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Clinical trials test new treatments — sometimes the newest options available for a disease. Find trials that are recruiting now, near you. Open one to see its eligibility rules as simple questions to go through with your doctor.

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30 recruiting trials

for Heart Failure and Reduced Ejection Fraction

Demographic, Clinical, Biological, Treatment Characteristics and Cardiovascular Events of Patients With Heart Failure in Vietnam: a Multicenter Prospective Observational Study NCT06516562n/a1 site📍 Ho Chi Minh City University Medical Center Ho Chi Minh City (UMC) · Tests: Optimal treatment Exercise Capacity Improvement by Conduction System Pacing in heArt Failure patieNts Without Compelling CRT inDication NCT06278844NA1 site📍 Edegem University Hospital, Antwerp · Tests: Conduction system pacing, Right ventricular apical pacing A Research Study to Look at How Well NNC0487-0111 Works Compared to Placebo in People With Heart Failure and Obesity NCT07567001Phase 3838 sites📍 Alexander City📍 Birmingham📍 Fairhope Novo Nordisk A/S · Tests: NNC0487-0111, Placebo Maridebart Cafraglutide in Heart Failure With Preserved or Mildly Reduced Ejection Fraction and Obesity NCT07037459Phase 3657 sites📍 Birmingham📍 Dothan📍 Fairhope Amgen · Tests: Maridebart cafraglutide, Placebo Empagliflozin in Heart Failure with Reduced Ejection Fraction and End Stage Renal Disease NCT06249932Phase 42 sites📍 Hsinchu📍 Taipei National Taiwan University Hospital · Tests: Empagliflozin 25 MG, Placebo Eccentric Muscle Training in Cardiac Rehabilitation NCT07636343NA1 site📍 Edegem University Hospital, Antwerp · Tests: eccentric bike training, eccentric overload training, aerobic treadmill training, aerobic bike training, traditional dy… Propensity-Matched Study of Cardiac Contractility Modulation Therapy in Heart Failure NCT07209098n/a1 site📍 Marlton Impulse Dynamics · Tests: Cardiac Contractility Modulation (CCM) Mechanistic Clinical Trial Comparing the Pharmacokinetics/Pharmacodynamics of Metoprolol in Heart Failure With Reduced Ejection Fraction Patients With Low vs. High Polygenic Score NCT07490067Phase 41 site📍 Ann Arbor University of Michigan · Tests: Metoprolol Succinate, Beta-Blocker Polygenic Score, Illumina Infinium Global Diversity Array with Enhanced Pharmacogeno… The CardioClip Study NCT06241430NA1 site📍 New York Columbia University · Tests: CardioMEMS SHengXIaN-QuYu DEcoction in Heart Failure With Reduced and Mildly Reduced Ejection Fraction NCT05583773Phase 426 sites📍 Beijing📍 Beijing📍 Beijing China-Japan Friendship Hospital · Tests: ShengXian-QuYu Decoction, Placebo Effect of Pre-Hospital ARNI Therapy on Short-Term Outcomes in HFrEF NCT07347925n/a1 site📍 Al Mansurah Future University in Egypt · Tests: Prehospital ARNI use, No prehospital ARNI use Lumacaftor Yields Reversal of Impaired Cerebral Blood Flow in Heart Failure Patients NCT07695090Phase 22 sites📍 Toronto📍 Toronto Qanatpharma AG · Tests: Lumacaftor 200 MG, Placebo A Randomized Placebo-procedure Controlled Trial of the Enhancor System (PULmonary Artery Denervation) to Evaluate Safety and Efficacy in Patients With Combined Pre- and Post-capillary Pulmonary Hypertension Associated With Left Heart Disease NCT07214376NA18 sites📍 Tucson📍 New Haven📍 Weston Pulnovo Medical, Inc. · Tests: Pulmonary Artery Denervation (PADN), Sham procedure control Biomechanical Precision Medicine Registry for Patients With and Without Heart Failure NCT03480633n/a1 site📍 Boston Massachusetts General Hospital Pulmonary Artery Catheterization and Carvedilol Early Initiation in Cardiogenic SHOCK Due to HFrEF NCT06078436NA1 site📍 Seoul Min-Seok Kim · Tests: Pulmonary artery catheter Endocardial Delivery for Myocardial Regeneration Using Allogeneic iPSC-derived Cardiomyocyte Spheroids for HF With Systolic Dysfunction (EMERALD Study) NCT07347197Phase 1, Phase 25 sites📍 Tsukuba📍 Kawasaki📍 Matsumoto Heartseed Inc. · Tests: HS-005 Ketones, SGLT2, HFrEF NCT06229678EARLY Phase 11 site📍 San Antonio The University of Texas Health Science Center at San Antonio · Tests: Empagliflozin 25 MG Oral Tablet, Placebo, Acipimox 250 Mg Oral Capsule Acute and Chronic Effects of Oral Ketones in Subjects With HFrEF and Diabetes NCT06108076EARLY Phase 11 site📍 San Antonio The University of Texas Health Science Center at San Antonio · Tests: Ketone Monoester (KE) AI-Based Monitoring System for Chronic Heart Failure With Advanced Wearable and Mini-Invasive Devices NCT06909682n/a1 site📍 Salerno University of Salerno · Tests: Intervention Group (Device Group - AI-Based Remote Monitoring), Standard Clinical Follow-Up Study to Collect High-Resolution ECG Data and Patient Insights on Heart Failure Care NCT06809686n/a2 sites📍 London📍 London Richmond Research Institute A Study to Learn About the Study Medicine Called PF-07328948 in Adults With Heart Failure (BRANCH-HF) NCT06991257Phase 2150 sites📍 Beverly Hills📍 Lake Forest📍 Santa Maria Pfizer · Tests: Placebo, Low Dose PF-07328948, Medium Dose PF-07328948, High Dose PF-07328948 Comparative Effectiveness of Carvedilol Versus Metoprolol Succinate in Heart Failure Patients With an Implantable Cardioverter Defibrillator NCT06964464Phase 413 sites📍 Scottsdale📍 Rome📍 Shawnee Mission University of Rochester · Tests: Metoprolol Succinate, Carvedilol Exercise Rehabilitation for Cardiorenal Syndrome in HFrEF Patients NCT07167368NA1 site📍 Nantong Haiyan Pan · Tests: Standardized Basic Drug Therapy for HFrEF with Chronic Kidney Dysfunction, Home-based Personalized Exercise Rehabilitat… Swedish Cardiac And Renal Failure Study-1 NCT07029503Phase 21 site📍 Stockholm Karolinska Institutet · Tests: Eplerenone Infusing Needed Iron to Target Insufficiency in Adults Treated for Evidence of Heart Failure NCT07467668NA1 site📍 Pleasanton Kaiser Permanente · Tests: Notification Group, No Notification Group Left vs Left Randomized Clinical Trial NCT05650658NA71 sites📍 Gilbert📍 Tucson📍 Little Rock Baylor College of Medicine · Tests: His/LBBP, BiVP Study on the Efficacy and Safety of HRS-7535 in Patients With Mild Decrease in Ejection Fraction/Preserved Ejection Fraction Heart Failure and Obesity NCT06820099Phase 21 site📍 Beijing Shandong Suncadia Medicine Co., Ltd. · Tests: HRS-7535 tablet, HRS-7535 tablet placebo Conventional Biventricular Versus Left Bundle Branch Pacing on Outcomes in Heart Failure Patients NCT05769036NA1 site📍 Tomsk Tomsk National Research Medical Center of the Russian Acade… · Tests: Implantation of Cardioverter-defibrillator with a Resynchronization Function Using Biventricular Pacing, Implantation o… Developing a Digital Aid to Improve ICD Decisions NCT07084142NA2 sites📍 San Francisco📍 Greenville Stanford University · Tests: Online, patient-facing decision-making aid (app) with personalized risk information., Implantable Cardioverter Defibril… Real-Time Monitoring of Heart Failure Across the Yale New Haven Health System NCT04237701n/a1 site📍 New Haven Yale University
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