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Trial Match

Clinical trials test new treatments — sometimes the newest options available for a disease. Find trials that are recruiting now, near you. Open one to see its eligibility rules as simple questions to go through with your doctor.

Know your stage or your test results (such as EGFR, HER2 or BRCA)? Match trials to your own profile - nothing you type is saved.

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30 recruiting trials

for DNA Repair Disorder

Study Evaluating DNA Double-strand Breaks (DSBs) REpair Factors (POLQ, Shieldin Complex and 53BP1) Expression as Biomarker of PARP Inhibitor Resistance in Patients With Deleterious Germline Mutation in BRCA 1/2 and HER2-negative, Metastatic or Locally Advanced Breast Cancer. NCT05378204NA25 sites📍 Bordeaux📍 Caen📍 Clermont-Ferrand Institut Claudius Regaud · Tests: Main study:, Sub-study: Investigation of the Genetics of Hematologic Diseases NCT02720679n/a1 site📍 Memphis St. Jude Children's Research Hospital Role of Acetaldehyde in the Development of Oral Cancer NCT05973656NA1 site📍 Minneapolis Masonic Cancer Center, University of Minnesota · Tests: Alcohol, Biospecimen Collection, Breath Test The Experience of Screening for SCID NCT05651113n/a1 site📍 London King's College London · Tests: SCID Screening Low Dose Treosulfan Based Conditioning Regimen and PTCy in HSCT for Nijmegen Breakage Syndrome NCT06198842Phase 21 site📍 Moscow Federal Research Institute of Pediatric Hematology, Oncolog… · Tests: Treosulfan Safety and Efficacy of Mutation-targeted Precision Genetic Therapy for Ataxia-Telangiectasia (A-T) NCT07215416Phase 1, Phase 21 site📍 Boston Timothy Yu · Tests: Antisense oligonucleotide targeting the ATM gene Menstrual Cup for Early Endometrial Cancer Detection in Lynch Syndrome NCT07220239NA1 site📍 Boston Jessica D. St. Laurent, MD · Tests: Menstrual cup use Data Collection Study of Patients With Non-Malignant Disorders Undergoing UCBT, BMT or PBSCT With RIC NCT04528355n/a1 site📍 Pittsburgh Paul Szabolcs · Tests: data collection An Phase Ib/II Clinical Trial of TCC1727 Combination Therapy in Advanced Solid Tumors NCT07371663Phase 1, Phase 23 sites📍 Beijing📍 Zhengzhou📍 Hangzhou Beijing Tide Pharmaceutical Co., Ltd · Tests: TCC1727 tablet 90mg, TCC1727 tablet 120mg, TCC1727 tablet 160mg, benmelstobart Injection Non-interventional Study to Assess the Number of People With Untreated/Unknown HBV + HDV and HCV in South-East Austria NCT06834178n/a1 site📍 Graz Vanessa Stadlbauer-Koellner, MD Study of Preoperative Radiation Therapy in Participants With Resectable Recurrent Abdominal Adrenocortical Carcinoma NCT06487481Phase 11 site📍 Bethesda National Cancer Institute (NCI) · Tests: Surgical resection, Preoperative RT First in Human Pilot Study to Assess the Safety and Efficacy of Dendritic Cells Loaded With Frameshift Derived Neopeptides for the Prevention of Cancer in of Lynch Syndrome Carriers NCT07163403Phase 11 site📍 Barcelona Fundacion Clinic per a la Recerca Biomédica · Tests: Autologous Tolerogenic Dendritic cells INSIDE: Identification of Genomic Screening Pathways in Cancer Patients With DNA Repair Alterations NCT06334809n/a2 sites📍 Candiolo📍 Orbassano Fondazione del Piemonte per l'Oncologia Olaparib With or Without Durvalumab for DDR Gene Mutated Biliary Tract Cancer Following Platinum-based Chemotherapy NCT05222971Phase 21 site📍 Seoul Asan Medical Center · Tests: Durvalumab, Olaparib Lynch Syndrome X-Talk of Enteral Mucosa With Immune System NCT06708429n/a5 sites📍 Monrovia📍 Milan📍 Milan San Raffaele University · Tests: LYNX EYE (Lynch syndrome X-Talk of Enteral mucosa with Immune System) Small Bowel Capsule Endoscopy in Lynch Syndrome NCT07472686n/a1 site📍 Paris Assistance Publique - Hôpitaux de Paris ctDNA-Guided Immunotherapy for dMMR/MSI-H Colon Cancer NCT07841236Phase 21 site📍 Shanghai Fudan University · Tests: PD-1 inhibitor, CTLA-4 inhibitor, ctDNA/MRD testing, Curative Surgery Development of IPS from Donated Somatic Cells of Patients with Neurological Diseases NCT00874783n/a1 site📍 Jerusalem Hadassah Medical Organization Natural History Study for DNA Repair Disorders NCT05484570n/a1 site📍 Minneapolis University of Minnesota · Tests: Interval History, Physical Examination, ECAB Assessment, Gait Assessment, Specimen Sample Collection DNA Repair Activity in the Skin of Day and Night Shift Workers NCT04122456NA1 site📍 Fairborn Wright State University · Tests: Ultraviolet B Radiation, No Ultraviolet B Radiation A Phase IIa Randomized, Double-Blinded Clinical Trial of Naproxen or Aspirin for Cancer Immune Interception in Lynch Syndrome NCT05411718Phase 21 site📍 Houston M.D. Anderson Cancer Center · Tests: Naproxen, Aspirin A Study to Assess the Safety, Tolerability, and Efficacy of NDI-219216 in Patients With Advanced Solid Tumors. NCT06898450Phase 1, Phase 222 sites📍 Los Angeles📍 Chicago📍 Louisville Nimbus Wadjet, Inc. · Tests: NDI-219216 A Study to Evaluate the Efficacy of VVD-133214 in Combination With Pembrolizumab Compared With Pembrolizumab Alone in Participants With Advanced Cancer of the Colon or Rectum NCT07811193Phase 2122 sites📍 Tucson📍 Ann Arbor📍 Detroit Vividion Therapeutics, Inc. · Tests: VVD-133214, Pembrolizumab Willingness to Participate in a Trial Comparing Standard Genetic Counseling Versus Personalized Genetic Counseling NCT05126810n/a1 site📍 Houston M.D. Anderson Cancer Center · Tests: Questionnaire Administration Impact of Transcatheter Aortic Valve Implantation and Mitral Valve Repair on Sleep-Disordered Breathing NCT07520656n/a1 site📍 Athens Aristides Plaitis Integrated Cancer Repository for Cancer Research NCT02012699n/a42 sites📍 Greenwood Village📍 Manchester📍 Daytona Beach University of Nebraska Rare Disease Patient Registry & Natural History Study - Coordination of Rare Diseases at Sanford NCT01793168n/a2 sites📍 Sioux Falls📍 Sydney Sanford Health Familial Investigations of Childhood Cancer Predisposition NCT03050268n/a1 site📍 Memphis St. Jude Children's Research Hospital Afatinib in Patients With Fanconi Anemia (FA) and Advanced Head and Neck Squamous Cell Carcinoma (HNSCC) NCT06648096Phase 1, Phase 22 sites📍 Hanover📍 Barcelona Fundació Institut de Recerca de l'Hospital de la Santa Creu… · Tests: Afatinib CfDNA in Hereditary And High-risk Malignancies 2 NCT06726642n/a8 sites📍 Vancouver📍 St. John's📍 Halifax University Health Network, Toronto · Tests: Cell-free DNA analysis
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