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Trial Match

Clinical trials test new treatments โ€” sometimes the newest options available for a disease. Find trials that are recruiting now, near you. Open one to see its eligibility rules as simple questions to go through with your doctor.

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20 recruiting trials

for Alpha 1-antitrypsin Deficiency (AATD)

Gene Therapy for Alpha 1- Antitrypsin Deficiency NCT06996756Phase 11 site๐Ÿ“ New York Weill Medical College of Cornell University ยท Tests: AAV8hAAT(AVL) Czech AATD Registry NCT05178277n/a1 site๐Ÿ“ Prague Thomayer University Hospital Study to Check the Safety of Fazirsiran and Learn if Fazirsiran Can Help People With Liver Disease and Scarring (Fibrosis) Due to an Abnormal Version of Alpha-1 Antitrypsin Protein NCT05677971Phase 389 sites๐Ÿ“ Birmingham๐Ÿ“ Phoenix๐Ÿ“ Phoenix Takeda ยท Tests: Fazirsiran Injection, Placebo A Study in Adults to Learn About Inherited Alpha-1 Antitrypsin Deficiency (AATD) and AATD Related Liver Problems NCT06512454n/a8 sites๐Ÿ“ Gainesville๐Ÿ“ Charleston๐Ÿ“ Nashville Takeda ยท Tests: No Intervention A Non-inferiority Pharmacokinetic and Safety/Tolerability Study of Two Different Doses of Weekly SC Alpha1-PI 15% Compared With Corresponding Standard IV Alpha1-PI in Participants With Alpha1-Antitrypsin Deficiency (AATD) NCT07555483Phase 322 sites๐Ÿ“ Birmingham๐Ÿ“ Phoenix๐Ÿ“ Scottsdale Grifols Therapeutics LLC ยท Tests: Alpha-1 15%, Liquid Alpha1-PI Alpha-1 Research Registry NCT04157049n/a1 site๐Ÿ“ Coral Gables Alpha-1 Foundation A Phase 1b/2a, Open-label Single Ascending Doses and Multiple Ascending Doses Study in Participants With Pi*ZZ AATD NCT06405633Phase 1, Phase 29 sites๐Ÿ“ Fitzroy๐Ÿ“ Halifax๐Ÿ“ Toronto Wave Life Sciences USA, Inc. ยท Tests: WVE-006 A Study of TSRA-196 in Adults With PiZZ Alpha-1 Antitrypsin Deficiency (AATD) NCT07227207Phase 1, Phase 28 sites๐Ÿ“ Jacksonville๐Ÿ“ Boston๐Ÿ“ Rochester Tessera Therapeutics, Inc. ยท Tests: TSRA-196 Genetic Variation in IgG in Alpha 1 Antitrypsin Deficiency NCT07135427Phase 41 site๐Ÿ“ Birmingham University of Alabama at Birmingham ยท Tests: 20-valent pneumococcal conjugate vaccine Study to Learn About the Safety of Fazirsiran and if it Can Help People With Alpha-1 Antitrypsin Liver Disease With Mild Liver Scarring (Fibrosis) NCT06165341Phase 341 sites๐Ÿ“ Phoenix๐Ÿ“ Phoenix๐Ÿ“ Tucson Takeda ยท Tests: Fazirsiran Injection, Placebo Lung Disease and Its Affect on the Work of White Blood Cells in the Lungs NCT01851642n/a1 site๐Ÿ“ Gainesville University of Florida ยท Tests: History and physical exam., Blood draw., Pulmonary function testing., Albuterol inhaler. A Study of AIR-001 in Adults With Alpha-1 Antitrypsin Deficiency (AATD) NCT07431112Phase 113 sites๐Ÿ“ Melbourne๐Ÿ“ Tbilisi๐Ÿ“ Tbilisi AIRNA Corporation ยท Tests: AIR-001 SAD dose level 1, AIR-001 SAD dose level 2, AIR-001 SAD dose level 3, AIR-001 SAD dose level 4, AIR-001 MD doseโ€ฆ Development of a Prediction Score for the Occurrence of Death or Lung Transplantation in Patients With Emphysema Secondary to Alpha-1-anti-tripsin Deficiency NCT07715617n/a4 sites๐Ÿ“ Bron๐Ÿ“ Lille๐Ÿ“ Paris University Hospital, Bordeaux Screening for Alpha-1 Antitrypsin Deficiency in Patients With Airway Obstruction NCT07152834n/a1 site๐Ÿ“ MuฤŸla MuฤŸla Sฤฑtkฤฑ Koรงman University ยท Tests: Blood Sampling Role of Genetic Factors in the Development of Lung Disease NCT00001532n/a2 sites๐Ÿ“ Bethesda๐Ÿ“ Bethesda National Heart, Lung, and Blood Institute (NHLBI) A Study of KB408 for the Treatment of Alpha-1 Antitrypsin Deficiency NCT06049082Phase 13 sites๐Ÿ“ Gainesville๐Ÿ“ Charleston๐Ÿ“ The Woodlands Krystal Biotech, Inc. ยท Tests: KB408 (Nebulization) The Alpha-1 Foundation's and University of Florida's Alpha-1 Coded Testing (ACT) Study NCT00500123n/a1 site๐Ÿ“ Gainesville University of Florida ยท Tests: Alpha-1 Antitrypsin Genotype A Study to Evaluate the Safety and Efficacy of BEAM-302 in Adult Patients With Alpha-1 Antitrypsin Deficiency (AATD) NCT06389877Phase 1, Phase 212 sites๐Ÿ“ Birmingham๐Ÿ“ Boston๐Ÿ“ Charleston Beam Therapeutics Inc. ยท Tests: BEAM-302 PiMZ Longitudinal Cohort (PiMZ Logic) NCT06505603n/a5 sites๐Ÿ“ Birmingham๐Ÿ“ Los Angeles๐Ÿ“ Denver Columbia University Phase 4, Double-blind Study Evaluating the Response on Computed Tomography (CT) Lung Density Decline Rates of Respreeza / Zemaira Weekly for 3 Years in Adults With alpha1 Antitrypsin Deficiency (AATD) NCT07326592Phase 42 sites๐Ÿ“ Aalborg๐Ÿ“ Vejle CSL Behring ยท Tests: CE1226
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