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Trial Match

Clinical trials test new treatments โ€” sometimes the newest options available for a disease. Find trials that are recruiting now, near you. Open one to see its eligibility rules as simple questions to go through with your doctor.

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30 recruiting trials

for Locally Advanced Colorectal Carcinoma

Fluorescence Image Guided Surgery Followed by Intraoperative Photodynamic Therapy for Improving Local Tumor Control in Patients With Locally Advanced or Recurrent Colorectal Cancer NCT06307548Phase 1, Phase 21 site๐Ÿ“ Buffalo Roswell Park Cancer Institute ยท Tests: Aminolevulinic Acid, Biospecimen Collection, Computed Tomography, Fluorescence-Guided Surgery, Magnetic Resonance Imagiโ€ฆ Exploring the Treatment Duration of PD-1 Neoadjuvant Therapy in Stage II-III dMMR Rectal Cancer NCT06613165n/a1 site๐Ÿ“ Xi'an Xijing Hospital Nanoliposomal Irinotecan, Oxaliplatin Plus Capecitabine As Conversion Therapy of Locally Advanced Colorectal Cancer NCT06405139Phase 21 site๐Ÿ“ Beijing Cancer Institute and Hospital, Chinese Academy of Medical Sโ€ฆ ยท Tests: Nanoliposomal Irinotecan, Oxaliplatin plus Capecitabine The Efficacy of Watch and Wait Strategy or Surgery After Neoadjuvant Immunotherapy for Locally Advanced Colorectal Cancer With dMMR/MSI-H Guided by MRD Dynamic Monitoring: A Single-center, Open-label, Prospective, Phase II Clinical Trial. NCT06477991n/a1 site๐Ÿ“ Kunming Yunnan Cancer Hospital ยท Tests: Tireilizumab๏ผˆPD-1 inhibitor๏ผ‰ Avapritinib for the Treatment of CKIT or PDGFRA Mutation-Positive Locally Advanced or Metastatic Malignant Solid Tumors NCT04771520Phase 21 site๐Ÿ“ Houston M.D. Anderson Cancer Center ยท Tests: Avapritinib Adebrelimab Injection (PD-L1) Combined With Short Course Radiotherapy and Chemotherapy for Neoadjuvant Therapy of Locally Advanced Rectal Cancer NCT06765616Phase 21 site๐Ÿ“ Jinan Feng Tian ยท Tests: Adebrelimab Injection combined with radiotherapy and chemotherapy mFOLFOX6 + Bevacizumab + PD-1 Monoclonal Antibody Vs. mFOLFOX6 in Locally Advanced pMMR/MSS CRC NCT06791512Phase 31 site๐Ÿ“ Guangzhou Jun Huang ยท Tests: mFOLFOX6 + Bevacizumab + PD-1 monoclonal antibody, mFOLFOX6 Trifluridine/Tipiracil and Talazoparib for the Treatment of Patients With Locally Advanced or Metastatic Colorectal or Gastroesophageal Cancer NCT04511039Phase 11 site๐Ÿ“ Buffalo Roswell Park Cancer Institute ยท Tests: Trifluridine and Tipiracil Hydrochloride, Talazoparib Tosylate First-in-human Trial of STC-1010, an Immunotherapy, in Patients With Unresectable Locally Advanced or Metastatic Colorectal Cancer NCT06934538Phase 1, Phase 29 sites๐Ÿ“ Baltimore๐Ÿ“ Brussels๐Ÿ“ Bordeaux Brenus Pharma ยท Tests: STC-1010 + IS regimen + SOC therapy A Phase 1 Study of TGI-5 as Monotherapy and in Combination With Nivolumab in Subjects With Locally Advanced/Metastatic Solid Tumors NCT07376707Phase 11 site๐Ÿ“ Shanghai Hefei TG ImmunoPharma Co., Ltd. ยท Tests: TGI-5 A Study of ASP546C in Adults With Gastroesophageal Cancer, Pancreatic Cancer or Other Solid Tumors NCT07488676Phase 1, Phase 221 sites๐Ÿ“ Birmingham๐Ÿ“ Los Angeles๐Ÿ“ Miami Astellas Pharma Global Development, Inc. ยท Tests: ASP546C A Study of IDE034 in Adult Participants With Locally Advanced/Metastatic Solid Tumors Types NCT07503808Phase 115 sites๐Ÿ“ Denver๐Ÿ“ Sarasota๐Ÿ“ Detroit IDEAYA Biosciences ยท Tests: IDE034 Neoadjuvant Treatment of Fulzerasib Plus Cetuximab N01 in KRAS G12C Mutated Locally Advanced Colorectal Cancer With or Without Resectable Metastases NCT07581912Phase 21 site๐Ÿ“ Hangzhou Zhejiang University ยท Tests: fulzerasib; cetuximab N01 A FIH, Phase I/IIa, Trial Assessing Feasibility of Administrations of TIL-based Immunotherapy in Patients With Metastatic CRC and PC NCT07255664Phase 1, Phase 21 site๐Ÿ“ Frankfurt CuraCell TX AB ยท Tests: CC-38, Pembrolizumab, Cyclophosphamid, Interleukin-2, Uromitexan Adaptive Radiation in Anal Cancer NCT05838391NA1 site๐Ÿ“ New York Columbia University ยท Tests: Artificial Intelligence Guided Daily Radiotherapy Treatment Planning and Delivery, Mitomycin-C, 5-Fluorouracil, Capecitโ€ฆ A Study of BL-M17D1 in Patients With Locally Advanced or Metastatic HER2 Positive/Lower Expression Gastrointestinal Cancer and Other Solid Tumors NCT06500052Phase 11 site๐Ÿ“ Guangzhou Sichuan Baili Pharmaceutical Co., Ltd. ยท Tests: BL-M17D1 Study to Evaluate the Use of Capecitabine in Monotherapy and in Combination With Oxaliplatin in Elderly Patients as Adjuvant Chemotherapy for Locally Advanced Colorectal Cancer. NCT06888843Phase 21 site๐Ÿ“ Nizhny Novgorod Nizhny Novgorod Regional Clinical Oncology Center ยท Tests: Capecitabine, Oxaliplatin A Study of KIVU-107 in Participants With Locally Advanced or Metastatic Solid Tumors NCT07229313Phase 17 sites๐Ÿ“ Santa Monica๐Ÿ“ New Have๐Ÿ“ Camperdown Kivu Bioscience Inc. ยท Tests: KIVU-107 Cemiplimab With or Without Fianlimab to Treat Older Patients With Localized or Locally Advanced MSI-H Colorectal Cancer NCT06205836Phase 21 site๐Ÿ“ Baltimore Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins ยท Tests: Cemiplimab, Fianlimab Different Cycles of Preoperative Neoadjuvant Sintilimab in Mismatch-repair Deficient/microsatellite Instability-high, Locally Advanced Colorectal Cancer NCT06698757Phase 21 site๐Ÿ“ Zheng'zhou Yugui Lian ยท Tests: Sintilimab Isunakinra Alone and in Combination With Pembrolizumab in Patients With Colorectal Cancer (MSS) NCT06634875Phase 23 sites๐Ÿ“ Los Angeles๐Ÿ“ Newport Beach๐Ÿ“ Atlanta Buzzard Pharmaceuticals ยท Tests: isunakinra A Study of MRG007 (ARR-217) in Patients With Advanced Solid Tumors NCT07066657Phase 121 sites๐Ÿ“ Los Angeles๐Ÿ“ San Francisco๐Ÿ“ Aurora ArriVent BioPharma, Inc. ยท Tests: MRG007, MRG007 and Bevacizumab A Study of KIVU-305 in Participants With Locally Advanced or Metastatic Solid Tumors NCT07545356Phase 13 sites๐Ÿ“ Sydney๐Ÿ“ Wollongong๐Ÿ“ Brisbane Kivu Bioscience Inc. ยท Tests: KIVU-305 A Study to Find a Suitable Dose of ASP5834 in Adults With Solid Tumors NCT07094204Phase 120 sites๐Ÿ“ Santa Monica๐Ÿ“ Atlanta๐Ÿ“ Jefferson Astellas Pharma Inc ยท Tests: ASP5834, panitumumab Organ Preservation in Rectal Cancer: Contact X-ray Brachytherapy vs Extending the Waiting Interval and Local Excision NCT05772923NA7 sites๐Ÿ“ Nijmegen๐Ÿ“ Eindhoven๐Ÿ“ Amsterdam The Netherlands Cancer Institute ยท Tests: Contact x-ray brachytherapy, Local excision Neoadjuvant Toripalimab With or Without Celecoxib in dMMR/MSI-H Colorectal Cancer NCT03926338Phase 21 site๐Ÿ“ Guangzhou Sun Yat-sen University ยท Tests: Neoadjuvant toripalimab plus celecoxib for 6 cycles, Neoadjuvant toripalimab monotherapy for 6 cycles, Neoadjuvant toriโ€ฆ EBNK-001 Allogeneic NK Cells With Low-Dose IL-15 ยฑ Pembrolizumab in Advanced Solid Tumors NCT07410676Phase 1, Phase 21 site๐Ÿ“ Beijing Essen Biotech ยท Tests: EBNK-001 + IL-15 + Pembrolizumab A Study of a Selective T Cell Receptor (TCR) Targeting, Bifunctional Antibody-fusion Molecule STAR0602 in Participants With Advanced Solid Tumors NCT05592626Phase 1, Phase 219 sites๐Ÿ“ Sacramento๐Ÿ“ Celebration๐Ÿ“ Miami Marengo Therapeutics, Inc. ยท Tests: STAR0602, Irinotecan (Camptosar), Docetaxel (Taxotere) FOG-001 in Locally Advanced or Metastatic Solid Tumors NCT05919264Phase 1, Phase 233 sites๐Ÿ“ Phoenix๐Ÿ“ Scottsdale๐Ÿ“ Tucson Parabilis Medicines, Inc. ยท Tests: FOG-001, mFOLFOX-6, Nivolumab, Trifluridine/tipiracil, Bevacizumab Modulated Electro-Hyperthermia in Combination With Multimodal Therapy for Locally Advanced Rectal Cancer NCT07372300Phase 31 site๐Ÿ“ Chiayi City Shih-Kai Hung ยท Tests: Hyperthermia
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