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๐Ÿ“ฐ Latest breakthroughs
๐Ÿ—บ๏ธ Disease Atlas ยท Nervous system disorder

neurotoxicity

Toxicity that causes injury to the central or peripheral nervous system or damages its function. This can include stroke, multiple sclerosis, encephalopathy, dementia, Alzheimer's disease, amnesia, dyskinesia, Parkinson's disease, tremor, convulsions and Guillain Barre syndrome.

๐Ÿ”” Follow weekly
๐Ÿงฌ448genes / proteins with evidence
๐Ÿ’Š4drugs and clinical candidates
๐Ÿงช12+recruiting trials worldwide
โœ…1phase 3
๐Ÿ“ˆ2early phase 1
๐Ÿ”ฌ

Understand neurotoxicity

Every other disease ยท Genes, environment and time
๐ŸŽ“ Learn more

What it is

There are more than 600 neurologic diseases. Major types include:

Diseases caused by faulty genes, such as Huntington's disease and muscular dystrophy

Problems with the way the nervous system develops, such as spina bifida

From MedlinePlus: Neurologic Diseases (US National Library of Medicine) โ†—

๐Ÿ”ฌ Every other disease: Most diseases come from a mix of the genes we inherit, the environment and way we live, and the passing of time.

โ“ Why it happens

  • Genes can make a person more or less likely to get a disease.
  • Environment and lifestyle - infections, diet, smoking, pollution, activity - push the risk up or down.
  • Errors build up in the body over the years, which is why many diseases are more common with age.

๐Ÿซ€ What it does to the body

  • Each disease affects the body in its own way; the summary above explains this one.

๐Ÿงฑ Why it is hard to cure

  • The biology is often only partly understood.
  • A medicine has to be both effective and safe, and proving that in clinical trials takes years.

๐Ÿš€ What research is trying now

  • Studying which genes are linked to the disease - AI Cure shows them below, ranked by evidence.
  • Testing whether medicines approved for other diseases could help.

General information about every other disease, reviewed by people; it does not describe any one person. Below: the evidence for neurotoxicity itself.

๐Ÿค–

AI briefing

Where the science on neurotoxicity stands, from the evidence on this page

AI reads the targets, drugs, trials and papers below and writes where the science stands โ€” every claim cited. It is shared with everyone who opens neurotoxicity.

๐ŸŽฏ

Top targets

Genes and proteins ranked by Open Targets evidence (0-1)
GRIN2A glutamate ionotropic receptor NMDA type subunit 2APROTACantibodyothersmall molecule๐ŸงŠ AlphaFold structure โ†— 0.06
GRIN2B glutamate ionotropic receptor NMDA type subunit 2BPROTACantibodyothersmall molecule๐ŸงŠ AlphaFold structure โ†— 0.06
GRIN2D glutamate ionotropic receptor NMDA type subunit 2DPROTACantibodyothersmall molecule๐ŸงŠ AlphaFold structure โ†— 0.06
GRIN2C glutamate ionotropic receptor NMDA type subunit 2CPROTACantibodyothersmall molecule๐ŸงŠ AlphaFold structure โ†— 0.06
GRIN1 glutamate ionotropic receptor NMDA type subunit 1PROTACantibodyothersmall molecule๐ŸงŠ AlphaFold structure โ†— 0.06
GRIN3A glutamate ionotropic receptor NMDA type subunit 3APROTACantibodyothersmall molecule๐ŸงŠ AlphaFold structure โ†— 0.06
GRIN3B glutamate ionotropic receptor NMDA type subunit 3BPROTACantibodyothersmall molecule๐ŸงŠ AlphaFold structure โ†— 0.06
GZMB granzyme BPROTACantibodysmall molecule๐ŸงŠ AlphaFold structure โ†— 0.03
BDNF brain derived neurotrophic factorPROTACantibody๐ŸงŠ AlphaFold structure โ†— 0.02
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alphaPROTACantibodysmall molecule๐ŸงŠ AlphaFold structure โ†— 0.02
WNK1 WNK lysine deficient protein kinase 1PROTACsmall molecule๐ŸงŠ AlphaFold structure โ†— 0.02
SNCA synuclein alphaPROTACantibodysmall molecule๐ŸงŠ AlphaFold structure โ†— 0.02
PARP1 poly(ADP-ribose) polymerase 1PROTACsmall molecule๐ŸงŠ AlphaFold structure โ†— 0.02
NFKB1 nuclear factor kappa B subunit 1PROTACantibodysmall molecule๐ŸงŠ AlphaFold structure โ†— 0.02
TAT tyrosine aminotransferasePROTACsmall molecule๐ŸงŠ AlphaFold structure โ†— 0.02

Green labels: what the target is known to be druggable by. The score combines genetics, somatic mutations, drugs, expression and literature.

๐Ÿ’Š

Drugs and candidates

Every medicine linked to neurotoxicity, by how far it has got
In phase 2 / 3 ยท 1
Monosialotetrahexosylganglioside SodiumPhase 3
Early trials ยท 2
DexamethasoneGlucocorticoid receptor agonistEarly phase 1
SimvastatinHMG-CoA reductase inhibitorEarly phase 1
๐Ÿงช

Recruiting trials

Worldwide, open to new patients now
Nerve Excitability in Cisplatin-Induced Peripheral NeuropathyNCT07095998 ยท NA ยท ๐Ÿ“ BostonIntrathecal Cytarabine, Methotrexate, and Hydrocortisone for the Prevention of High-Grade Chimeric Antigen Reโ€ฆNCT06895473 ยท Phase 2 ยท ๐Ÿ“ PortlandMicrobiome Determinants of Adverse Effects of Stereotactic RadiosurgeryNCT07767981 ยท n/a ยท ๐Ÿ“ ChicagoAtamparib in Patients With Advanced Solid TumorsNCT07374419 ยท Phase 1, Phase 2 ยท ๐Ÿ“ ShanghaiIntrathecal Chemoprophylaxis to Prevent Neurotoxicity Associated With Blinatumomab Therapy for Acute Lymphoblโ€ฆNCT05519579 ยท Phase 2 ยท ๐Ÿ“ AtlantaTacrolimus Associated Tremors in Liver Transplantation: Immediate-Release Versus Extended-Release FormulationsNCT05089604 ยท Phase 4 ยท ๐Ÿ“ Vancouver"The Effect of Memantine on the Prevention and Amelioration of Paclitaxel-induced Toxicity in Breast Cancer Pโ€ฆNCT06679387 ยท Phase 2 ยท ๐Ÿ“ CairoChemotherapy Induced Peripheral Neurotoxicity (CIPN): Why Should we CareNCT04986891 ยท n/a ยท ๐Ÿ“ MonzaExtracellular Vesicles and Chemotherapy-Induced Peripheral NeuropathyNCT07558447 ยท NA ยท ๐Ÿ“ MilanMultimodal Assessment of Cryotherapy for Paclitaxel-Induced NeuropathyNCT07780955 ยท NA ยท ๐Ÿ“ BolzanoA Pilot Study for Pupillary Assessment to Predict CAR-T Related NeurotoxicityNCT06144151 ยท n/a ยท ๐Ÿ“ HoustonInternational CIPN Assessment and Validation StudyNCT04633655 ยท n/a ยท ๐Ÿ“ Birmingham Search more trials โ†’
๐Ÿ›ก๏ธ

AI Cure shows public evidence (Open Targets, ClinicalTrials.gov, PubMed, openFDA, DepMap, AlphaFold) with its source, and AI summaries that cite it โ€” not medical advice and not a cure. Treatment decisions belong with your doctor. Research ideas are shared only with approved researchers and labs, who can test them. In an emergency call your local emergency number (112 in India and Europe, 911 in the US). AI Cure Terms of Use ยท Privacy