaFold structure ↗ 0.70
GUCY1B1 guanylate cyclase 1 soluble subunit beta 1PROTACsmall molecule🧊 AlphaFold structure ↗ 0.69
GUCY1A2 guanylate cyclase 1 soluble subunit alpha 2PROTACsmall molecule🧊 AlphaFold structure ↗ 0.69
PDE3A phosphodiesterase 3APROTACantibodysmall molecule🧊 AlphaFold structure ↗ 0.68
PDE5A phosphodiesterase 5APROTACsmall molecule🧊 AlphaFold structure ↗ 0.67
APOB apolipoprotein BPROTACantibodysmall molecule🧊 AlphaFold structure ↗ 0.67
CETP cholesteryl ester transfer proteinPROTACantibodysmall molecule🧊 AlphaFold structure ↗ 0.67
LPL lipoprotein lipasePROTACantibodysmall molecule🧊 AlphaFold structure ↗ 0.66
PDE1A phosphodiesterase 1APROTACsmall molecule🧊 AlphaFold structure ↗ 0.63
SORT1 sortilin 1PROTACantibodysmall molecule🧊 AlphaFold structure ↗ 0.62

Green labels: what the target is known to be druggable by. The score combines genetics, somatic mutations, drugs, expression and literature.

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Drugs and candidates

Every medicine linked to coronary artery disorder, by how far it has got
Approved · 20
AlirocumabSubtilisin/kexin type 9 inhibitorApproved
Amlodipine BesylateVoltage-gated L-type calcium channel blockerApproved
Ammonia N 13Approved
Ammonia Solution, StrongApproved
Antithrombin GammaApproved
ArbutamineApproved
Show all 20
AspirinCyclooxygenase inhibitorApproved
Atorvastatin CalciumHMG-CoA reductase inhibitorApproved
Bempedoic AcidATP-citrate synthase inhibitorApproved
ColchicineTubulin inhibitorApproved
DipyridamoleEquilibrative nucleoside transporter 1 inhibitor; 3',5'-cyclic phosphodiesterase inhibitorApproved
EvolocumabSubtilisin/kexin type 9 inhibitorApproved
FendilineApproved
GemfibrozilPeroxisome proliferator-activated receptor alpha agonistApproved
Isosorbide DinitrateSoluble guanylate cyclase activatorApproved
Isosorbide MononitrateSoluble guanylate cyclase activatorApproved
LovastatinHMG-CoA reductase inhibitorApproved
NiacinApproved
NitroglycerinSoluble guanylate cyclase activatorApproved
Perindopril ErbumineAngiotensin-converting enzyme inhibitorApproved
In phase 2 / 3 · 20
AcetaminophenCyclooxygenase inhibitor; Anandamide amidohydrolase inhibitorPhase 3
AliskirenRenin inhibitorPhase 3
AmiodaroneHERG blockerPhase 3
AmlodipineVoltage-gated L-type calcium channel blockerPhase 3
AnacetrapibCholesteryl ester transfer protein inhibitorPhase 3
AnivamersenPhase 3
Show all 20
ApadenosonAdenosine A2a receptor agonistPhase 3
Ascorbic AcidPhase 3
AtorvastatinHMG-CoA reductase inhibitorPhase 3
BivalirudinThrombin inhibitorPhase 3
ChlorthalidoneThiazide-sensitive sodium-chloride cotransporter inhibitorPhase 3
ClarithromycinBacterial 70S ribosome inhibitorPhase 3
ClopidogrelPurinergic receptor P2Y12 antagonistPhase 3
Colestipol HydrochloridePhase 3
DalcetrapibCholesteryl ester transfer protein inhibitorPhase 3
DapagliflozinSodium/glucose cotransporter 2 inhibitorPhase 3
DoxazosinAdrenergic receptor alpha-1 antagonistPhase 3
Ea-230Phase 3
Edetic AcidPhase 3
EnoxaparinPhase 3
Early trials · 20
ArgininePhase 1/2
BerberinePhase 1/2
FluoxetineSerotonin transporter inhibitorPhase 1/2
FlupentixolPhase 1/2
BfpetPhase 1
CatridecacogCoagulation factor XIII exogenous proteinPhase 1
Show all 20
CholesterolPhase 1
Collagenase Clostridium HistolyticumCollagen hydrolytic enzymePhase 1
FanapanelPhase 1
IsofluraneGlycine receptor (alpha-1/beta) positive modulator; GABA-A receptor; anion channel positi…Phase 1
MoxifloxacinTopoisomerase IV inhibitor; Bacterial DNA gyrase inhibitorPhase 1
NurandociguatPhase 1
SevofluraneGlycine receptor (alpha-1/beta) positive modulator; GABA-A receptor; anion channel positi…Phase 1
SirolimusFK506-binding protein 1A inhibitorPhase 1
TirofibanIntegrin alpha-IIb/beta-3 inhibitorPhase 1
VericiguatSoluble guanylate cyclase activatorPhase 1
ZalunfibanIntegrin alpha-IIb/beta-3 inhibitorPhase 1
Citrulline MalateEarly phase 1
NicardipineVoltage-gated L-type calcium channel blockerEarly phase 1
VerapamilVoltage-gated L-type calcium channel blockerEarly phase 1
🧪

Recruiting trials

Worldwide, open to new patients now
Vibrometer Based Pulse Wave Analysis for Arterial Stiffness and Ischemic Heart Disease Risk AssessmentNCT06984211 · n/a · 📍 StockholmCoroflex® ISAR NEO PMCF StudyNCT05698732 · n/a · 📍 Aix-en-ProvenceDOAC in Chinese Patients With Atrial FibrillationNCT05378035 · n/a · 📍 Hong KongEffect of Mazdutide on Coronary Plaque in Patients With Coronary Atherosclerosis and Overweight or ObesityNCT07657676 · Phase 4 · 📍 BeijingEvaluating Atherosclerotic Disease Progression in Patients With Diabetes MellitusNCT07237685 · n/a · 📍 AmsterdamAssociations Between the Microbiome, Skeletal Muscle Perfusion, and Fitness StatusNCT06009276 · n/a · 📍 CharlottesvilleAggressive Lipid Lowering Therapy in ICI-Treated MelanomaNCT07704918 · NA · 📍 AuroraGeometrical Influences on Atherosclerosis and Blood FlowNCT07002697 · n/a · 📍 DhakaMulti-modal Adverse Events Prediction for Premature Coronary Heart Disease Trial: MAP-CHD TrialNCT07004452 · n/a · 📍 BeijingAssessing the Impact of Intensification of Lipid Lowering Therapy With Guidelines-based Evinacumab Administra…NCT07447648 · n/a · 📍 ParisPreliminary Exploration of Factors Affecting Complete Hemostasis and Supine Time After Removal of Femoral Art…NCT07469397 · n/a · 📍 TaipeiInvestigational Trial to Evaluate XC001 Delivered Via an Cardiac Catheter in Subjects With Chronic Angina.NCT07048808 · Phase 2 · 📍 Birmingham Search more trials →
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Newest research

Latest papers on PubMed
Ticagrelor-Induced Bradyarrhythmias in Acute Coronary Syndrome: A Case Series of Three Patients.Cureus 2026 · PMID 42928934Cardiorespiratory Arrest in the Context of Graves' Disease: A Rare Presentation.Cureus 2026 · PMID 42928747Acute myocardial infarction after brief antithrombotic interruption in Kawasaki disease-related coronary aneurysm.Cardiol Young 2026 · PMID 42928466Prior CABG and native-vessel CTO PCI: lesion complexity, strategy planning, procedural burden, and technical success in a multice…BMC Cardiovasc Disord 2026 · PMID 42928096Extreme cardiovascular risk as a major barrier to LDL-C target achievement: insights from ITACARE-P registry.Nutr Metab Cardiovasc Dis 2026 · PMID 42928029Estimated Small Dense LDL Cholesterol and Coronary Artery Disease in Familial Hypercholesterolemia.J Atheroscler Thromb 2026 · PMID 42927934In-Hospital and One-Year Outcomes After Percutaneous Coronary Intervention for Chronic Coronary Occlusion in Octogenarians.Cardiol Ther 2026 · PMID 42927561Clinical Performance and Safety of the Optima Non-compliant Percutaneous Transluminal Coronary Angioplasty Balloon in Contemporar…Cureus 2026 · PMID 42927340 Ask a research question in the Hypothesis Lab →
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