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🗺️ Disease Atlas · Endocrine system disorder

malignant pancreatic neoplasm

A malignant neoplasm involving the pancreas.

🔔 Follow weekly
🧬11252genes / proteins with evidence
💊461drugs and clinical candidates
🧪12+recruiting trials worldwide
✅9approved
📈50phase 3
🧬

Understand malignant pancreatic neoplasm

Cancer · Cells that grow out of control
🎓 Learn more

What it is

Smoking

Long-term diabetes

Chronic pancreatitis

From MedlinePlus: Pancreatic Cancer (US National Library of Medicine) ↗

🧬 Cancer: Cancer is a group of diseases in which some of the body's cells grow and divide without control, and can spread to other parts of the body.

❓ Why it happens

  • Changes (mutations) build up in the genes that tell a cell when to grow, divide and die.
  • Most of these changes happen during life: tobacco, too much sun, alcohol, some infections (such as HPV and hepatitis B and C), radiation, obesity and ageing all raise the risk.
  • Some people inherit a faulty gene that raises their risk, such as BRCA1 or BRCA2.

🫀 What it does to the body

  • Cancer cells form a lump (tumour) that can press on or invade nearby organs.
  • They can travel through the blood or lymph to start new tumours elsewhere (metastasis).
  • Blood cancers crowd out healthy blood cells in the bone marrow.

🧱 Why it is hard to cure

  • Every cancer is different, even between two people with the same type - and inside one tumour.
  • Cancer cells keep changing, so they can learn to resist a medicine that worked at first.
  • Cancer cells are the body's own cells, so killing them without harming healthy cells is hard.
  • Many cancers cause no symptoms until they have spread, and a new medicine often takes more than ten years to go from the lab to patients.

🚀 What research is trying now

  • Targeted medicines against the exact gene change in a tumour (for example EGFR, ALK or KRAS).
  • Immunotherapy that helps the immune system recognise cancer, including CAR-T cell therapy.
  • Personalised cancer vaccines built from each tumour's mutations, now in late trials.
  • Blood tests that look for tumour DNA to find cancer earlier, and AI to read scans and slides.

General information about cancer, reviewed by people; it does not describe any one person. Below: the evidence for malignant pancreatic neoplasm itself.

🤖

AI briefing

Where the science on malignant pancreatic neoplasm stands, from the evidence on this page

AI reads the targets, drugs, trials and papers below and writes where the science stands — every claim cited. It is shared with everyone who opens malignant pancreatic neoplasm.

🎯

Top targets

Genes and proteins ranked by Open Targets evidence (0-1)
KRAS KRas proto-oncogene, GTPasePROTACantibodysmall molecule🧊 AlphaFold structure ↗ 0.82
TP53 tumor protein p53PROTACothersmall molecule🧊 AlphaFold structure ↗ 0.80
SMAD4 SMAD family member 4PROTACsmall molecule🧊 AlphaFold structure ↗ 0.80
PALB2 partner and localizer of BRCA2PROTACsmall molecule🧊 AlphaFold structure ↗ 0.79
BRCA2 BRCA2 DNA repair associatedPROTACsmall molecule🧊 AlphaFold structure ↗ 0.76
CDKN2A cyclin dependent kinase inhibitor 2A🧊 AlphaFold structure ↗ 0.74
STK11 serine/threonine kinase 11PROTACsmall molecule🧊 AlphaFold structure ↗ 0.74
RNF43 ring finger protein 43PROTACantibody🧊 AlphaFold structure ↗ 0.71
POLD1 DNA polymerase delta 1, catalytic subunitPROTACsmall molecule🧊 AlphaFold structure ↗ 0.70
ATM ATM serine/threonine kinasePROTACsmall molecule🧊 AlphaFold structure ↗ 0.70
BRCA1 BRCA1 DNA repair associatedPROTACantibodysmall molecule🧊 AlphaFold structure ↗ 0.69
POLE DNA polymerase epsilon, catalytic subunitPROTACantibodysmall molecule🧊 AlphaFold structure ↗ 0.68
ARID1A AT-rich interaction domain 1APROTAC🧊 AlphaFold structure ↗ 0.67
TGFBR2 transforming growth factor beta receptor 2PROTACantibodysmall molecule🧊 AlphaFold structure ↗ 0.65
ACVR1B activin A receptor type 1BPROTACantibodysmall molecule🧊 AlphaFold structure ↗ 0.64

Green labels: what the target is known to be druggable by. The score combines genetics, somatic mutations, drugs, expression and literature.

💊

Drugs and candidates

Every medicine linked to malignant pancreatic neoplasm, by how far it has got
Approved · 9
Anamorelin HydrochlorideGhrelin receptor agonistApproved
BentiromideApproved
FluorouracilThymidylate synthase inhibitorApproved
Folinic AcidApproved
Irinotecan Hydrochloride HydrateApproved
OxaliplatinApproved
Show all 9
StreptozocinApproved
TrimethadioneVoltage-gated T-type calcium channel blockerApproved
Uridine TriacetateApproved
In phase 2 / 3 · 20
AfliberceptVascular endothelial growth factor A inhibitor; Placenta growth factor inhibitorPhase 3
Algenpantucel-LPhase 3
AsparaginasePhase 3
AxitinibVascular endothelial growth factor receptor inhibitorPhase 3
BevacizumabVascular endothelial growth factor A inhibitorPhase 3
CamrelizumabProgrammed cell death protein 1 antagonistPhase 3
Show all 20
CapecitabineThymidylate synthase inhibitorPhase 3
Charcoal, ActivatedPhase 3
ClopidogrelPurinergic receptor P2Y12 antagonistPhase 3
Cpi 613Phase 3
Demplatin PegraglumerPhase 3
DocetaxelTubulin inhibitorPhase 3
ErlotinibEpidermal growth factor receptor erbB1 inhibitorPhase 3
Erlotinib HydrochlorideEpidermal growth factor receptor erbB1 inhibitorPhase 3
FluzoparibPhase 3
Folitixorin CalciumPhase 3
GemcitabineRibonucleoside-diphosphate reductase RR1 inhibitor; DNA polymerase (alpha/delta/epsilon) …Phase 3
Gemcitabine HydrochlorideRibonucleoside-diphosphate reductase RR1 inhibitor; DNA polymerase (alpha/delta/epsilon) …Phase 3
GimeracilDihydropyrimidine dehydrogenase inhibitorPhase 3
GlufosfamidePhase 3
Early trials · 20
2X-121Poly [ADP-ribose] polymerase-1 inhibitor; Poly [ADP-ribose] polymerase 2 inhibitorPhase 1/2
AdavosertibSerine/threonine-protein kinase WEE1 inhibitorPhase 1/2
Aeg-35156Phase 1/2
Aglatimagene BesadenovecPhase 1/2
Ar-20.5Mucin-1 otherPhase 1/2
AroplatinPhase 1/2
Show all 20
Avasopasem ManganesePhase 1/2
AvotaciclibPhase 1/2
Azd-9574Phase 1/2
AzeliragonAdvanced glycosylation end product-specific receptor antagonistPhase 1/2
BelzutifanEndothelial PAS domain-containing protein 1 inhibitorPhase 1/2
BexmarilimabPhase 1/2
Bintrafusp AlfaProgrammed cell death 1 ligand 1 binding agent; Transforming growth factor beta binding a…Phase 1/2
Bms-986148Phase 1/2
CafelkibartPhase 1/2
CamptothecinPhase 1/2
CertepetidePhase 1/2
Cg-200745Phase 1/2
Chembl569766Phase 1/2
CixutumumabInsulin-like growth factor I receptor antagonistPhase 1/2
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AI Cure shows public evidence (Open Targets, ClinicalTrials.gov, PubMed, openFDA, DepMap, AlphaFold) with its source, and AI summaries that cite it — not medical advice and not a cure. Treatment decisions belong with your doctor. Research ideas are shared only with approved researchers and labs, who can test them. In an emergency call your local emergency number (112 in India and Europe, 911 in the US). AI Cure Terms of Use · Privacy