🌐 EnglishEN

AI Cure is a research tool showing open data. Not medical advice. Discuss with your doctor. Terms

🧪

Trial Match

Clinical trials test new treatments — sometimes the newest options available for a disease. Find trials that are recruiting now, near you. Open one to see its eligibility rules as simple questions to go through with your doctor.

Know your stage or your test results (such as EGFR, HER2 or BRCA)? Match trials to your own profile - nothing you type is saved.

🎯 Match trials to me

30 recruiting trials

for Leptomeningeal Disease

Neoadjuvant Stereotactic Radiotherapy for Brain Metastasis NCT06933199NA4 sites📍 Ostrava📍 Brno📍 Hradec Králové University Hospital Ostrava · Tests: Neoadjuvant Stereotactic Radiotherapy (NaSRT), Postoperative Stereotactic Radiotherapy (SRT) Proton Cranio-spinal Irradiation for Leptomeningeal Metastasis NCT05746754NA2 sites📍 Aarhus📍 Aalborg University of Aarhus · Tests: CSI Study in Patients With Breast Cancer Leptomeningeal Metastasis NCT06638294n/a2 sites📍 Washington D.C.📍 Baltimore Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins Optimizing Contrast Dose and Scanning Parameters for Detection of Leptomeningeal Disease NCT07415018NA1 site📍 Houston M.D. Anderson Cancer Center · Tests: MRI Scan, VUEWAY, Gadavist Pulsatile High-dose Furmonertinib in EGFR-mutant NSCLC With Leptomeningeal Metastasis NCT07348965NA1 site📍 Guangzhou Guangzhou University of Traditional Chinese Medicine · Tests: Furmonertinib 320mg qod po, Furmonertinib 160mg qd po Testing Proton Craniospinal Radiation Therapy Versus the Usual Radiation Therapy for Leptomeningeal Metastasis, RADIATE-LM Trial NCT06500481Phase 358 sites📍 Phoenix📍 Little Rock📍 Encinitas NRG Oncology · Tests: Biospecimen Collection, Computed Tomography, Involved-Field Radiation Therapy, Lumbar Puncture, Magnetic Resonance Imag… Efficacy and Resistance Mechanisms of IP in NSCLC With Leptomeningeal Metastases NCT06440954Phase 21 site📍 Changsha Hunan Province Tumor Hospital · Tests: Intrathecal pemetrexed Intrathecal Injection Pemetrexed And Bevacizumab in Patients With Leptomeningeal Metastases in NSCLC NCT06663306Phase 11 site📍 Shanghai Shanghai Chest Hospital · Tests: Pemetrexed, Bevacizumab CSF Analysis in EGFR Mutant Non-Small Cell Lung Cancer With Leptomeningeal Disease NCT05257967NA1 site📍 Vancouver British Columbia Cancer Agency · Tests: Lumbar puncture and Phlebotomy Furmonertinib Combined With Intrathecal Chemotherapy and Stereotactic Radiotherapy (SRT) for EGFR-Mutated NSCLC Patients With Brain Parenchymal and Leptomeningeal Metastases NCT07304739Phase 23 sites📍 Cangzhou📍 Tianjin📍 Tianjin Tianjin Medical University Cancer Institute and Hospital · Tests: Furmonertinib, Intrathecal chemotherapy, Stereotactic radiotherapy Intra-pemetrexed Plus Third-generation Small Molecule TKI Drugs (e.g. 'Osimertinib') Versus Third-generation Small Molecule TKI Drugs Alone for Leptomeningeal Metastasis From Epidermal Growth Factor Receptor Mutation-Positive Non-Small-cell Lung Cancer NCT06304441NA1 site📍 Huizhou Guangzhou Medical University · Tests: Osimertinib, Pemetrexed Zorifertinib With Osimertinib for NSCLC With Meningeal Progression NCT07361705Phase 15 sites📍 Beijing📍 Shengyang📍 Guangzhou Alpha Biopharma (Jiangsu) Co., Ltd. · Tests: Zorifertinib and Osimertinib Combination Therapy Sacituzumab Govitecan and Intrathecal Chemotherapy for Treating Leptomeningeal Metastases From Her2-negative Breast Cancer NCT06462092Phase 1, Phase 21 site📍 Huizhou Guangzhou Medical University · Tests: Sacituzumab Govitecan, Pemetrexed A Study of the Safety and Efficacy of Pemetrexed Combined with Nivolumab Via Intraventricular Injection for the Treatment of Refractory Non-squamous Non-small Cell Lung Cancer with Leptomeningeal Metastases NCT06901817Phase 21 site📍 Shanghai Shanghai Cancer Hospital, China · Tests: Intraventricular Pemetrexed, Intraventricular Nivolumab, Intraventricular Dexamethasone Tumor Treating Fields for the Treatment of Leptomeningeal Metastases of the Spine in Patients With Breast or Lung Cancer NCT05746325NA1 site📍 Jacksonville Mayo Clinic · Tests: Digital Photography, Lumbar Puncture, Magnetic Resonance Imaging, Medical Device Usage and Evaluation, Biospecimen Coll… A Phase IIa Study to Evaluate NBQ72S NCT06810804Phase 21 site📍 Beijing Nantong Bencao Quadriga Medical Technology Co. Ltd. · Tests: NBQ72S Dual-targeting VEGFR1 and PD-L1 CAR-T for Pleural, Peritoneal, or Leptomeningeal Metastases NCT05477927Phase 11 site📍 Chengdu Sichuan University · Tests: Dual-targeting VEGFR1/PD-L1 CAR-T cells A Study of Deferoxamine (DFO) in People With Leptomeningeal Metastasis NCT05184816Phase 17 sites📍 Basking Ridge📍 Middletown📍 Montvale Memorial Sloan Kettering Cancer Center · Tests: Deferoxamine (DFO) SJ901: Evaluation of Mirdametinib in Children, Adolescents, and Young Adults With Low-Grade Glioma NCT04923126Phase 1, Phase 21 site📍 Memphis St. Jude Children's Research Hospital · Tests: Mirdametinib Intrathecal PD-1/VEGF Bispecific Antibody Plus Pemetrexed for Leptomeningeal Metastasis NCT06809517Phase 1, Phase 21 site📍 Huizhou Guangzhou Medical University · Tests: AK112, Pemetrexed (Alimta) Hippocampal Avoidance in Craniospinal Irradiation for the Treatment of Leptomeningeal Metastases From Breast Cancer or Non-small Cell Lung Cancer NCT06518057Phase 23 sites📍 San Francisco📍 New York📍 Seattle University of Washington · Tests: Biospecimen Collection, Computed Tomography, Electronic Health Record Review, Lumbar Puncture, Magnetic Resonance Imagi… Intrathecal Pemetrexed for Leptomeningeal Metastasis in EGFR-Mutant NSCLC NCT05805631Phase 21 site📍 Taipei Taipei Veterans General Hospital, Taiwan · Tests: Pemetrexed Photon Craniospinal Irradiation for the Treatment of Leptomeningeal Disease Secondary to Breast Cancer or Non-small Cell Lung Cancer NCT06910761Phase 22 sites📍 Duarte📍 Irvine City of Hope Medical Center · Tests: Biospecimen Collection, Craniospinal Irradiation, Electronic Health Record Review, Lumbar Puncture, Magnetic Resonance … Prospective Evaluation Of High-Dose Systemic Methotrexate In Patients With Breast Cancer And Leptomeningeal Metastasis NCT02422641Phase 23 sites📍 Baltimore📍 St Louis📍 Winston-Salem Wake Forest University Health Sciences · Tests: High-dose Methotrexate (8 gm/m2; HD-MTX) Non Interventional German Leptomeningeal Disease Register NCT06146010n/a7 sites📍 Bonn📍 Mannheim📍 München University Hospital Tuebingen · Tests: No intervention Standardized Clinical Assessment of Patients With Leptomeningeal Metastasis NCT06417710n/a3 sites📍 Houston📍 Amsterdam📍 Zurich University of Zurich · Tests: Neurological Assessment Efficacy and Safety of Intraventricule Pemetrexed Disodium Administered Via Ommaya Reservoir NCT06399926n/a1 site📍 Changsha Xiangya Hospital of Central South University · Tests: Pemetrexed injection, Pemetrexed Trastuzumab Deruxtecan (T-DXd) for People With Brain Cancer NCT06058988Phase 21 site📍 New York Memorial Sloan Kettering Cancer Center · Tests: Trastuzumab deruxtecan Capecitabine, Tucatinib, and Intrathecal Trastuzumab for Breast Cancer Patients With Leptomeningeal Disease NCT05800275Phase 211 sites📍 Bordeaux📍 Caen📍 Clermont-Ferrand UNICANCER · Tests: Tucatinib Oral Tablet, Capecitabine tablets, Trastuzumab Injection Evaluating High-dose Furmonertinib with Bevacizumab and Pemetrexed for EGFRm NSCLC with Leptomeningeal Metastasis NCT06643000NA2 sites📍 Zhengzhou📍 Zhengzhou Henan Cancer Hospital · Tests: furmonertinib
🛡️

AI Cure shows public evidence (Open Targets, ClinicalTrials.gov, PubMed, openFDA, DepMap, AlphaFold) with its source, and AI summaries that cite it — not medical advice and not a cure. Treatment decisions belong with your doctor. Research ideas are shared only with approved researchers and labs, who can test them. In an emergency call your local emergency number (112 in India and Europe, 911 in the US). AI Cure Terms of Use · Privacy