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🗺️ Disease Atlas · Nervous system disorder

central nervous system toxicity

Toxicity that causes injury to the central nervous system or damages its function. This can include stroke, multiple sclerosis, encephalopathy, dementia, Alzheimer's disease, dyskinesia, tremor, convulsions and Parkinson's disease.

🔔 Follow weekly
🧬4genes / proteins with evidence
💊0drugs and clinical candidates
🧪12+recruiting trials worldwide
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Understand central nervous system toxicity

Every other disease · Genes, environment and time
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What it is

Toxicity that causes injury to the central nervous system or damages its function. This can include stroke, multiple sclerosis, encephalopathy, dementia, Alzheimer's disease, dyskinesia, tremor, convulsions and Parkinson's disease.

From the Open Targets disease record ↗

🔬 Every other disease: Most diseases come from a mix of the genes we inherit, the environment and way we live, and the passing of time.

❓ Why it happens

  • Genes can make a person more or less likely to get a disease.
  • Environment and lifestyle - infections, diet, smoking, pollution, activity - push the risk up or down.
  • Errors build up in the body over the years, which is why many diseases are more common with age.

🫀 What it does to the body

  • Each disease affects the body in its own way; the summary above explains this one.

🧱 Why it is hard to cure

  • The biology is often only partly understood.
  • A medicine has to be both effective and safe, and proving that in clinical trials takes years.

🚀 What research is trying now

  • Studying which genes are linked to the disease - AI Cure shows them below, ranked by evidence.
  • Testing whether medicines approved for other diseases could help.

General information about every other disease, reviewed by people; it does not describe any one person. Below: the evidence for central nervous system toxicity itself.

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AI briefing

Where the science on central nervous system toxicity stands, from the evidence on this page

AI reads the targets, drugs, trials and papers below and writes where the science stands — every claim cited. It is shared with everyone who opens central nervous system toxicity.

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Top targets

Genes and proteins ranked by Open Targets evidence (0-1)
GOT1 glutamic-oxaloacetic transaminase 1PROTACsmall molecule🧊 AlphaFold structure ↗ 0.00
GPT glutamic--pyruvic transaminasePROTAC🧊 AlphaFold structure ↗ 0.00
ALB albuminPROTACantibodysmall molecule🧊 AlphaFold structure ↗ 0.00
ORM1 orosomucoid 1antibodysmall molecule🧊 AlphaFold structure ↗ 0.00

Green labels: what the target is known to be druggable by. The score combines genetics, somatic mutations, drugs, expression and literature.

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Drugs and candidates

Every medicine linked to central nervous system toxicity, by how far it has got

No drugs recorded yet.

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Recruiting trials

Worldwide, open to new patients now
Rare Disease Patient Registry & Natural History Study - Coordination of Rare Diseases at SanfordNCT01793168 · n/a · 📍 Sioux FallsThe MOMENTUM Study: The Multiple Outcome Evaluation of Radiation Therapy Using the MR-Linac StudyNCT04075305 · n/a · 📍 PittsburghCognitive Function After Radiation Therapy for Primary Brain TumoursNCT04306432 · n/a · 📍 CopenhagenNeurocognitive Impact of Different Irradiation Modalities for Patients With Grade I-II Skull Base Meningioma:NCT06036706 · NA · 📍 CaenNeoadjuvant Stereotactic Radiotherapy for Brain MetastasisNCT06933199 · NA · 📍 OstravaStandard Follow-up Program Neuro-oncology Patients (SFP Neuro-Oncology)NCT06528912 · n/a · 📍 GroningenS1501 Dual Observational and Randomized Cohort Study of Patients With Metastatic HER-2+ Breast Cancer at Risk…NCT03418961 · Phase 3 · 📍 AnchorageBevacizumab Versus Corticosteroids as First-line Treatment in Patients With Symptomatic Cerebral Radiation Ne…NCT06888817 · Phase 3 · 📍 AmsterdamLocal Control, Quality of Life and Toxicities in Adults With Benign or Indolent Brain Tumors Undergoing Proto…NCT03286335 · NA · 📍 BostonCAYA Cancer Prospective Cohort StudyNCT07632014 · n/a · 📍 YerevanDevelopment of Measures to Screen for Financial Hardship in Alzheimer's Disease and DementiaNCT06922188 · n/a · 📍 SeattleNovel Ga68-PSMA PET/CT-tracer to Differentiate Between Radiation Necrosis and Tumor Progression in Brain Meta…NCT07511933 · NA · 📍 Amsterdam Search more trials →
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AI Cure shows public evidence (Open Targets, ClinicalTrials.gov, PubMed, openFDA, DepMap, AlphaFold) with its source, and AI summaries that cite it — not medical advice and not a cure. Treatment decisions belong with your doctor. Research ideas are shared only with approved researchers and labs, who can test them. In an emergency call your local emergency number (112 in India and Europe, 911 in the US). AI Cure Terms of Use · Privacy