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Clinical trials test new treatments — sometimes the newest options available for a disease. Find trials that are recruiting now, near you. Open one to see its eligibility rules as simple questions to go through with your doctor.

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30 recruiting trials

for High-grade Gliomas

Study in Children and Adolescents of 177Lu-DOTATATE (Lutathera®) Combined With the PARP Inhibitor Olaparib for the Treatment of Recurrent or Relapsed Solid Tumours Expressing Somatostatin Receptor (SSTR) (LuPARPed). NCT06607692Phase 1, Phase 21 site📍 Boadilla del Monte Fundación de investigación HM · Tests: Olaparib; 177Lu-DOTATATE Locoregional Administration of Genetically Engineered Cells (EGFR/IL13Rα2 Pool-CAR T Cells) for the Treatment of Recurrent or Progressive High-Grade Gliomas NCT07544992Phase 11 site📍 Duarte City of Hope Medical Center · Tests: Autologous Anti-EGFR/Anti-IL13Ralpha2 CAR T-cells, Biopsy Procedure, Biospecimen Collection, Echocardiography Test, FDG… Intracranial Genetically Modified Immune Cells (TGFβR2KO/IL13Rα2 CAR T-Cells) for the Treatment of Recurrent or Progressive Glioblastoma or Grade 3 or 4 IDH-Mutant Astrocytoma NCT06815029Phase 11 site📍 Duarte City of Hope Medical Center · Tests: Biospecimen Collection, Chimeric Antigen Receptor T-Cell Therapy, Echocardiography, Fludeoxyglucose F-18, Intracranial … Injection of Active Allogeneic Natural Killer Cells in Patients With Gliomas NCT06687681Phase 21 site📍 Tehran Marzieh Ebrahimi · Tests: NK cell therapy Multiple Intracerebral Doses of Neural Stem Cell-Based Virotherapy (NSC-CRAd-S-pk7) for the Treatment of Recurrent High-Grade Gliomas NCT05139056Phase 14 sites📍 Duarte📍 Stanford📍 Chicago City of Hope Medical Center · Tests: Neural Stem Cells-expressing CRAd-S-pk7, Resection Window Trial of Fluorescently Labeled Nivolumab-IRDye800 (Nivo800) in High Grade Glioma (HGG) NCT07210632EARLY Phase 11 site📍 Nashville Eben Rosenthal · Tests: Nivolumab, Nivolumab-IRDye800 Spectroscopic MRI Guided Proton Therapy in Assessing Metabolic Change in Pediatric Patients With Brain Tumors NCT04908709NA3 sites📍 Atlanta📍 Atlanta📍 Atlanta Emory University · Tests: Magnetic Resonance Spectroscopic Imaging, Proton Therapy Phase 2 Trial of G207 + 5 Gy Radiation for Children With High-Grade Gliomas NCT07649070Phase 21 site📍 Houston M.D. Anderson Cancer Center · Tests: G207 Retifanlimab With or Without Difluoromethylornithine for the Treatment of Progressive High Grade Gliomas NCT07468136Phase 1, Phase 21 site📍 Rochester Mayo Clinic · Tests: Biospecimen Collection, Eflornithine, Lumbar Puncture, Magnetic Resonance Imaging, Retifanlimab Atovaquone Combined With Radiation in Children With Malignant Brain Tumors NCT06624371Phase 12 sites📍 Atlanta📍 Atlanta Emory University · Tests: Atovaquone, Radiation Therapy Dabrafenib and/or Trametinib Rollover Study NCT03340506Phase 438 sites📍 Scottsdale📍 Bethesda📍 Columbus Novartis Pharmaceuticals · Tests: dabrafenib, trametinib Focused Ultrasound Blood-Brain Barrier Disruption for the Treatment of High-Grade Glioma in Patients Undergoing Standard Chemotherapy NCT07179328Phase 11 site📍 Toronto Sunnybrook Health Sciences Centre · Tests: Focused Ultrasound Next Generation Dome Helmet, Definity® Vial for (Perflutren Lipid Microsphere) Injectable Suspension A Ketogenic Diet as a Complementary Treatment on Patients With High-grade Gliomas and Brain Metastases NCT05564949NA2 sites📍 Chaïdári📍 Athens Attikon Hospital · Tests: CKD Metabolomics and Transcriptomics of Low- and High-Grade Gliomas NCT07832734n/a1 site📍 Milan I.R.C.C.S Ospedale Galeazzi-Sant'Ambrogio ABY-029 Glioma Trial NCT07063693Phase 11 site📍 Lebanon Dartmouth-Hitchcock Medical Center · Tests: ABY-029 Fluorescence Enhanced Stereotactic Surgery (FESS) NCT07286903n/a1 site📍 Milan Fondazione I.R.C.C.S. Istituto Neurologico Carlo Besta The PALSUR-study: Palliative Care Versus Surgery in High-grade Glioma Patients (ENCRAM 2203) NCT06146738n/a8 sites📍 San Francisco📍 Boston📍 Leuven Jasper Gerritsen · Tests: Palliative Care, Tumor biopsy, Tumor resection Bevacizumab Neoadjuvant Therapy for New High-grade Gliomas in the Brain NCT06747728NA1 site📍 Zhengzhou The First Affiliated Hospital of Zhengzhou University · Tests: Bevacizumab Surgical Suction Aspirates Fluorescence Measurement NCT06736470n/a1 site📍 Kuopio Kuopio University Hospital NgFUS NIVO: NeuroNavigation-Guided Focused Ultrasound With Nivolumab in Relapsed and Progressive DMG and Other High Grade Brain Tumors NCT07664176Phase 11 site📍 Washington D.C. Children's National Research Institute · Tests: NeuroNavigation-Guided Focused Ultrasound (NgFUS), Lumason, Nivolumab Novel Indenoisoquinolone CMYC/TOPOISOMERASE 1 Inhibitor (LMP744) in Recurrent Glioblastoma NCT07416188Phase 1, Phase 21 site📍 Bethesda National Institute of Neurological Disorders and Stroke (NI… · Tests: LMP744, Conventional Surgery or Biopsy Intratumoral Extracellular Metabolic Impact of DFMO and AMXT 1501 in Patients With Diffuse or High Grade Glioma NCT05717153EARLY Phase 11 site📍 Rochester Mayo Clinic · Tests: Biospecimen Collection, Computed Tomography, Eflornithine, Magnetic Resonance Imaging, Polyamine Transport Inhibitor AM… MAPK Inhibition Combined With Anti-PD1 Therapy for BRAF-altered Pediatric Gliomas NCT06712875Phase 1, Phase 23 sites📍 Washington D.C.📍 Chicago📍 New York Ann & Robert H Lurie Children's Hospital of Chicago · Tests: Trametinib and Nivolumab, Dabrafenib, trametinib, nivolumab DB107-RRV, DB107-FC, and Radiation Therapy With or Without Temozolomide (TMZ) for High Grade Glioma NCT06504381Phase 1, Phase 25 sites📍 Los Angeles📍 San Diego📍 San Francisco University of California, San Francisco · Tests: DB107-RRV, DB107-FC, Radiation Therapy (RT), Temozolomide, Magnetic Resonance Imaging (MRI) Serial Advanced Magnetic Resonance Imaging Scan for Guidance of Personalized Adaptive Radiotherapy for High Grade Glioma NCT04771806n/a1 site📍 Houston M.D. Anderson Cancer Center · Tests: Magnetic Resonance Imaging, Neurocognitive Assessment, Quality-of-Life Assessment, Questionnaire Administration Phase 1 Study of Locoregional Injections of Ex Vivo Expanded Natural Killer Cells NCT04254419Phase 11 site📍 Columbus Nationwide Children's Hospital · Tests: NK cells Concurrent Fluorescence and Sonographically Guided Eradication of High-grade Gliomas and Metastases NCT05474573NA1 site📍 Moscow Sklifosovsky Institute of Emergency Care · Tests: Combined ultrasound and fluorescence-guided brain tumor resection, Fluorescence-guided brain tumor resection A Study of Temodar With Abexinostat (PCI-24781) for Patients With Recurrent Glioma NCT05698524Phase 11 site📍 Omaha University of Nebraska · Tests: PCI 24781, Temozolomide Study of Letrozole in Recurrent Gliomas NCT03122197EARLY Phase 11 site📍 Cincinnati University of Cincinnati · Tests: Letrozole Oral Tablet, Temozolomide CD200AR-L and Allogeneic Tumor Lysate Vaccine Immunotherapy for Recurrent HGG and Newly Diagnosed DMG/DIPG in Children and Young Adults NCT06305910Phase 11 site📍 Minneapolis OX2 Therapeutics · Tests: Treatment with CD200AR-L
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