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Trial Match

Clinical trials test new treatments โ€” sometimes the newest options available for a disease. Find trials that are recruiting now, near you. Open one to see its eligibility rules as simple questions to go through with your doctor.

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30 recruiting trials

for Glioblastoma (GBM)

Study in Children and Adolescents of 177Lu-DOTATATE (Lutatheraยฎ) Combined With the PARP Inhibitor Olaparib for the Treatment of Recurrent or Relapsed Solid Tumours Expressing Somatostatin Receptor (SSTR) (LuPARPed). NCT06607692Phase 1, Phase 21 site๐Ÿ“ Boadilla del Monte Fundaciรณn de investigaciรณn HM ยท Tests: Olaparib; 177Lu-DOTATATE Temporally-Modulated Pulsed Radiation Therapy Versus Standard Radiation Therapy for the Treatment of Newly Diagnosed, IDH Wildtype, MGMT-Unmethylated Glioblastoma NCT07452458Phase 354 sites๐Ÿ“ Irvine๐Ÿ“ Los Angeles๐Ÿ“ Orange NRG Oncology ยท Tests: Biospecimen Collection, Computed Tomography, Magnetic Resonance Imaging, Questionnaire Administration, Radiation Therapy Chemoradiotherapy Versus Chemotherapy for Elderly and Frail GBM Patients NCT04765514Phase 22 sites๐Ÿ“ Calgary๐Ÿ“ Edmonton AHS Cancer Control Alberta ยท Tests: Temozolomide monotherapy, Chemo-Radiotherapy with concurrent temozolomide. A Trial of RSC-1255 for Treatment of Patients With Advanced Malignancies NCT04678648Phase 13 sites๐Ÿ“ Los Angeles๐Ÿ“ Denver๐Ÿ“ Nashville RasCal Therapeutics, Inc. ยท Tests: RSC-1255 Dose Escalation, RSC-1255 Dose Expansion Sonodynamic Therapy in Patients With Recurrent GBM NCT06039709Phase 11 site๐Ÿ“ Charlottesville Shayan Moosa, MD ยท Tests: 5-ALA and Low-Intensity Focused Ultrasound (SDT) A Phase 2 and Pharmacodynamic Study of Sitagliptin in Patients With Progressive Grade 4 Gliomas NCT07003542Phase 21 site๐Ÿ“ Cleveland Case Comprehensive Cancer Center ยท Tests: Sitagliptin Predictive Value of Soluble CD146 in Glioblastoma Patients NCT06001281NA1 site๐Ÿ“ Marseille Assistance Publique Hopitaux De Marseille ยท Tests: plasma collection Locoregional Administration of Genetically Engineered Cells (EGFR/IL13Rฮฑ2 Pool-CAR T Cells) for the Treatment of Recurrent or Progressive High-Grade Gliomas NCT07544992Phase 11 site๐Ÿ“ Duarte City of Hope Medical Center ยท Tests: Autologous Anti-EGFR/Anti-IL13Ralpha2 CAR T-cells, Biopsy Procedure, Biospecimen Collection, Echocardiography Test, FDGโ€ฆ Window of Opportunity Study of Lixumistat in Patients With Newly Diagnosed Glioblastoma NCT07884344EARLY Phase 11 site๐Ÿ“ Miami Macarena De La Fuente, MD ยท Tests: Lixumistat - Cohort 1, Lixumistat - Cohort 2 Feasibility of Intra- and Post-operative Microdialysis During Neurosurgery for Central Nervous System Lesions NCT04047264NA1 site๐Ÿ“ Rochester Mayo Clinic ยท Tests: Microdialysis, Magnetic Resonance Imaging, Computed Tomography Daily Temozolomide for Elderly Patients With Unmethylated MGMT- Promoter Newly Diagnosed GliOblatoma NCT07476794Phase 21 site๐Ÿ“ Toronto Sunnybrook Health Sciences Centre ยท Tests: Daily TMZ Intracranial Genetically Modified Immune Cells (TGFฮฒR2KO/IL13Rฮฑ2 CAR T-Cells) for the Treatment of Recurrent or Progressive Glioblastoma or Grade 3 or 4 IDH-Mutant Astrocytoma NCT06815029Phase 11 site๐Ÿ“ Duarte City of Hope Medical Center ยท Tests: Biospecimen Collection, Chimeric Antigen Receptor T-Cell Therapy, Echocardiography, Fludeoxyglucose F-18, Intracranial โ€ฆ Glioma Adaptive Radiotherapy With Development of an Artificial Intelligence Workflow NCT06492486Phase 21 site๐Ÿ“ Mumbai Tata Memorial Centre ยท Tests: Adaptive radiotherapy Repeated Super-selective Intraarterial Cerebral Infusion of Bevacizumab (Avastin) for Treatment of Relapsed GBM and AA NCT01269853Phase 1, Phase 21 site๐Ÿ“ New York Northwell Health ยท Tests: Bevacizumab, Bevacizumab Application of FET-PET in Fusion With MRI in the Treatment of Glioblastoma Multiforme [TYR-GLIO] NCT06466031NA1 site๐Ÿ“ Lodz Copernicus Memorial Hospital ยท Tests: MRI & PET fusion, MRI+T1C Injection of Active Allogeneic Natural Killer Cells in Patients With Gliomas NCT06687681Phase 21 site๐Ÿ“ Tehran Marzieh Ebrahimi ยท Tests: NK cell therapy hSTAR GBM (Hematopoetic Stem Cell (HPC) Rescue for GBM) NCT05052957Phase 21 site๐Ÿ“ Cleveland Leland Metheny ยท Tests: P140K-MGMT, O6-benzylguanine, Photon Based Radiotherapy, temozolomide, Filgrastim Evaluation of the CONVIVO System NCT05139277NA1 site๐Ÿ“ Lebanon Dartmouth-Hitchcock Medical Center ยท Tests: CONVIVO system, Conventional histologic evaluation Evaluating Safety, Tolerability, and Preliminary Efficacy of YSCH-01 Monotherapy and in Combination With Atezolizumab for Recurrent Glioblastoma NCT07538128EARLY Phase 11 site๐Ÿ“ Shanghai Huashan Hospital ยท Tests: YSCH-01, Atezolizumab (1200 mg every three weeks) BRiTE - Bispecific T Cell Engager for Patients With Glioblastoma NCT04903795Phase 11 site๐Ÿ“ Durham Mustafa Khasraw, MBChB, MD, FRCP, FRACP ยท Tests: hEGFRvIII-CD3 (BRiTE) Trial of Glioblastoma Immunotherapy Advancement With Nivolumab and Relatlimab NCT06816927Phase 24 sites๐Ÿ“ New York๐Ÿ“ Durham๐Ÿ“ Houston Duke University ยท Tests: Nivolumab, Relatlimab, TMZ, Radiation Therapy A Feasibility Study to Evaluate the Safety of the TheraSphere Glioblastoma (GBM) Device in Patients With Recurrent GBM NCT05303467Phase 19 sites๐Ÿ“ Birmingham๐Ÿ“ San Diego๐Ÿ“ San Francisco Boston Scientific Corporation ยท Tests: TheraSphere GBM Multiple Intracerebral Doses of Neural Stem Cell-Based Virotherapy (NSC-CRAd-S-pk7) for the Treatment of Recurrent High-Grade Gliomas NCT05139056Phase 14 sites๐Ÿ“ Duarte๐Ÿ“ Stanford๐Ÿ“ Chicago City of Hope Medical Center ยท Tests: Neural Stem Cells-expressing CRAd-S-pk7, Resection Pilot IntraOperative Neuronal Electrophysiology in Tumor rElatEd suRgery NCT06617208NA1 site๐Ÿ“ Rotterdam Erasmus Medical Center ยท Tests: Neuropixel probe recording Proof-of-Concept Study of ACT001 in Adult Patients With Recurrent Glioblastoma Harbouring STAT3-High Signature NCT06894225Phase 21 site๐Ÿ“ Singapore National Neuroscience Institute ยท Tests: ACT001 Mental Health and Suicidality in Glioblastoma Patients in Germany NCT07409584n/a6 sites๐Ÿ“ Berlin๐Ÿ“ Bochum๐Ÿ“ Essen University Hospital, Essen ยท Tests: Medical history, physical examination, completing questionnaires, data collection Ruxolitinib With Radiation and Temozolomide Compared to Radiation and Temozolomide for Newly Diagnosed Glioblastoma NCT06991101Phase 22 sites๐Ÿ“ Miami๐Ÿ“ New York Baptist Health South Florida ยท Tests: Ruxolitinib, Temozolomide, Radiation Therapy Study of Silevertinib With Temozolomide for the Treatment of Newly Diagnosed GBM With Unmethylated MGMT and EGFRvIII NCT07326566Phase 235 sites๐Ÿ“ Birmingham๐Ÿ“ Springdale๐Ÿ“ La Jolla Black Diamond Therapeutics, Inc. ยท Tests: silevertinib in combination with temozolomide, temozolomide (TMZ) Evaluation of Eflornithine Plus Temozolomide in Patients With Newly Diagnosed Glioblastoma or Astrocytoma NCT05879367Phase 18 sites๐Ÿ“ Birmingham๐Ÿ“ Detroit๐Ÿ“ New York Orbus Therapeutics, Inc. ยท Tests: Eflornithine (Dose Level 1), Eflornithine (Dose Level 2), Eflornithine (Dose Level -1), Temozolomide Evaluate the Role of Anthracycline After Radio Therapy in Patients With Glioblastoma (pGBM). NCT06297512Phase 21 site๐Ÿ“ Florence Iacopo Sardi ยท Tests: Radiotherapy, Temozolomide, Doxorubicin
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