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Trial Match

Clinical trials test new treatments โ€” sometimes the newest options available for a disease. Find trials that are recruiting now, near you. Open one to see its eligibility rules as simple questions to go through with your doctor.

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๐ŸŽฏ Match trials to me

30 recruiting trials

for KRAS NP_004976.2:p.G12D

A Phase 2 Study of VS-7375 in Patients With KRAS G12D-Mutated Non-Small Cell Lung Cancer NCT07659782Phase 224 sites๐Ÿ“ Scottsdale๐Ÿ“ Los Angeles๐Ÿ“ Los Angeles Verastem, Inc. ยท Tests: VS-7375 A Study to Evaluate the Effectiveness and Safety of Setidegrasib, Given With Either mFOLFIRINOX or NALIRIFOX Chemotherapies, in People With Pancreatic Cancer NCT07409272Phase 379 sites๐Ÿ“ Tucson๐Ÿ“ Fort Smith๐Ÿ“ Fullerton Astellas Pharma Global Development, Inc. ยท Tests: Setidegrasib, Oxaliplatin, Leucovorin, Irinotecan, fluorouracil Study of Zoldonrasib (RMC-9805) Plus Daraxonrasib (RMC-6236) Versus Gemcitabine and Nab-Paclitaxel as First-Line Treatment in Metastatic KRAS G12D-Mutated Pancreatic Adenocarcinoma NCT07805954Phase 35 sites๐Ÿ“ Phoenix๐Ÿ“ Scottsdale๐Ÿ“ Jacksonville Revolution Medicines, Inc. ยท Tests: daraxonrasib, gemcitabine, nab-paclitaxel, zoldonrasib HRS 4642 Injection Combined With AG Versus Placebo Combined With AG Therapy in First-Line Advanced or Metastatic Pancreatic Cancer NCT07232875Phase 31 site๐Ÿ“ Shanghai Jiangsu HengRui Medicine Co., Ltd. ยท Tests: HRS-4642 + AG, HRS-4642 placebo + AG A Phase 2 Study of VS-7375 in Patients With KRAS G12D-Mutated Pancreatic Cancer NCT07644559Phase 238 sites๐Ÿ“ Los Angeles๐Ÿ“ Los Angeles๐Ÿ“ Los Angeles Verastem, Inc. ยท Tests: VS-7375, cetuximab (or panitumumab if ฮฑ-gal IgE+ or cetuximab reaction) A Study of PT0253 in Participants With KRAS G12D Mutated Advanced Solid Tumors NCT06797336Phase 115 sites๐Ÿ“ Los Angeles๐Ÿ“ Boston๐Ÿ“ Grand Rapids PAQ Therapeutics, Inc. ยท Tests: PT0253, Chemotherapy Combination 1, Chemotherapy Combination 2, Chemotherapy Combination 3, Cetuximab Study of RMC-9805 in Participants With KRAS G12D-Mutant Solid Tumors NCT06040541Phase 117 sites๐Ÿ“ Sacramento๐Ÿ“ New Haven๐Ÿ“ Sarasota Revolution Medicines, Inc. ยท Tests: RMC-9805, RMC-6236 A Phase I/II Study of ABSK141 in Patients With Advanced Solid Tumors ( ABSK141-101 ) NCT07417189Phase 1, Phase 21 site๐Ÿ“ Shanghai Abbisko Therapeutics Co, Ltd ยท Tests: ABSK141-400mg, ABSK141-Recommended Dose for Expansion (RDE), ABSK141-800mg, ABSK141-1200mg, ABSK141-Recommended Phase 2โ€ฆ iExosomes in Treating Participants With Metastatic Pancreas Cancer With KrasG12D Mutation NCT03608631Phase 1, Phase 21 site๐Ÿ“ Houston M.D. Anderson Cancer Center ยท Tests: Mesenchymal Stromal Cells-derived Exosomes with KRAS G12D siRNA Phase III Study to Compare GFH375 and Chemotherapy in Patients With KRAS G12D-Mutant Metastatic Pancreatic Cancer NCT07262567Phase 31 site๐Ÿ“ Beijing Genfleet Therapeutics (Shanghai) Inc. ยท Tests: GFH375, Chemotherapy RE002 T Cell Injection for the Treatment of KRAS G12D Mutated Solid Tumors NCT06546150Phase 11 site๐Ÿ“ Zhengzhou Henan Cancer Hospital ยท Tests: RE002 T cell A Study to Find a Suitable Dose of ASP5834 in Adults With Solid Tumors NCT07094204Phase 120 sites๐Ÿ“ Santa Monica๐Ÿ“ Atlanta๐Ÿ“ Jefferson Astellas Pharma Inc ยท Tests: ASP5834, panitumumab A First-in-Human Trial of BLU-924 (SAR449336) in Advanced Solid Tumors Harboring KRAS Mutations NCT07629960Phase 1, Phase 216 sites๐Ÿ“ Sarasota๐Ÿ“ Tampa๐Ÿ“ Baton Rouge Blueprint Medicines Corporation ยท Tests: BLU-924 HRS-4642 With Nimotuzumab and Chemotherapy for First-line Treatment of Advanced Pancreatic Cancer Patients NCT06770452Phase 22 sites๐Ÿ“ Hangzhou๐Ÿ“ Hangzhou Zhejiang University ยท Tests: HRS-4642, Nimotuzumab, gemcitabine + nab-paclitaxel A Phase II Study of GFH375 Combined With GFS202A or GFH276 Versus GFH375 in Patients With Previously Treated Locally Advanced Unresectable or Metastatic Pancreatic Cancer Harboring KRAS G12D Mutation NCT07784374Phase 21 site๐Ÿ“ Shanghai Genfleet Therapeutics (Shanghai) Inc. ยท Tests: GFH375, GFH276, GFS202A Phase 1/2 Trial of S241656 in Selected RAS/MAPK Mutation- Positive Malignancies NCT05786924Phase 1, Phase 249 sites๐Ÿ“ Gilbert๐Ÿ“ Los Angeles๐Ÿ“ Los Angeles Institut de Recherches Internationales Servier ยท Tests: S241656, FOLFOX6/FOLFOX7, FOLFIRI, Cetuximab, Panitumumab A Study of ASP3082 in Adults With Advanced Solid Tumors NCT05382559Phase 168 sites๐Ÿ“ Duarte๐Ÿ“ Santa Monica๐Ÿ“ Denver Astellas Pharma Inc ยท Tests: Setidegrasib, Cetuximab, Leucovorin, Oxaliplatin, Fluorouracil A Study to Evaluate INCB161734 in Participants With Advanced or Metastatic Solid Tumors With KRAS G12D Mutation NCT06179160Phase 134 sites๐Ÿ“ Phoenix๐Ÿ“ Palo Alto๐Ÿ“ Santa Monica Incyte Corporation ยท Tests: INCB161734, Cetuximab, Retifanlimab, GEMNabP, mFOLFIRINOX A Study of HRS-4642 Monotherapy or in Combination With Adebrelimab in the Treatment of Advanced Biliary Tract Tumors. NCT06620848Phase 21 site๐Ÿ“ Shanghai Shanghai Zhongshan Hospital ยท Tests: HRS-4642 monotherapy, HRS-4642 and adebrelimab combination therapy Study of Zoldonrasib + Chemo of Investigator's Choice vs Placebo + Chemo of Investigator's Choice as First-line Treatment in Metastatic KRAS G12D-mutated Pancreatic Adenocarcinoma ( RASolute 305 ) NCT07621718Phase 319 sites๐Ÿ“ Phoenix๐Ÿ“ Tucson๐Ÿ“ New Haven Revolution Medicines, Inc. ยท Tests: Zoldonrasib, Placebo, Oxaliplatin, Leucovorin (Calcium Folinate), 5-Fluorouracil A Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Preliminary Antitumor Activity of INV-8989 in Patients With Advanced Solid Tumors Harboring KRAS G12D Mutations NCT07610798Phase 1, Phase 21 site๐Ÿ“ Guangzhou Shenzhen Ionova Life Sciences Co., Ltd. ยท Tests: INV-8989 A Study to Learn More About How Safe BAY 3771249 is and How Well it Works in People With Advanced or Metastatic Colorectal Cancer That Has a KRAS G12D Mutation NCT07535112Phase 121 sites๐Ÿ“ Phoenix๐Ÿ“ Duarte๐Ÿ“ San Diego Bayer ยท Tests: BAY 3771249, Cetuximab Study of JAB-23E73 in Combination With Chemotherapy in Participants With Metastatic PDAC Harboring KRAS Gene Alterations NCT07640295Phase 1, Phase 213 sites๐Ÿ“ Beijing๐Ÿ“ Hangzhou๐Ÿ“ Beijing Jacobio Pharmaceuticals Co., Ltd. ยท Tests: JAB-23E73 tablet๏ผŒnab-paclitaxel๏ผŒgemcitabine A Study to Evaluate Chemotherapy With or Without INCB161734 in Previously Untreated, KRAS G12D-Mutated Metastatic Pancreatic Ductal Adenocarcinoma NCT07522073Phase 3228 sites๐Ÿ“ Birmingham๐Ÿ“ Anchorage๐Ÿ“ Chandler Incyte Corporation ยท Tests: INCB161734, Placebo, Investigator's choice of chemotherapy A Study of TSN1611 Treating Patients With Advanced Solid Tumors Harboring KRAS G12D Mutation NCT06385925Phase 1, Phase 219 sites๐Ÿ“ Houston๐Ÿ“ San Antonio๐Ÿ“ Fairfax Tyligand Pharmaceuticals (Suzhou) Limited ยท Tests: TSN1611, TSN1611, TSN1611, TSN1611 JAB-23E73 in Adult Participants With Advanced Solid Tumors With KRAS Alteration NCT06973564Phase 1, Phase 24 sites๐Ÿ“ Rochester๐Ÿ“ St Louis๐Ÿ“ Cleveland Jacobio Pharmaceuticals Co., Ltd. ยท Tests: JAB-23E73, Cetuximab A Study to Evaluate GFH375 Versus Docetaxel in Participants With Non-Small Cell Lung Cancer With KRAS G12D Mutation NCT07668752Phase 31 site๐Ÿ“ Shanghai Genfleet Therapeutics (Shanghai) Inc. ยท Tests: GFH375, Docetaxel A Phase II Study of HRS-4642 Combined With AG (Nab-paclitaxel and Gemcitabine) as Conversion Therapy for Locally Advanced Pancreatic Cancer NCT07438106Phase 21 site๐Ÿ“ Nanjing The First Affiliated Hospital with Nanjing Medical Universiโ€ฆ ยท Tests: HRS-4642 Injection QTX3034 in Patients With KRAS G12D Mutation NCT06227377Phase 114 sites๐Ÿ“ Los Angeles๐Ÿ“ Denver๐Ÿ“ New Haven Quanta Therapeutics ยท Tests: QTX3034, Cetuximab Phase I Study of HRS-6093 in Participants With Advanced Solid Tumors Harboring KRAS G12D Mutations NCT07134998Phase 12 sites๐Ÿ“ Shanghai๐Ÿ“ Chengdu Jiangsu HengRui Medicine Co., Ltd. ยท Tests: HRS-6093
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