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Trial Match

Clinical trials test new treatments — sometimes the newest options available for a disease. Find trials that are recruiting now, near you. Open one to see its eligibility rules as simple questions to go through with your doctor.

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30 recruiting trials

for Leptomeningeal Metastasis

Neoadjuvant Stereotactic Radiotherapy for Brain Metastasis NCT06933199NA4 sites📍 Ostrava📍 Brno📍 Hradec Králové University Hospital Ostrava · Tests: Neoadjuvant Stereotactic Radiotherapy (NaSRT), Postoperative Stereotactic Radiotherapy (SRT) Proton Cranio-spinal Irradiation for Leptomeningeal Metastasis NCT05746754NA2 sites📍 Aarhus📍 Aalborg University of Aarhus · Tests: CSI Efficacy and Safety of Intrathecal Administration of Thiotepa in Combination With Methotrexate in Breast Cancer With Leptomeningeal Metastasis NCT06543992Phase 21 site📍 Nanjing The First Affiliated Hospital with Nanjing Medical Universi… · Tests: Intrathecal Administration of Thiotepa in Combination with Methotrexate via the Ommaya Reservoir Study in Patients With Breast Cancer Leptomeningeal Metastasis NCT06638294n/a2 sites📍 Washington D.C.📍 Baltimore Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins Evaluate the Safety, Tolerability, Biodistribution Characteristics and Preliminary Efficacy of BioTTT001 NCT07264569Phase 1, Phase 21 site📍 Zhengzhou Henan Cancer Hospital · Tests: BioTTT001 injection Pulsatile High-dose Furmonertinib in EGFR-mutant NSCLC With Leptomeningeal Metastasis NCT07348965NA1 site📍 Guangzhou Guangzhou University of Traditional Chinese Medicine · Tests: Furmonertinib 320mg qod po, Furmonertinib 160mg qd po Testing Proton Craniospinal Radiation Therapy Versus the Usual Radiation Therapy for Leptomeningeal Metastasis, RADIATE-LM Trial NCT06500481Phase 358 sites📍 Phoenix📍 Little Rock📍 Encinitas NRG Oncology · Tests: Biospecimen Collection, Computed Tomography, Involved-Field Radiation Therapy, Lumbar Puncture, Magnetic Resonance Imag… Efficacy and Resistance Mechanisms of IP in NSCLC With Leptomeningeal Metastases NCT06440954Phase 21 site📍 Changsha Hunan Province Tumor Hospital · Tests: Intrathecal pemetrexed Intrathecal Injection Pemetrexed And Bevacizumab in Patients With Leptomeningeal Metastases in NSCLC NCT06663306Phase 11 site📍 Shanghai Shanghai Chest Hospital · Tests: Pemetrexed, Bevacizumab CSF Analysis in EGFR Mutant Non-Small Cell Lung Cancer With Leptomeningeal Disease NCT05257967NA1 site📍 Vancouver British Columbia Cancer Agency · Tests: Lumbar puncture and Phlebotomy Furmonertinib Combined With Intrathecal Chemotherapy and Stereotactic Radiotherapy (SRT) for EGFR-Mutated NSCLC Patients With Brain Parenchymal and Leptomeningeal Metastases NCT07304739Phase 23 sites📍 Cangzhou📍 Tianjin📍 Tianjin Tianjin Medical University Cancer Institute and Hospital · Tests: Furmonertinib, Intrathecal chemotherapy, Stereotactic radiotherapy Intra-pemetrexed Plus Third-generation Small Molecule TKI Drugs (e.g. 'Osimertinib') Versus Third-generation Small Molecule TKI Drugs Alone for Leptomeningeal Metastasis From Epidermal Growth Factor Receptor Mutation-Positive Non-Small-cell Lung Cancer NCT06304441NA1 site📍 Huizhou Guangzhou Medical University · Tests: Osimertinib, Pemetrexed Zorifertinib With Osimertinib for NSCLC With Meningeal Progression NCT07361705Phase 15 sites📍 Beijing📍 Shengyang📍 Guangzhou Alpha Biopharma (Jiangsu) Co., Ltd. · Tests: Zorifertinib and Osimertinib Combination Therapy Sacituzumab Govitecan and Intrathecal Chemotherapy for Treating Leptomeningeal Metastases From Her2-negative Breast Cancer NCT06462092Phase 1, Phase 21 site📍 Huizhou Guangzhou Medical University · Tests: Sacituzumab Govitecan, Pemetrexed Exploration of the Application of Methotrexate-loaded Drug Vesicles in Intrathecal Injection for Meningeal Metastasis of Lung Cancer NCT07559097Phase 1, Phase 21 site📍 Zhengzhou Henan Cancer Hospital · Tests: Methotrexate-loaded vesicles A Study of the Safety and Efficacy of Pemetrexed Combined with Nivolumab Via Intraventricular Injection for the Treatment of Refractory Non-squamous Non-small Cell Lung Cancer with Leptomeningeal Metastases NCT06901817Phase 21 site📍 Shanghai Shanghai Cancer Hospital, China · Tests: Intraventricular Pemetrexed, Intraventricular Nivolumab, Intraventricular Dexamethasone Tumor Treating Fields for the Treatment of Leptomeningeal Metastases of the Spine in Patients With Breast or Lung Cancer NCT05746325NA1 site📍 Jacksonville Mayo Clinic · Tests: Digital Photography, Lumbar Puncture, Magnetic Resonance Imaging, Medical Device Usage and Evaluation, Biospecimen Coll… A Phase IIa Study to Evaluate NBQ72S NCT06810804Phase 21 site📍 Beijing Nantong Bencao Quadriga Medical Technology Co. Ltd. · Tests: NBQ72S Dual-targeting VEGFR1 and PD-L1 CAR-T for Pleural, Peritoneal, or Leptomeningeal Metastases NCT05477927Phase 11 site📍 Chengdu Sichuan University · Tests: Dual-targeting VEGFR1/PD-L1 CAR-T cells A Study of Deferoxamine (DFO) in People With Leptomeningeal Metastasis NCT05184816Phase 17 sites📍 Basking Ridge📍 Middletown📍 Montvale Memorial Sloan Kettering Cancer Center · Tests: Deferoxamine (DFO) Intrathecal PD-1/VEGF Bispecific Antibody Plus Pemetrexed for Leptomeningeal Metastasis NCT06809517Phase 1, Phase 21 site📍 Huizhou Guangzhou Medical University · Tests: AK112, Pemetrexed (Alimta) Hippocampal Avoidance in Craniospinal Irradiation for the Treatment of Leptomeningeal Metastases From Breast Cancer or Non-small Cell Lung Cancer NCT06518057Phase 23 sites📍 San Francisco📍 New York📍 Seattle University of Washington · Tests: Biospecimen Collection, Computed Tomography, Electronic Health Record Review, Lumbar Puncture, Magnetic Resonance Imagi… Intrathecal Pemetrexed for Leptomeningeal Metastasis in EGFR-Mutant NSCLC NCT05805631Phase 21 site📍 Taipei Taipei Veterans General Hospital, Taiwan · Tests: Pemetrexed Photon Craniospinal Irradiation for the Treatment of Leptomeningeal Disease Secondary to Breast Cancer or Non-small Cell Lung Cancer NCT06910761Phase 22 sites📍 Duarte📍 Irvine City of Hope Medical Center · Tests: Biospecimen Collection, Craniospinal Irradiation, Electronic Health Record Review, Lumbar Puncture, Magnetic Resonance … Prospective Evaluation Of High-Dose Systemic Methotrexate In Patients With Breast Cancer And Leptomeningeal Metastasis NCT02422641Phase 23 sites📍 Baltimore📍 St Louis📍 Winston-Salem Wake Forest University Health Sciences · Tests: High-dose Methotrexate (8 gm/m2; HD-MTX) Amivantamab Combined With Intrathecal Pemetrexed for LM From EGFR-Mutated Lung Adenocarcinoma NCT07744529Phase 1, Phase 21 site📍 Hangzhou Second Affiliated Hospital, Zhejiang University, School of … · Tests: Amivantamab+ systemic/ intrathecal Pemetrexed Standardized Clinical Assessment of Patients With Leptomeningeal Metastasis NCT06417710n/a3 sites📍 Houston📍 Amsterdam📍 Zurich University of Zurich · Tests: Neurological Assessment Efficacy and Safety of Intraventricule Pemetrexed Disodium Administered Via Ommaya Reservoir NCT06399926n/a1 site📍 Changsha Xiangya Hospital of Central South University · Tests: Pemetrexed injection, Pemetrexed Stupp Treatment With Intrathecal Injection of Thiotepa for Glioblastoma With Advanced Spread NCT07193654Phase 21 site📍 Hangzhou Second Affiliated Hospital, Zhejiang University, School of … · Tests: Intrathecal injection of thiotepa, Stupp regimen (oral temozolomide), Radical radiotherapy, Maximal surgical resection Trastuzumab Deruxtecan (T-DXd) for People With Brain Cancer NCT06058988Phase 21 site📍 New York Memorial Sloan Kettering Cancer Center · Tests: Trastuzumab deruxtecan
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