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Oral cavity squamous cell carcinoma: the latest breakthroughs

Everything that changed in the last year, from three public sources: phase 3 trials that posted their results, papers in the leading medical and cancer journals, and US drug labels that were updated. Refreshed every week.

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What changed

Written by AI from the evidence below, every point cited

AI reads the results, papers and label updates below and explains what changed and why it matters, citing each source. It is shared with everyone.

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Phase 3 results posted

The large trials that decide new standard treatments · ClinicalTrials.gov
Phase III Xevinapant (Debio 1143) and Radiotherapy in Resected LA SCCHN, High Risk, Cisplatin-ineligible Participants (XRAY VISION)NCT05386550 · results posted 2026-02-19 · EMD Serono Research & Development Institute, Inc. · 166 people · tests Xevinapant, IMRT, Placebo LUX-Head&Neck 3: Afatinib (BIBW2992) Versus Methotrexate for the Treatment of Recurrent and/or Metastatic Head and Neck Squamous Cell Cancer After Platinum Based ChemotherapyNCT01856478 · results posted 2026-01-12 · Boehringer Ingelheim · 340 people · tests Methotrexate, Afatinib
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In the leading journals

NEJM, Lancet, Nature, JCO, Cancer Cell and more · PubMed
Human Development and the Architecture of Everyday Worry: Latent Worry Profiles in the World Risk Poll.Risk Anal 2026 · PMID 42929097 Associations between cognition and functioning: examining the role of mental health in clinically ascertained and population-based samples.BJPsych Open 2026 · PMID 42929084 Eating disorders and exercise therapy: scoping review on outcome measures used in eating disorder and exercise research.BJPsych Open 2026 · PMID 42929080 Disruption of OsMAPKKK24 activation by the Xanthomonas oryzae effector XopY leads to compromised disease resistance in rice.J Integr Plant Biol 2026 · PMID 42929059 The Triple Burden: Tramadol, NSAIDS, and Energy Drinks Among Agricultural Workers in La Gomera, Guatemala: An Anthropological Study.J Agromedicine 2026 · PMID 42929053 Bidirectional Interaction Between Clock Genes and Reactive Oxygen Species Production in Carp and Zebrafish Macrophages.Ann N Y Acad Sci 2026 · PMID 42929052 Enrichment of In Utero Rhythmic Experience Promotes Postnatal Visuospatial Attention.Ann N Y Acad Sci 2026 · PMID 42929049 Hydrostatic Pressure-Mediated Chondrocyte Homeostasis in Osteoarthritis and Cartilage Engineering.Ann N Y Acad Sci 2026 · PMID 42929041 NOR-1 is an upstream regulator of Ca2+ homeostasis and calmodulin kinase II-dependent arrhythmogenesis.Cardiovasc Res 2026 · PMID 42929040 Sphingolipid Dysregulation in Impaired Spermatogenesis: Azoospermic Mouse Model.Int J Fertil Steril 2026 · PMID 42929026 A Novel Endoscopic Suture Anchor (ESA) Device for Full-Thickness Defect Closure: A Comprehensive Ex Vivo and In Vivo Evaluation (With Video…J Dig Dis 2026 · PMID 42928992 Cordycepin Regulates the Nrf2/Hmox1 Signaling Pathway to Inhibit Ferroptosis and Improve AKI-CKD.Cell Biochem Funct 2026 · PMID 42928985
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US drug labels updated

A label changes when a new use, dose or warning is approved · openFDA

No label updates found.

An update is not always a new approval — open the label to see what changed.

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