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Trial Match

Clinical trials test new treatments โ€” sometimes the newest options available for a disease. Find trials that are recruiting now, near you. Open one to see its eligibility rules as simple questions to go through with your doctor.

Know your stage or your test results (such as EGFR, HER2 or BRCA)? Match trials to your own profile - nothing you type is saved.

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30 recruiting trials

for Locally Advanced

Efficacy and Safety of Concurrent PD-1 Inhibitor and Radiotherapy With Immunonutrition for Esophageal Squamous Cell Carcinoma NCT06342167Phase 210 sites๐Ÿ“ Beijing๐Ÿ“ Fujian๐Ÿ“ Handan Cancer Institute and Hospital, Chinese Academy of Medical Sโ€ฆ ยท Tests: Radiotherapy, Programmed Cell Death Protein 1 Inhibitor, Immunonutrition support Dose-escalation Study to Assess Safety and Pharmacokinetics of Nab-Sirolimus in Patients With Locally Advanced or Metastatic Solid Tumors and Moderate Liver Impairment NCT05661461Phase 12 sites๐Ÿ“ San Antonio๐Ÿ“ West Valley City Aadi Bioscience, Inc. ยท Tests: nab-sirolimus Genetically-informed Therapy for ER+ Breast Cancer Post-CDK4/6 Inhibitor NCT05933395Phase 21 site๐Ÿ“ Lebanon Dartmouth-Hitchcock Medical Center ยท Tests: Fulvestrant, Neratinib, Alpelisib, Everolimus, Abemaciclib Elacestrant in Patients With ER+ HER2- ESR1-mutated Locally Advanced or Metastatic Breast Cancer NCT07563595n/a3 sites๐Ÿ“ Freiburg im Breisgau๐Ÿ“ Paderborn๐Ÿ“ Ravensburg iOMEDICO AG ยท Tests: Elacestrant, Standard of care (Investigator Choice) A Study of BL-M05D1 in Patients With Locally Advanced or Metastatic Solid Tumors NCT06349811Phase 11 site๐Ÿ“ Beijing Sichuan Baili Pharmaceutical Co., Ltd. ยท Tests: BL-M05D1 Laparoscopic Gastrectomy With D2 Lymphadenectomy Combined With Hyperthermic Intraperitoneal Chemotherapy (HIPEC) or Not NCT05871099Phase 31 site๐Ÿ“ Qingdao The Affiliated Hospital of Qingdao University ยท Tests: Hyperthermic Intraperitoneal Chemotherapy (HIPEC) Cardiovascular Injury and Cardiac Fitness in Locally Advanced Non-Small Cell Lung Cancer Patients Receiving Model Based Personalized Chemoradiation NCT05010109NA1 site๐Ÿ“ Houston M.D. Anderson Cancer Center ยท Tests: 6 Minute Walk Functional Test, Biospecimen Collection, Computed Tomography, Echocardiography, Exercise Cardiac Stress Tโ€ฆ Neoadjuvant Iparomlimab and Tuvonralimab Plus Chemotherapy-eclipse for Locally Advanced Cervical Cancer (NICE-CC) NCT07055399Phase 21 site๐Ÿ“ Fuzhou Fujian Cancer Hospital ยท Tests: neoadjuvant chemo-immunotherapy: Iparomlimab and tuvonralimab plus cisplatin,nab-paclitaxel for 1 cycle and Iparomlimabโ€ฆ FOLFOX Combined With Durvalumab (MEDI4736), Bevacizumab, and Stereotactic Body Radiotherapy in Sequential Treatment of Potentially Resectable Locally Advanced Hepatocellular Carcinoma NCT07012798Phase 21 site๐Ÿ“ Tianjin Tianjin Medical University Cancer Institute and Hospital ยท Tests: Durvalumab, Bevacizumab, HAIC of FOLFOX ACE2016 in Adult Subjects With Locally Advanced or Metastatic Solid Tumors Expressing Epidermal Growth Factor Receptor (EGFR) NCT06415487Phase 19 sites๐Ÿ“ San Diego๐Ÿ“ Denver๐Ÿ“ Nashville Acepodia Biotech, Inc. ยท Tests: Cyclophosphamide, Fludarabine, ACE2016, Pembrolizumab Study Evaluating DNA Double-strand Breaks (DSBs) REpair Factors (POLQ, Shieldin Complex and 53BP1) Expression as Biomarker of PARP Inhibitor Resistance in Patients With Deleterious Germline Mutation in BRCA 1/2 and HER2-negative, Metastatic or Locally Advanced Breast Cancer. NCT05378204NA25 sites๐Ÿ“ Bordeaux๐Ÿ“ Caen๐Ÿ“ Clermont-Ferrand Institut Claudius Regaud ยท Tests: Main study:, Sub-study: A Study to Investigate ANS03 in Participants With Locally Advanced or Metastatic Solid Tumors NCT06716138Phase 15 sites๐Ÿ“ New York๐Ÿ“ Fuzhou๐Ÿ“ Guangzhou Avistone Biotechnology Co., Ltd. ยท Tests: ANS03 Fluorescence Image Guided Surgery Followed by Intraoperative Photodynamic Therapy for Improving Local Tumor Control in Patients With Locally Advanced or Recurrent Colorectal Cancer NCT06307548Phase 1, Phase 21 site๐Ÿ“ Buffalo Roswell Park Cancer Institute ยท Tests: Aminolevulinic Acid, Biospecimen Collection, Computed Tomography, Fluorescence-Guided Surgery, Magnetic Resonance Imagiโ€ฆ Perioperative Chemotherapy Combined With Serplulimab or Placebo for pMMR Locally Advanced Gastric Adenocarcinoma (FOCUS-05) NCT05872685Phase 25 sites๐Ÿ“ Hangzhou๐Ÿ“ Hangzhou๐Ÿ“ Lishui Yu jiren ยท Tests: S1, Oxaliplatin, Serplulimab, Placebo A Study of GNC-077 in Patients With Locally Advanced or Metastatic Breast Cancer and Other Solid Tumors NCT06609187Phase 11 site๐Ÿ“ Beijing Sichuan Baili Pharmaceutical Co., Ltd. ยท Tests: GNC-077 cDNA and Residual Disease After Chemoradiotherapy for Locally Advanced Head and Neck Squamous Cell Carcinomas NCT07178847NA4 sites๐Ÿ“ Aurillac๐Ÿ“ Clermont-Ferrand๐Ÿ“ Lyon Centre Jean Perrin ยท Tests: blood sampling Safety and Early Efficacy of Radical Prostatectomy for Newly Diagnosed Very High Risk Locally Advanced and Oligometastatic Prostate Cancer NCT02971358NA1 site๐Ÿ“ Vienna Medical University of Vienna ยท Tests: Radical prostatectomy A Phase I Study of CFT8919 in Patients With Advanced NSCLC NCT06641609Phase 11 site๐Ÿ“ Hangzhou Betta Pharmaceuticals Co., Ltd. ยท Tests: Dose-Escalation (Phase Ia) CFT8919 capsule, Dose-Expansion (Phase Ib) CFT8919 capsule, Cohort-Expansion (Phase Ic) CFT8โ€ฆ PRO-BOOST-LC: Whole-Gland Boost Strategies Versus SBRT Monotherapy in PSMA-Staged Localized and Locally Advanced Prostate Cancer NCT07426055Phase 2, Phase 31 site๐Ÿ“ Zamoล›ฤ‡ Affidea Nu-med Center of Oncological DIagnostics and Therapy ยท Tests: Stereotactic Body Radiotherapy (SBRT) Monotherapy, External Beam Radiotherapy (EBRT) Backbone, High-Dose-Rate Brachytheโ€ฆ A Study of Zipalertinib in Patients With Advanced Non-Small Cell Lung Cancer With Epidermal Growth Factor Receptor (EGFR) Exon 20 Insertions or Other Uncommon Mutation. NCT05967689Phase 280 sites๐Ÿ“ Birmingham๐Ÿ“ Duarte๐Ÿ“ Boston Taiho Oncology, Inc. ยท Tests: TAS6417, CYP Cocktail, Transporter Cocktail Prospective Study on Radiation Induced Cardiotoxicity Assessed By PET-CT for Locally Advanced Non-Small Cell Lung Cancer (NSCLC) NCT07761910Phase 21 site๐Ÿ“ Indianapolis Indiana University ยท Tests: PET/CT 18F-Flurpiridaz Rest/Stress Test, Coronary CT Angiography (CCTA), 18F-Flurpiridaz A Study of CEND-1 With Chemotherapy as First-Line Therapy in Patients With Pancreatic Ductal Adenocarcinoma NCT06261359Phase 21 site๐Ÿ“ Beijing Qilu Pharmaceutical Co., Ltd. ยท Tests: CEND-1, Gemcitabine, Nab paclitaxel Adebrelimab ยฑInduction Chemotherapy Followed by Concurrent Chemoradiotherapy for Unresectable Locally Advanced ESCC NCT06510660Phase 21 site๐Ÿ“ Fuzhou Fujian Medical University Union Hospital ยท Tests: adebrelimab Prediction of Neoadjuvant Chemotherapy Efficacy in Locally Advanced Gastric Cancer NCT05140746NA1 site๐Ÿ“ Shanghai Ruijin Hospital ยท Tests: 68Ga-FAPI-04 PET/CT and 18F-FDG PET/CT Envafolimab Combined With Chemoradiotherapy and Recombinant Human Endostatin for LA-NPC. NCT06059261Phase 21 site๐Ÿ“ Chongqing Chongqing University Cancer Hospital ยท Tests: Envafolimab and recombinant human endostatin combined with chemoradiotherapy Master Protocol of TCR-modified T Cell Therapy Targeting HLA-restricted KRAS Antigen Administered in Adult Patients With Metastatic or Locally Advanced PDAC NCT07145450Phase 1, Phase 210 sites๐Ÿ“ Copenhagen๐Ÿ“ Berlin๐Ÿ“ Dresden Anocca AB ยท Tests: ANOC-001 (TCR-T cells targeting KRAS G12V mutation presented by specific HLA alleles), ANOC-002 (TCR-T cells targeting โ€ฆ CD8 PET Imaging in Metastatic Solid Tumours NCT06534190Phase 24 sites๐Ÿ“ Amsterdam๐Ÿ“ Groningen๐Ÿ“ Barcelona University Medical Center Groningen ยท Tests: 89Zr-Df-crefmirlimab PET scan, Nivolumab, Cetrelimab, zirconium Zr 89 crefmirlimab berdoxam A Multicenter Randomized Controlled Phase II Trial of Iparomlimab and Tuvonralimab (QL1706) Combined With SOX Chemotherapy Versus Chemotherapy Alone in the Treatment of Locally Advanced Gastric or Gastroesophageal Junction Adenocarcinoma NCT06829797Phase 21 site๐Ÿ“ Jinan Shandong Provincial Hospital ยท Tests: Neoadjuvant Therapy(QL1706+SOX Chemotherapy), Neoadjuvant Therapy(SOX Chemotherapy), Radical surgery (D2), Drug: Adjuvaโ€ฆ Neoadjuvant of Sintilimab Combined Weekly Metronomic Chemotherapy (PLOF) for Resectable Locally Advanced Gastric Cancer NCT06054906Phase 21 site๐Ÿ“ Shanghai Huashan Hospital ยท Tests: sintilimab+metronomic PLOF FDG PET-CT in Advanced Breast Cancer NCT07173868n/a1 site๐Ÿ“ Seoul Samsung Medical Center
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