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A chronic condition characterized by minimal or absent production of insulin by the pancreas.
Diabetes means your blood glucose, also called blood sugar, is too high. With type 1 diabetes, your body makes little or no insulin. Insulin is a hormone from your pancreas that helps glucose move from your body into your cells, where it is used for energy. Your body can make glucose, but it also comes from the food you eat. Without insulin, too much glucose stays in your blood.
Over time, high blood glucose can lead to serious problems with your heart, eyes, kidneys, nerves, gums, and teeth.
If your blood glucose gets very high, you can develop diabetic ketoacidosis (DKA). It happens when your body doesn't have enough insulin to allow glucose into your cells. Instead, your liver breaks down fat for energy, which produces ketones. When ketones build up too quickly, they can reach dangerous levels. DKA is a life-threatening emergency.
From MedlinePlus: Diabetes Type 1 (US National Library of Medicine) ↗
🩸 Diabetes and metabolism: In diabetes the body cannot make enough insulin, or cannot use it well, so sugar (glucose) stays too high in the blood instead of feeding the body's cells.
General information about diabetes and metabolism, reviewed by people; it does not describe any one person. Below: the evidence for type 1 diabetes mellitus itself.
AI reads the targets, drugs, trials and papers below and writes where the science stands — every claim cited. It is shared with everyone who opens type 1 diabetes mellitus.
Green labels: what the target is known to be druggable by. The score combines genetics, somatic mutations, drugs, expression and literature.
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