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Pancreatic ductal adenocarcinoma: the latest breakthroughs

Everything that changed in the last year, from three public sources: phase 3 trials that posted their results, papers in the leading medical and cancer journals, and US drug labels that were updated. Refreshed every week.

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What changed

Written by AI from the evidence below, every point cited

AI reads the results, papers and label updates below and explains what changed and why it matters, citing each source. It is shared with everyone.

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Phase 3 results posted

The large trials that decide new standard treatments · ClinicalTrials.gov
Sandostatin LAR and Axitinib vs Pbo in Pnts With Advanced Well-differentiated Non-pancreatic Neuroendocrine CarcinomasNCT01744249 · results posted 2026-04-28 · Grupo Espanol de Tumores Neuroendocrinos · 256 people · tests Axitinib, Sandostatin LAR, Placebo Efficacy and Safety of 177Lu-edotreotide PRRT in GEP-NET PatientsNCT03049189 · results posted 2026-04-06 · ITM Solucin GmbH · 324 people · tests 177Lu-edotreotide PRRT, Everolimus, Amino-Acid Solution Study of Romiplostim for Chemotherapy-induced Thrombocytopenia in Adult Subjects With Gastrointestinal, Pancreatic, or Colorectal CancerNCT03362177 · results posted 2026-02-11 · Amgen · 165 people · tests Romiplostim, Placebo Effect of Tumor Treating Fields (TTFields, 150 kHz) as Front-Line Treatment of Locally-advanced Pancreatic Adenocarcinoma Concomitant With Gemcitabine and Nab-paclitaxel (PANOVA-3)NCT03377491 · results posted 2026-01-21 · NovoCure Ltd. · 571 people · tests NovoTTF-200T, Gemcitabine, nab paclitaxel
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In the leading journals

NEJM, Lancet, Nature, JCO, Cancer Cell and more · PubMed
Neoadjuvant nivolumab with or without visugromab in muscle-invasive bladder cancer: the phase 2a GDFATHER-NEO trial.Nat Med 2026 · PMID 42926233 Relatlimab plus nivolumab versus nivolumab for advanced melanoma: 5-year survival and biomarker analyses of the phase 3 RELATIVITY-047 tria…Nat Med 2026 · PMID 42926136 Pembrolizumab Plus Chemotherapy for HR+/HER2- PD-L1‒Positive Advanced Breast Cancer: Final Analysis of the Phase 3 KEYNOTE-B49 Study.Ann Oncol 2026 · PMID 42926111 Atirmociclib and fulvestrant for patients with HR+/HER2- advanced/metastatic breast cancer who progressed on a prior cyclin-dependent kinas…Ann Oncol 2026 · PMID 42926110 Adjuvant chemotherapy with cisplatin and gemcitabine compared to standard of care after curative intent resection of cholangiocarcinoma and…Ann Oncol 2026 · PMID 42926109 Overall survival from the phase III postMONARCH trial of abemaciclib plus fulvestrant versus placebo plus fulvestrant for HR+, HER2- advanc…Ann Oncol 2026 · PMID 42926108 A randomized Phase 1 study of telisotuzumab adizutecan (ABBV-400, Temab-A) in combination with bevacizumab versus trifluridine-tipiracil wi…Ann Oncol 2026 · PMID 42926107 Final results of nivolumab plus ipilimumab versus nivolumab or chemotherapy in microsatellite instability-high/mismatch repair-deficient me…Ann Oncol 2026 · PMID 42926106 Optimising late-line treatment administration in metastatic colorectal cancer: an even brighter SUNLIGHT.Lancet 2026 · PMID 42925881 14-day versus 28-day trifluridine-tipiracil plus bevacizumab for refractory metastatic colorectal cancer (PRABITAS): a pragmatic, multicent…Lancet 2026 · PMID 42925880 Q&A: Dan Landau on Somatic Evolution.Cancer Discov 2026 · PMID 42924526 ENZARAD (ANZUP 1303): Phase 3 Trial of Enzalutamide With Androgen Deprivation Therapy and Radiation Therapy in High-Risk Localized or Local…J Clin Oncol 2026 · PMID 42921729

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