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Trial Match

Clinical trials test new treatments — sometimes the newest options available for a disease. Find trials that are recruiting now, near you. Open one to see its eligibility rules as simple questions to go through with your doctor.

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23 recruiting trials

for Primary Progressive Multiple Sclerosis

Neurodegenerative Diseases Progression Markers (MARKERS-NDD) NCT06596746n/a1 site📍 Cassino Casa di Cura San Raffaele Cassino · Tests: Observation A Study of Anti-CD19 Chimeric Antigen Receptor T-Cell ( CAR-T) Therapy in Subjects With Non-relapsing and Progressive Forms of Multiple Sclerosis NCT06138132Phase 11 site📍 Palo Alto Stanford University · Tests: KYV-101 anti-CD19 CAR-T cell therapy, Standard lymphodepletion regimen Home Based Functional Balance Intervention for Multiple Sclerosis NCT07355387NA1 site📍 Chicago University of Illinois at Chicago · Tests: Multicomponent balance intervention consisting of four components including dual-tasking, functional strength, vestibul… Treatment of Participants With Primary or Secondary Progressive Multiple Sclerosis NCT07477639Phase 1, Phase 28 sites📍 La Jolla📍 Kansas City📍 Rochester Tr1X, Inc. · Tests: TRX319, Bendamustine A Study of Ocrelizumab Administered Subcutaneously in Participants With Multiple Sclerosis Who Switch From an Approved Anti-CD20 Therapy NCT07609719Phase 45 sites📍 Scottsdale📍 Maitland📍 Atlanta Genentech, Inc. · Tests: OCR SC Phase 1 Study of HBI0101 CAR-T in Refractory B-Cell Autoimmune Diseases NCT07085676Phase 11 site📍 Jerusalem Polina Stepensky · Tests: HBI0101 CART The Swedish BioFINDER 2 Study NCT03174938NA2 sites📍 Ängelholm📍 Malmö Skane University Hospital · Tests: Flutemetamol F18 Injection, [18F]-RO6958948, Elecsys (Roche) Abeta42, Ttau and Ptau, Lumipulse (Fujirebio) Abeta42, Tta… Cognitive Performance, Sleep Disturbances and Fatigue in Multiple Sclerosis NCT07426991n/a2 sites📍 Düsseldorf📍 Mönchengladbach Heinrich-Heine University, Duesseldorf · Tests: No Intervention: Observational Cohort A Phase 2a Study of SUN-627 in Participants With Non-Active Secondary Progressive and Primary Progressive Multiple Sclerosis (SPMS/PPMS) NCT07840326Phase 23 sites📍 Atlanta📍 Raleigh📍 Columbus Sundance Biosciences, Inc. · Tests: SUN-627, Placebo "Selfie" Videos: A Novel, Patient-centered, Comprehensive Approach to Measuring Function in MS NCT07222618n/a1 site📍 San Francisco University of California, San Francisco Assessing Changes in Multi-parametric MRI in MS Patients Taking Clemastine Fumarate as a Myelin Repair Therapy NCT05359653Phase 1, Phase 21 site📍 San Francisco University of California, San Francisco · Tests: Clemastine Fumarate, Placebo Imaging the Interplay Between Axonal Damage and Repair in Multiple Sclerosis NCT05177523n/a1 site📍 Basel University Hospital, Basel, Switzerland · Tests: MRI, Neurocognitive examination for healthy subjects, blood sampling Clinnova-MS: A Prospective Cohort Study of Patients With Multiple Sclerosis (Switzerland) NCT06526364n/a1 site📍 Basel University Hospital, Basel, Switzerland · Tests: All participants will be asked to provide data and samples for collection and analysis. Definition of Autonomic Nervous System Involvement in Patients With Multiple Sclerosis NCT05748015NA2 sites📍 Telese Terme📍 Naples Istituti Clinici Scientifici Maugeri SpA · Tests: quantification of sensory and autonomic small nerve fibers by punch skin biopsy, Cardiovascular Reflexes testing, Admin… Allogenic Adipose Tissue-derived Mesenchymal Stromal Cells for the Treatment of Primary Progressive Multiple Sclerosis NCT06592703Phase 12 sites📍 Créteil📍 Rennes Rennes University Hospital · Tests: Adipose tissue-derived Mesenchymal Stromal Cells Ultra-High Resolution PET in Aging, Neurodegeneration and Psychotic Disorders NCT07509125NA1 site📍 Leuven Universitaire Ziekenhuizen KU Leuven · Tests: UHR PET/CT scan of the brain with ¹⁸F-FDG, UHR PET/CT scan of the brain with ¹⁸F-PE2I, UHR PET/CT scan of the brain wit… Neurologic Stem Cell Treatment Study NCT02795052NA3 sites📍 Westport📍 Coral Springs📍 Dubai MD Stem Cells · Tests: Intravenous and Intranasal BMSC Safety and Efficacy of S103 Cells in Progressive/Refractory Multiple Sclerosis NCT07587125Phase 11 site📍 Xi'an Xijing Hospital · Tests: S103 cells SIZOMUS Safety of Ixazomib Targeting Plasma Cells in Multiple Sclerosis NCT03783416Phase 11 site📍 London Queen Mary University of London · Tests: Ixazomib (NINLARO®) capsules / Matching placebo capsules A Study to Assess the Safety and Clinical Activity of Azer-cel in Participants With B-cell Mediated Autoimmune Disorders NCT06680037Phase 18 sites📍 La Jolla📍 Ann Arbor📍 Omaha TG Therapeutics, Inc. · Tests: Azercabtagene zapreleucel (azer-cel) A Study of Orelabrutinib in Patients With Primary Progressive Multiple Sclerosis NCT07067463Phase 371 sites📍 Pheonix📍 Scottsdale📍 West Hollywood Zenas BioPharma (USA), LLC · Tests: Orelabrutinib, Placebo MS-ResearchBiomarkerS NCT05204459n/a1 site📍 Los Angeles Cedars-Sinai Medical Center NYSCF Scientific Discovery Biobank NCT06203106n/a1 site📍 New York New York Stem Cell Foundation Research Institute · Tests: Biological Sample Collection
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