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A progressive degenerative disorder of the central nervous system characterized by loss of dopamine producing neurons in the substantia nigra and the presence of Lewy bodies in the substantia nigra and locus coeruleus. Signs and symptoms include tremor which is most pronounced during rest, muscle rigidity, slowing of the voluntary movements, a tendency to fall back, and a mask-like facial expression.
Symptoms begin gradually, often on one side of the body. Later they affect both sides. They include:
Trembling of hands, arms, legs, jaw and face
Stiffness of the arms, legs and trunk
From MedlinePlus: Parkinson's Disease (US National Library of Medicine) ↗
🧠 Brain and nerves: In neurodegenerative diseases, nerve cells in the brain or spinal cord stop working and die over time - affecting memory (Alzheimer's disease), movement (Parkinson's disease) or muscles (ALS).
General information about brain and nerves, reviewed by people; it does not describe any one person. Below: the evidence for Parkinson disease itself.
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Green labels: what the target is known to be druggable by. The score combines genetics, somatic mutations, drugs, expression and literature.
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