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Trial Match

Clinical trials test new treatments — sometimes the newest options available for a disease. Find trials that are recruiting now, near you. Open one to see its eligibility rules as simple questions to go through with your doctor.

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23 recruiting trials

for WHO Grade 3 Glioma

Local, Targeted Therapy With Alpha Emitter [225Ac]Ac-DOTA-SP (TAT) in Glioma (WHO G3-G4) Progression NCT06975332NA2 sites📍 Warsaw📍 Warsaw Medical University of Warsaw · Tests: Local, targeted therapy with alpha emitter [225Ac]Ac-DOTA-SP (TAT) A Study of the Drugs Selumetinib vs. Carboplatin and Vincristine in Patients With Low-Grade Glioma NCT04166409Phase 3132 sites📍 Birmingham📍 Mesa📍 Phoenix National Cancer Institute (NCI) · Tests: Biospecimen Collection, Carboplatin, Echocardiography Test, Magnetic Resonance Imaging, Questionnaire Administration Triapine in Combination With Temozolomide for the Treatment of Patients With Recurrent Glioblastoma NCT06410248Phase 11 site📍 Chicago Northwestern University · Tests: Biospecimen Collection, Magnetic Resonance Imaging, Questionnaire Administration, Resection, Temozolomide Lorlatinib for Newly-Diagnosed High-Grade Glioma With ROS or ALK Fusion NCT06333899EARLY Phase 118 sites📍 Aurora📍 Washington D.C.📍 Chicago Nationwide Children's Hospital · Tests: Lorlatinib, Lorlatinib with chemotherapy1, Lorlatinib with chemotherapy 2, Lorlatinib post Radiation Chronic CED of TPT for Recurrent Malignant Glioma NCT06666712Phase 11 site📍 New York Jeffrey N. Bruce · Tests: Topotecan Customized Neuro-Imaging Referenced Symptom Video for the Reduction of Patient and Caregiver Anxiety Around Radiation Treatment for Brain Tumors NCT04479696NA1 site📍 Houston M.D. Anderson Cancer Center · Tests: Educational Intervention, Questionnaire Administration, Survey Administration, Video Trametinib and Everolimus for Treatment of Pediatric and Young Adult Patients With Recurrent Gliomas (PNOC021) NCT04485559Phase 117 sites📍 Birmingham📍 Los Angeles📍 San Diego University of California, San Francisco · Tests: Everolimus, Trametinib An Investigational Scan (Ga-68 PSMA-11 PET/CT) for Detection of Disease Recurrence or Progression in Patients With Glioma NCT06444412Phase 21 site📍 Rochester Mayo Clinic · Tests: Computed Tomography, Electronic Health Record Review, Ga 68 PSMA-11, Positron Emission Tomography Study of Ribociclib and Everolimus in HGG and DIPG or Ribociclib and Temozolomide in DHG, H3G34-mutant NCT05843253Phase 220 sites📍 Aurora📍 Washington D.C.📍 Chicago Nationwide Children's Hospital · Tests: Ribociclib, Everolimus, Temozolomide (TMZ) Serial MR Imaging and MR Spectroscopic Imaging for the Characterization of Lower Grade Glioma NCT04540107Phase 11 site📍 San Francisco Susan Chang · Tests: Hyperpolarized Carbon C 13 Pyruvate, Magnetic Resonance Imaging, Magnetic Resonance Spectroscopic Imaging 5-Aminolevulinic Acid for Photodynamic Diagnosis of Malignant Glioma NCT06160492Phase 32 sites📍 Guangzhou📍 Zhengzhou Lee's Pharmaceutical Limited · Tests: 5-Aminolevulinic Acid Hydrochloride Powder for Oral Solution Chemotherapy and Radiation Therapy for the Treatment of IDH Wildtype Gliomas or Non-histological (Molecular) Glioblastomas NCT04623931Phase 21 site📍 Houston M.D. Anderson Cancer Center · Tests: Quality-of-Life Assessment, Questionnaire Administration, Radiation Therapy, Temozolomide A Study of RNA-lipid Particle (RNA-LP) Vaccines for Newly Diagnosed Pediatric High-Grade Gliomas (pHGG) and Adult Glioblastoma (GBM) NCT04573140Phase 12 sites📍 Washington D.C.📍 Gainesville University of Florida · Tests: Autologous total tumor mRNA and pp65 full length (fl) lysosomal associated membrane protein (LAMP) mRNA loaded DOTAP li… Combination Therapy for the Treatment of Diffuse Midline Gliomas NCT05009992Phase 232 sites📍 Birmingham📍 Los Angeles📍 San Diego University of California, San Francisco · Tests: ONC201, Radiation Therapy, Paxalisib, DNX-2401 Safety and Efficacy Study of Safusidenib in Participants With IDH1-Mutant Glioma Who Discontinued Vorasidenib Treatment Due to Progressive Disease NCT07703436Phase 212 sites📍 Los Angeles📍 San Francisco📍 New Haven Nuvation Bio Inc. · Tests: Safusidenib ONC206 for Treatment of Newly Diagnosed, Recurrent Diffuse Midline Gliomas, and Other Recurrent Malignant CNS Tumors NCT04732065Phase 17 sites📍 San Francisco📍 Washington D.C.📍 Atlanta Sabine Mueller, MD, PhD · Tests: ONC206, Standard of Care Radiation Therapy, Optional Proton (1H) MR spectroscopy (MRS) A Study of Zedoresertib (Debio 0123) in Combination With Temozolomide in Adult Participants With Recurrent or Progressive Glioblastoma and of Zedoresertib (Debio 0123) in Combination With Temozolomide and Radiotherapy in Adult Participants With Newly Diagnosed Glioblastoma NCT05765812Phase 1, Phase 216 sites📍 Chicago📍 New York📍 New York Debiopharm International SA · Tests: Zedoresertib, Temozolomide, Radiotherapy Prospective Surgical Study on the Pattern of Electrical Activity in High Grade Glioma as a Predictor of Progression NCT05565118Phase 11 site📍 Cleveland Case Comprehensive Cancer Center · Tests: Standard Surgical Treatment, Intraoperative Electrocorticography Anti-GARP Chimeric Antigen Receptor T Cell Therapy for the Treatment of Recurrent Grade III or IV Gliomas NCT06964737Phase 11 site📍 Columbus Ohio State University Comprehensive Cancer Center · Tests: Anti-GARP Chimeric Antigen Receptor-T Cells, Biospecimen Collection, Chest Radiography, Echocardiography Test, Magnetic… First in Human Multicenter Open Name Dose-increase, Consolidation Method to Study Safety Drug-level in Blood & Drug Metabolism Clinical Activity of Oral JBI-778 in Lung Cancer Patients With, Without Brain Metastasis IDH Mutated WHO Grade 3,4 Recurrent Glioma, Salivary Glands Tumor NCT07755397Phase 16 sites📍 Surat📍 Bangalore📍 Mumbai Jubilant Therapeutics India Limited · Tests: JBI-778 Proton vs. Photon Radiotherapy for Patients With WHO Grade 2-3 Glioma NCT07750457NA2 sites📍 Essen📍 Giessen University Hospital, Essen · Tests: Proton therapy, Photon therapy Targeted Pediatric High-Grade Glioma Therapy NCT05839379n/a22 sites📍 Aurora📍 Washington D.C.📍 Miami Nationwide Children's Hospital Study of Olutasidenib and Temozolomide in HGG NCT06161974Phase 220 sites📍 Aurora📍 Washington D.C.📍 Miami Rigel Pharmaceuticals · Tests: Olutasidenib + TMZ
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