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Trial Match

Clinical trials test new treatments โ€” sometimes the newest options available for a disease. Find trials that are recruiting now, near you. Open one to see its eligibility rules as simple questions to go through with your doctor.

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๐ŸŽฏ Match trials to me

30 recruiting trials

for KRAS P.G12C

Study of RAS(ON) Inhibitors in Patients With Advanced RAS-mutated NSCLC NCT06162221Phase 1, Phase 298 sites๐Ÿ“ Gilbert๐Ÿ“ Duarte๐Ÿ“ Irvine Revolution Medicines, Inc. ยท Tests: RMC-6291, RMC-6236, Pembrolizumab, Cisplatin, Carboplatin Sotorasib in Combination With Trastuzumab Deruxtecan for the Treatment of Locally Advanced and Metastatic Non-small Cell Lung Cancer With a KRAS G12C Mutation NCT07012031Phase 1, Phase 29 sites๐Ÿ“ Sacramento๐Ÿ“ Tampa๐Ÿ“ Tampa National Cancer Institute (NCI) ยท Tests: Biopsy Procedure, Biospecimen Collection, Computed Tomography, Echocardiography Test, Magnetic Resonance Imaging KO-2806 Monotherapy and Combination Therapies in Advanced Solid Tumors NCT06026410Phase 138 sites๐Ÿ“ Phoenix๐Ÿ“ Tucson๐Ÿ“ Los Angeles Kura Oncology, Inc. ยท Tests: Darlifarnib, Cabozantinib, Adagrasib A Study of Calderasib (MK-1084) Plus Pembrolizumab (MK-3475) in Participants With KRAS G12C Mutant Non-small Cell Lung Cancer (NSCLC) With Programmed Cell Death Ligand 1 (PD-L1) Tumor Proportion Score (TPS) โ‰ฅ50% (MK-1084-004/KANDLELIT-004) NCT06345729Phase 3246 sites๐Ÿ“ Bakersfield๐Ÿ“ Beverly Hills๐Ÿ“ Stamford Merck Sharp & Dohme LLC ยท Tests: Calderasib, Placebo, Pembrolizumab A Study Evaluating Sotorasib Platinum Doublet Combination Versus Pembrolizumab Platinum Doublet Combination as a Front-Line Therapy in Participants With Stage IV or Advanced Stage IIIB/C Nonsquamous Non-Small Cell Lung Cancers (CodeBreaK 202) NCT05920356Phase 3424 sites๐Ÿ“ Santa Barbara๐Ÿ“ Newark๐Ÿ“ Coral Springs Amgen ยท Tests: Sotorasib, Pembrolizumab Sotorasib in Previously Treated Locally Advanced or Metastatic NSCLC Subjects With Mutated KRAS p.G12C NCT05631249Phase 25 sites๐Ÿ“ Lyon๐Ÿ“ Marseille๐Ÿ“ Paris Gustave Roussy, Cancer Campus, Grand Paris ยท Tests: Sotorasib 120Mg Tab Study of Sotorasib, Panitumumab and FOLFIRI Versus FOLFIRI With or Without Bevacizumab-awwb in Treatment-naรฏve Participants With Metastatic Colorectal Cancer With KRAS p.G12C Mutation NCT06252649Phase 3291 sites๐Ÿ“ Chandler๐Ÿ“ Fullerton๐Ÿ“ Long Beach Amgen ยท Tests: FOLFIRI Regimen, Sotorasib, Panitumumab, Bevacizumab-awwb D-1553 Tablet Versus Docetaxel Injection for KRAS G12C Mutation-positive Locally Advanced or Metastatic Non-small Cell Lung Cancer After Prior Standard Therapy Failure NCT06300177Phase 386 sites๐Ÿ“ Hefei๐Ÿ“ Beijing๐Ÿ“ Beijing Chia Tai Tianqing Pharmaceutical Group Co., Ltd. ยท Tests: D-1553 Tablet, Docetaxel injection Study of Olomorasib (LY3537982) in Combination With Standard of Care in Participants With Resected or Unresectable KRAS G12C-mutant Non-Small Cell Lung Cancer NCT06890598Phase 3366 sites๐Ÿ“ Huntsville๐Ÿ“ Mobile๐Ÿ“ Phoenix Eli Lilly and Company ยท Tests: Olomorasib, Pembrolizumab, Durvalumab, Placebo Neoadjuvant Treatment of Fulzerasib Plus Cetuximab N01 in KRAS G12C Mutated Locally Advanced Colorectal Cancer With or Without Resectable Metastases NCT07581912Phase 21 site๐Ÿ“ Hangzhou Zhejiang University ยท Tests: fulzerasib; cetuximab N01 JAB-21822 Combined With JAB-3312 Compared SOC in the First Line for Treatment of Advanced Non-small Cell Lung Cancer With KRAS p.G12C Mutation NCT06416410Phase 337 sites๐Ÿ“ Hefei๐Ÿ“ Beijing๐Ÿ“ Beijing Allist Pharmaceuticals, Inc. ยท Tests: JAB-21822, Tislelizumab, JAB-3312, Pemetrexed, Carboplatin A Study of JAB-21822 in Advanced or Metastatic NSCLC With KRAS p.G12C and STK11 Co-mutation and Wild-type KEAP1 NCT05276726Phase 1, Phase 221 sites๐Ÿ“ Beijing๐Ÿ“ Beijing๐Ÿ“ Beijing Allist Pharmaceuticals, Inc. ยท Tests: JAB 21822 A Phase I Study of BAY3498264 Given Together With Sotorasib in Participants Who Have Advanced Solid Cancers With Specific Genetic Changes Called KRASG12C Mutation NCT06659341Phase 111 sites๐Ÿ“ Albury๐Ÿ“ Macquarie Park๐Ÿ“ Frankston Bayer ยท Tests: BAY3498264 IBI351 Plus Cetuximab ฮฒ in Untreated Advanced Non-small Cell Lung Cancer With KRAS G12C Mutation NCT07198841Phase 27 sites๐Ÿ“ Guangzhou๐Ÿ“ Beijing๐Ÿ“ Foshan Guangdong Association of Clinical Trials ยท Tests: IBI351 combined with cetuximab ฮฒ A Study of D3S-001 Monotherapy or Combination Therapy in Subjects With Advanced Solid Tumors With a KRAS p.G12C Mutation NCT05410145Phase 1, Phase 252 sites๐Ÿ“ Orange๐Ÿ“ Palo Alto๐Ÿ“ Denver D3 Bio (Wuxi) Co., Ltd ยท Tests: D3S-001, Pembrolizumab, Cisplatin, Carboplatin, Pemetrexed A Phase Ib Study of JMKX001899 in Combination With Other Therapies in Advanced NSCLC Harboring KRAS G12C Mutation NCT06946927Phase 11 site๐Ÿ“ Guangzhou Jemincare ยท Tests: JMKX001899, IN10018, Chemotherapy: Pemetrexed, Carboplatin A Study of Calderasib (MK-1084) in KRAS Mutant Advanced Solid Tumors (MK-1084-001) NCT05067283Phase 175 sites๐Ÿ“ Tampa๐Ÿ“ Grand Rapids๐Ÿ“ Hackensack Merck Sharp & Dohme LLC ยท Tests: Calderasib, Pembrolizumab, carboplatin, pemetrexed, cetuximab A Clinical Study of Calderasib (MK-1084) and Other Treatments for Participants With Non-Small Cell Lung Cancer (MK-1084-007/KANDLELIT-007) NCT07190248Phase 3221 sites๐Ÿ“ Birmingham๐Ÿ“ Farmington๐Ÿ“ Stamford Merck Sharp & Dohme LLC ยท Tests: Calderasib, Pembrolizumab (+) Berahyaluronidase alfa, Pemetrexed, Cisplatin, Carboplatin A Study to Find a Suitable Dose of ASP5834 in Adults With Solid Tumors NCT07094204Phase 120 sites๐Ÿ“ Santa Monica๐Ÿ“ Atlanta๐Ÿ“ Jefferson Astellas Pharma Inc ยท Tests: ASP5834, panitumumab A Study of Adagrasib Plus Pembrolizumab Plus Chemotherapy vs. Placebo Plus Pembrolizumab Plus Chemotherapy in Participants With Previously Untreated Non-squamous Non-small Cell Lung Cancer With KRAS G12C Mutation (KRYSTAL-4) NCT06875310Phase 3351 sites๐Ÿ“ Birmingham๐Ÿ“ Springdale๐Ÿ“ Fullerton Mirati Therapeutics Inc. ยท Tests: Adagrasib, Pembrolizumab, Carboplatin, Pemetrexed, Placebo A First-in-Human Trial of BLU-924 (SAR449336) in Advanced Solid Tumors Harboring KRAS Mutations NCT07629960Phase 1, Phase 216 sites๐Ÿ“ Sarasota๐Ÿ“ Tampa๐Ÿ“ Baton Rouge Blueprint Medicines Corporation ยท Tests: BLU-924 A Multicenter Phase 1b/2 Study of Adagrasib, Cetuximab, and Cemiplimab for Metastatic Colorectal Cancer Harboring KRAS G12C Mutations NCT06412198Phase 1, Phase 22 sites๐Ÿ“ Boston๐Ÿ“ Houston M.D. Anderson Cancer Center ยท Tests: Cetuximab, Cemiplimab, Adagrasib A Clinical Study of Calderasib (MK-1084) in People With Advanced Solid Tumors (MK-1084-014) NCT07209111Phase 272 sites๐Ÿ“ Baltimore๐Ÿ“ Grand Rapids๐Ÿ“ Las Vegas Merck Sharp & Dohme LLC ยท Tests: Calderasib, Cetuximab Carfilzomib in Combination With Sotorasib for the Treatment of Patients With KRAS G12C Mutated Advanced or Metastatic Non-small Cell Lung Cancer NCT06249282Phase 12 sites๐Ÿ“ Duarte๐Ÿ“ Irvine City of Hope Medical Center ยท Tests: Biopsy, Biospecimen Collection, Carfilzomib, Computed Tomography, Echocardiography DHF-20-1839-2: Clinical Performance Study Protocol for Therascreenยฎ KRAS RGQ PCR Kit NCT06645236NA1 site๐Ÿ“ Manchester QIAGEN Gaithersburg, Inc ยท Tests: therascreenยฎ KRAS RGQ PCR Kit A Phase 2 Clinical Study of Combination Therapy With ABSK043 and Glecirasib NCT07164170Phase 217 sites๐Ÿ“ Hefei๐Ÿ“ Beijing๐Ÿ“ Beijing Abbisko Therapeutics Co, Ltd ยท Tests: ABSK043 in combination with Glecirasib A Clinical Trial of Calderasib (MK-1084) and Durvalumab in People With Non-Small Cell Lung Cancer (MK-1084-015/KANDLELIT-015) NCT07554339Phase 3103 sites๐Ÿ“ Savannah๐Ÿ“ Lisle๐Ÿ“ Lincoln Merck Sharp & Dohme LLC ยท Tests: Calderasib, Durvalumab, Placebo to MK-1084 Phase 1/2 Trial of S241656 in Selected RAS/MAPK Mutation- Positive Malignancies NCT05786924Phase 1, Phase 249 sites๐Ÿ“ Gilbert๐Ÿ“ Los Angeles๐Ÿ“ Los Angeles Institut de Recherches Internationales Servier ยท Tests: S241656, FOLFOX6/FOLFOX7, FOLFIRI, Cetuximab, Panitumumab Study of JAB-23E73 in Combination With Chemotherapy in Participants With Metastatic PDAC Harboring KRAS Gene Alterations NCT07640295Phase 1, Phase 213 sites๐Ÿ“ Beijing๐Ÿ“ Hangzhou๐Ÿ“ Beijing Jacobio Pharmaceuticals Co., Ltd. ยท Tests: JAB-23E73 tablet๏ผŒnab-paclitaxel๏ผŒgemcitabine KEYMAKER-U01 Substudy 01J: A Study of Pembrolizumab Plus MK-1084 in Participants With Non-Small Cell Lung Cancer (NSCLC) With Kirsten Rat Sarcoma Viral Oncogene Homolog (KRAS) G12C Mutations (MK-3475-01J/KEYMAKER-U01J) NCT07252739Phase 239 sites๐Ÿ“ Clermont๐Ÿ“ Fargo๐Ÿ“ Sioux Falls Merck Sharp & Dohme LLC ยท Tests: MK-1084, Pembrolizumab, Cetuximab, Sacituzumab tirumotecan (sac-TMT), Rescue medication
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