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Glioblastoma: the latest breakthroughs

Everything that changed in the last year, from three public sources: phase 3 trials that posted their results, papers in the leading medical and cancer journals, and US drug labels that were updated. Refreshed every week.

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What changed

Written by AI from the evidence below, every point cited

AI reads the results, papers and label updates below and explains what changed and why it matters, citing each source. It is shared with everyone.

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Phase 3 results posted

The large trials that decide new standard treatments · ClinicalTrials.gov
Tofacitinib in Recurrent GBM PatientsNCT05326464 · results posted 2026-06-29 · University of Texas Southwestern Medical Center · 18 people · tests Tofacitinib 10mg, Temozolomide, Lomustine
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In the leading journals

NEJM, Lancet, Nature, JCO, Cancer Cell and more · PubMed
EGFR-targeted antibody-toxin conjugate in recurrent glioma: a phase 1 trial.Nat Med 2026 · PMID 42888247 Genomic alterations and treatment define spatiotemporal patterns of glioblastoma recurrence.Cancer Discov 2026 · PMID 42820945 Spatial analysis reveals the evolving organization of IDH-mutant glioma.Cancer Cell 2026 · PMID 42735681 Publisher Correction: Adjuvant personalized multivalent neoantigen DNA vaccination for MGMT unmethylated glioblastoma: a phase 1 trial.Nat Cancer 2026 · PMID 42680941 Mitochondrial Complex I at the Crossroads of NK cell Dysfunction in Glioblastoma.Cancer Discov 2026 · PMID 42676102 Galanin impairs tumor immunity in glioblastoma by promoting infiltration and ferroptosis resistance of myeloid-derived suppressor cells.Nat Cancer 2026 · PMID 42642633 Exploring the landscape of targetable alterations in patients with glioblastoma.Nat Rev Clin Oncol 2026 · PMID 42618642 Laser Interstitial Thermal Therapy for Brain Tumors: A Prospective Multicenter Analysis of Patients From the LAANTERN Study.J Clin Oncol 2026 · PMID 42607280 Intracranial delivery of B7-H3-targeting CAR-T cells for recurrent glioblastoma: a phase 1 trial.Nat Med 2026 · PMID 42562965 Corticosteroids in Glioblastoma Management: A Reconsideration of a 65-Year Practice.J Clin Oncol 2026 · PMID 42485601 Anti-LAG-3 with or without anti-PD-1 in recurrent glioblastoma: a phase 1 trial.Nat Med 2026 · PMID 42432293 Stressed bones and glioblastoma.Cancer Cell 2026 · PMID 42425072

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