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Trial Match

Clinical trials test new treatments — sometimes the newest options available for a disease. Find trials that are recruiting now, near you. Open one to see its eligibility rules as simple questions to go through with your doctor.

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30 recruiting trials

for Treatment Resistant Depression

The Effect of a Six Week Intensified Pharmacological Treatment for Major Depressive Disorder Compared to Treatment as Usual in Subjects Who Had a First-time Treatment Failure on Their First-line Treatment. NCT05973851Phase 312 sites📍 Innsbruck📍 Bielefeld📍 Dortmund Dr. Inge Winter · Tests: Esketamine Nasal Product, Ketamine Hydrochloride, Esketamine hydrochloride, Second-line Antidepressants Psilocybin Intervention for Veterans Overcoming Treatment-Resistant Depression NCT07226232Phase 35 sites📍 Birmingham📍 Tuscaloosa📍 Portland VA Office of Research and Development · Tests: Psilocybin, Psilocybin University of Iowa Interventional Psychiatry Service Patient Registry NCT04480918n/a1 site📍 Iowa City Mark Niciu · Tests: Electroconvulsive Therapy (ECT), Transcranial Magnetic Stimulation (TMS), Ketamine, Esketamine, Deep Transcranial Magne… rTMS With and Without Text4Support for the Treatment of Resistant Depression. NCT05570344NA2 sites📍 Edmonton📍 Halifax University of Alberta · Tests: Repetitive Transcranial Magnetic Stimulation (rTMS), Repetitive Transcranial Magnetic Stimulation (rTMS) Plus Text4Supp… Identifying Local Field Potential Biomarkers for Treatment-Resistant Major Depression With Deep Brain Stimulation NCT06542094NA1 site📍 Chengdu West China Hospital · Tests: Deep Brain stimulation Evaluation of Deep Brain Stimulation (DBS) of the Right Operculum 3 (OP3) in Permanent Non-pulsatile Disabling Tinnitus (TINNOP3-DBS) NCT04296097NA1 site📍 Grenoble University Hospital, Grenoble · Tests: DBS Mapping and Modulating the Spatiotemporal Dynamics of Socio-Affective Processing NCT05418894NA1 site📍 Houston Baylor College of Medicine · Tests: Device: Directional Deep Brain Stimulation InTRavenous kEtAmine and immerSive virtUal Reality to Treat dEpression NCT06781697Phase 31 site📍 Toronto Sunnybrook Health Sciences Centre · Tests: Ketamine, Oculus VR headset Effects of a Classic High-frequency rTMS Treatment Versus a Deep rTMS Treatment NCT04956016NA1 site📍 Poitiers Centre Hospitalier Henri Laborit · Tests: classic rTMS using the 8-shaped coil, deep rTMS using the H1-shaped coil The Impact of Working Memory and Reward Markers on DLPFC Activity in Treatment-resistant Depression NCT06163625NA1 site📍 Toronto Unity Health Toronto · Tests: Repetitive Transcranial Magnetic Stimulation, Research Interview, Questionnaires, Brain Scan, Saliva Samples Maintenance rTMS for Depression (Maitr-De) NCT06938841NA3 sites📍 San Diego📍 New York📍 Canberra University of California, San Diego · Tests: Transcranial Magnetic Stimulation (TMS) - Standard maintenance rTMS:, Transcranial Magnetic Stimulation (TMS) - Cluster… A Randomized, Double-Blind Controlled Comparison of NRX-101 vs. Placebo for Adults Being Treated With Robotic Transcranial Magnetic Stimulation for Treatment Resistant Depression: The SPARC-TMS Trial NCT07227103Phase 2, Phase 33 sites📍 Sarasota📍 West Palm Beach📍 Belmont NeuroRx, Inc. · Tests: Neuronavigated robotic-enabled TMS, NRX-101, Sham TMS, Oral Placebo DBS for Depression NCT06096207Phase 11 site📍 Queens Northwell Health · Tests: Medtronic SenSight Directional DBS lead Medical Phenotyping of NHS General Adult Psychiatry (GAP) Inpatients NCT07398365n/a1 site📍 Livingston University of Edinburgh · Tests: Questionnaires, rating scales, & review of notes Deep Phenotyping for Clinical Inferring Response in Treatment Resistant Depression NCT06396312n/a1 site📍 Munich Max-Planck-Institute of Psychiatry Psilocybin rTMS for Treatment Resistant Depression NCT06132178Phase 21 site📍 Austin University of Texas at Austin · Tests: Psilocybin, Accelerated intermittent theta burst (aiTBS) rTMS treatment, Low-dose psilocybin, Sham Accelerated intermit… Brexpiprazole Treatment for Bipolar I Depression NCT04569448Phase 33 sites📍 Hamilton📍 Montreal📍 Montreal Douglas Mental Health University Institute · Tests: Brexpiprazole Treatment ResistAnt Depression Subcallosal CingulatE Network DBS (TRANSCEND) NCT06423430NA26 sites📍 Birmingham📍 Los Angeles📍 Los Angeles Abbott Medical Devices · Tests: Sham-stimulation, Active-stimulation Adjunctive Allogeneic Mesenchymal Stem Cells for Treatment-resistant Bipolar Depression NCT03522545Phase 11 site📍 Houston The University of Texas Health Science Center, Houston · Tests: Allogeneic Bone Marrow Derived Multipotent Mesenchymal Stromal Cells (MSCs), Placebo ACP-211 Monotherapy for Major Depressive Disorder With Inadequate Antidepressant Response NCT07284667Phase 228 sites📍 Birmingham📍 Chino📍 Glendale ACADIA Pharmaceuticals Inc. · Tests: ACP-211, Placebo Interleaved TMS-fMRI in Ultra-treatment Resistant Depression NCT05813093NA1 site📍 Toronto Sunnybrook Health Sciences Centre · Tests: rTMS ipRGC as a Potential Biomarker for Predicting Transcranial Magnetic Stimulation Treatment Response in Major Depressive Disorder NCT07474974NA1 site📍 Porto Polytechnic Institute of Porto · Tests: Repetitive transcranial magnetic stimulation (rTMS) Establishing Mobile Transcranial Magnetic Stimulation NCT06748209Phase 41 site📍 Charleston Medical University of South Carolina · Tests: Left prefrontal Transcranial Magnetic Stimulation (TMS), FDA cleared TMS for treating depression Long-term Observation of Participants With Mood Disorders NCT04877977n/a1 site📍 Bethesda National Institute of Mental Health (NIMH) French Minds Cohort: a French Longitudinal and Multimodal Cohort of Patients With Major Mood Disorders, Psychotic Disorders, Autism Spectrum Disorders, and Healthy Controls NCT07881016NA17 sites📍 Besançon📍 Bordeaux📍 Brest Fondation FondaMental · Tests: 3T Brain MRI, Biological Sampling, Clinical, Cognitive and Digital Assessments Psilocybin Microdosing With Psychotherapy for Treatment-Resistant Depression NCT07183748Phase 21 site📍 Beersheba Beersheva Mental Health Center · Tests: Psilocybin (drug), Placebo Ketamine With Dialectical Behavioural Therapy (DBT) for Suicidality in Individuals With Treatment-Resistant Depression and Borderline Personality Disorder (KET-DBT) NCT07569198Phase 21 site📍 Toronto Joshua Rosenblat · Tests: Ketamine Hydrochloride, Midazolam Hydrochloride, Dialectical Behavioral Therapy (DBT) Magnetic Resonance-Guided Focused Ultrasound Bilateral Capsulotomy for the Treatment of Refractory Bipolar Depression NCT07108257NA1 site📍 Toronto Sunnybrook Health Sciences Centre · Tests: ExAblate Neuro 4000 Olfactory and Brain Stimulations in Treatment-resistant Depression NCT05661383NA1 site📍 Bron Hôpital le Vinatier · Tests: Non-invasive brain stimulation protocol (intermittent theta burst protocol (iTBS)) combined with pleasant odors deliver… Coaching as an Adjunct to Ketamine Therapy for Treatment-Resistant Depression NCT07563868NA2 sites📍 Boston📍 Boston Massachusetts General Hospital · Tests: Psychedelic Integration Coaching
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