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Trial Match

Clinical trials test new treatments โ€” sometimes the newest options available for a disease. Find trials that are recruiting now, near you. Open one to see its eligibility rules as simple questions to go through with your doctor.

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30 recruiting trials

for Intrathecal Drug Delivery

Intrathecal Cytarabine and Hydrocortisone for the Early Treatment of ICANS in Patients Undergoing CAR T Therapy for Non Hodgkin Lymphoma NCT07763210Phase 21 site๐Ÿ“ Nashville Vanderbilt-Ingram Cancer Center ยท Tests: Therapeutic Hydrocortisone, Cytarabine, Dexamethasone, Methylprednisolone, Cyclophosphamide Intrathecal Cytarabine, Methotrexate, and Hydrocortisone for the Prevention of High-Grade Chimeric Antigen Receptor T-Cell-Associated Neurotoxicity Syndrome NCT06895473Phase 21 site๐Ÿ“ Portland OHSU Knight Cancer Institute ยท Tests: Biospecimen Collection, Cytarabine, Lumbar Puncture, Methotrexate, Therapeutic Hydrocortisone Phase 3 Efficacy Study With Concurrent Control of IT MELPIDA in SPG50.Concurrent Controls. NCT06692712Phase 32 sites๐Ÿ“ Dallas๐Ÿ“ Barcelona Elpida Therapeutics SPC ยท Tests: MELPIDA Study of an Intrathecal Port and Catheter System for Subjects With Spinal Muscular Atrophy NCT05866419NA21 sites๐Ÿ“ Phoenix๐Ÿ“ Orange๐Ÿ“ Palo Alto Alcyone Therapeutics, Inc ยท Tests: ThecaFlex DRx System Intrathecal Therapy Versus Standard Care for Severe Cancer Pain NCT07691840NA1 site๐Ÿ“ Jette Universitair Ziekenhuis Brussel ยท Tests: Intrathecal Drug Delivery, Comprehensive Medical Management Safety and Efficacy of Mutation-targeted Precision Genetic Therapy for Ataxia-Telangiectasia (A-T) NCT07215416Phase 1, Phase 21 site๐Ÿ“ Boston Timothy Yu ยท Tests: Antisense oligonucleotide targeting the ATM gene Intrathecal Chemoprophylaxis to Prevent Neurotoxicity Associated With Blinatumomab Therapy for Acute Lymphoblastic Leukemia NCT05519579Phase 21 site๐Ÿ“ Atlanta Northside Hospital, Inc. ยท Tests: Methotrexate, Blinatumomab Safety of Cultured Allogeneic Adult Umbilical-cord or Placental Derived Mesenchymal Stem Cell Intrathecal Injection for SCI NCT05018793Phase 12 sites๐Ÿ“ Naples๐Ÿ“ Athens The Foundation for Orthopaedics and Regenerative Medicine ยท Tests: Cultured Allogeneic Adult Umbilical-cord or Placental Derived Mesenchymal Stem Cell Intrathecal injection Safety and Tolerability Study of ST-503 for Refractory Pain Due to Peripheral Neuropathy (Small Fiber Predominant, SFN) NCT06980948Phase 1, Phase 211 sites๐Ÿ“ Scottsdale๐Ÿ“ Little Rock๐Ÿ“ La Jolla Sangamo Therapeutics ยท Tests: ST-503, Sham (No Treatment) Intrathecal Injection Pemetrexed And Bevacizumab in Patients With Leptomeningeal Metastases in NSCLC NCT06663306Phase 11 site๐Ÿ“ Shanghai Shanghai Chest Hospital ยท Tests: Pemetrexed, Bevacizumab Intrathecal Baclofen and Pediatric Dystonia NCT06606574NA1 site๐Ÿ“ Houston Baylor College of Medicine ยท Tests: Titration protocol Furmonertinib Combined With Intrathecal Chemotherapy and Stereotactic Radiotherapy (SRT) for EGFR-Mutated NSCLC Patients With Brain Parenchymal and Leptomeningeal Metastases NCT07304739Phase 23 sites๐Ÿ“ Cangzhou๐Ÿ“ Tianjin๐Ÿ“ Tianjin Tianjin Medical University Cancer Institute and Hospital ยท Tests: Furmonertinib, Intrathecal chemotherapy, Stereotactic radiotherapy Intra-pemetrexed Plus Third-generation Small Molecule TKI Drugs (e.g. 'Osimertinib') Versus Third-generation Small Molecule TKI Drugs Alone for Leptomeningeal Metastasis From Epidermal Growth Factor Receptor Mutation-Positive Non-Small-cell Lung Cancer NCT06304441NA1 site๐Ÿ“ Huizhou Guangzhou Medical University ยท Tests: Osimertinib, Pemetrexed Comparison Between Epidural Analgesia and Intrathecal Opioid Analgesia for Pain Management in Open Nephrectomy NCT06595329Phase 11 site๐Ÿ“ Split University Hospital of Split ยท Tests: Epidural analgesia, Intrathecal opioid analgesia Sacituzumab Govitecan and Intrathecal Chemotherapy for Treating Leptomeningeal Metastases From Her2-negative Breast Cancer NCT06462092Phase 1, Phase 21 site๐Ÿ“ Huizhou Guangzhou Medical University ยท Tests: Sacituzumab Govitecan, Pemetrexed The Effect of Mandala on Anxiety and Fear Levels in Children With Leukemia Before Intrathecal Chemotherapy Treatment NCT07203742NA1 site๐Ÿ“ Izmir Ege University ยท Tests: mandala painting Tianasen (ASO-GNAO1) for GNAO1-Encephalopathy With Epilepsy and Movement Disorders. NCT07363603Phase 1, Phase 21 site๐Ÿ“ Moscow Pirogov Russian National Research Medical University ยท Tests: Antisense oligonucleotide treatment (ASO) Pilot Study of IT Topotecan and Maintenance Chemotherapy for HR-EBTs in Children < 6 Years, Post Consolidation NCT06942039EARLY Phase 112 sites๐Ÿ“ Calgary๐Ÿ“ Vancouver๐Ÿ“ Winnipeg C17 Council ยท Tests: Cytarabine IT, hydrocortisone, Cisplatin, Vincristine, Etoposide Combined Intrathecal Dexmedetomidine and Adductor Canal Block for Analgesia After Total Knee Arthroplasty NCT06837844NA1 site๐Ÿ“ Kafr ash Shaykh Kafrelsheikh University ยท Tests: Intrathecal Dexmedetomidine, Adductor Canal Block, Intrathecal Dexmedetomidine + Adductor Canal Block UCB Transplant of Inherited Metabolic Diseases With Administration of Intrathecal UCB Derived Oligodendrocyte-Like Cells NCT02254863Phase 11 site๐Ÿ“ Durham Joanne Kurtzberg, MD ยท Tests: DUOC-01 A Study to Evaluate the Tolerability, Safety and Efficacy of VGN-R13 in Patients with ALS NCT06849609EARLY Phase 11 site๐Ÿ“ Wuhan Hong Chen ยท Tests: VGN-R13 A Study of Deferoxamine (DFO) in People With Leptomeningeal Metastasis NCT05184816Phase 17 sites๐Ÿ“ Basking Ridge๐Ÿ“ Middletown๐Ÿ“ Montvale Memorial Sloan Kettering Cancer Center ยท Tests: Deferoxamine (DFO) Melpida: Recombinant Adeno-associated Virus (Serotype 9) Encoding a Codon Optimized Human AP4M1 Transgene (hAP4M1opt) NCT05518188Phase 1, Phase 21 site๐Ÿ“ Dallas Elpida Therapeutics SPC ยท Tests: MELPIDA Intrathecal PD-1/VEGF Bispecific Antibody Plus Pemetrexed for Leptomeningeal Metastasis NCT06809517Phase 1, Phase 21 site๐Ÿ“ Huizhou Guangzhou Medical University ยท Tests: AK112, Pemetrexed (Alimta) Intrathecal Pemetrexed for Leptomeningeal Metastasis in EGFR-Mutant NSCLC NCT05805631Phase 21 site๐Ÿ“ Taipei Taipei Veterans General Hospital, Taiwan ยท Tests: Pemetrexed Intrathecal Morphine Injection Versus Continuous Wound Infiltration After Pancreaticoduodenectomy NCT06761989NA1 site๐Ÿ“ Seoul Seoul National University Hospital ยท Tests: Intrathecal morphine injection, Continuous wound infiltration Comparison of the Postoperative Analgesic Effects of ITM and Bi-level ESPB in Liver Transplantation Donors NCT07123740NA1 site๐Ÿ“ AltฤฑndaฤŸ Ankara Etlik City Hospital ยท Tests: Intrathecal Morphine, Bi-level Erector Spinae Plane Block Therapeutic Effects of R-IDARAM and Intrathecal Immunochemotherapy on Elderly Patients With PCNSL NCT02836158Phase 2, Phase 31 site๐Ÿ“ Beijing Navy General Hospital, Beijing ยท Tests: R-IDARAM plus intrathecal chemotherapy Patient Preference and Long-term Outcomes in Persistent Spinal Pain Syndrome: A Prospective Study Comparing Spinal Cord Stimulation to Intrathecal Drug Delivery. NCT07091123Phase 41 site๐Ÿ“ Cleveland University Hospitals Cleveland Medical Center ยท Tests: Pain pump, Bupivacain 0.625%/Fentanyl 2mcg/ml, Spinal Cord Stimulator (SCS) Safety and Efficacy Evaluation of GC101 Gene Therapy Via Intrathecal (IT) Injectionin the Treatment of Patients With Type 2 Spinal Muscular Atrophy (SMA) - Phase III NCT06971094Phase 37 sites๐Ÿ“ Beijing๐Ÿ“ Beijing๐Ÿ“ Beijing GeneCradle Inc ยท Tests: GC101 adeno-associated virus injection
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