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Clinical trials test new treatments โ€” sometimes the newest options available for a disease. Find trials that are recruiting now, near you. Open one to see its eligibility rules as simple questions to go through with your doctor.

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30 recruiting trials

for Refractory Malignant Solid Tumors

A Trial of RSC-1255 for Treatment of Patients With Advanced Malignancies NCT04678648Phase 13 sites๐Ÿ“ Los Angeles๐Ÿ“ Denver๐Ÿ“ Nashville RasCal Therapeutics, Inc. ยท Tests: RSC-1255 Dose Escalation, RSC-1255 Dose Expansion CPI-613 (Devimistat) in Combination With Hydroxychloroquine and 5-fluorouracil or Gemcitabine in Treating Patients With Advanced Chemorefractory Solid Tumors NCT05733000Phase 21 site๐Ÿ“ Chicago Northwestern University ยท Tests: Biospecimen Collection, Computed Tomography, Devimistat, Fluorouracil, Gemcitabine Hydrochloride YH02 Injection for Intra-tumor Injection Therapy in Advanced Solid Tumors With Unresponsive or Failure-Treated Cases NCT07697937Phase 21 site๐Ÿ“ Tianjin Tianjin First Central Hospital ยท Tests: YH-02 Axatilimab in Combination With Retifanlimab and Paclitaxel for the Treatment of Patients With Advanced or Metastatic Solid Tumors NCT06320405Phase 1, Phase 21 site๐Ÿ“ Portland OHSU Knight Cancer Institute ยท Tests: Axatilimab, Biopsy, Biospecimen Collection, Computed Tomography, Magnetic Resonance Imaging TR-002 for the Treatment of Advanced Unresectable Metastatic Solid Tumors Unresectable or Metastatic, Refractory Pancreatic Adenocarcinoma NCT07189195Phase 11 site๐Ÿ“ Sacramento University of California, Davis ยท Tests: TR-002 A Study of Patritumab Deruxtecan in Pediatric Participants With Relapsed or Refractory Solid Tumors (MK-9999-01C/LIGHTBEAM-U01) NCT06941272Phase 1, Phase 264 sites๐Ÿ“ Los Angeles๐Ÿ“ Aurora๐Ÿ“ New Haven Merck Sharp & Dohme LLC ยท Tests: Patritumab Deruxtecan IACS-6274 With or Without Bevacizumab and Paclitaxel for the Treatment of Advanced Solid Tumors NCT05039801Phase 11 site๐Ÿ“ Houston M.D. Anderson Cancer Center ยท Tests: Bevacizumab, Glutaminase-1 Inhibitor IACS-6274, Paclitaxel, Capivasertib RAPA-201 Therapy of Solid Tumors NCT05144698Phase 1, Phase 21 site๐Ÿ“ Hackensack Rapa Therapeutics LLC ยท Tests: RAPA-201 Rapamycin Resistant T Cells, Chemotherapy Prior to RAPA-201 Therapy, Pembrolizumab (PD-1 Blocking Antibody) Safety and Efficacy of Radiotherapy Combined with Immunotherapy for Advanced Malignant Tumors. NCT06173219Phase 1, Phase 21 site๐Ÿ“ Beijing China-Japan Friendship Hospital ยท Tests: Radiotherapy combined with immunotherapy Combination of CAR-DC Vaccine and ICIs in Malignant Tumors NCT05631886Phase 11 site๐Ÿ“ Beijing Chinese PLA General Hospital ยท Tests: TP53-EphA-2-CAR-DC, Abraxane, Cyclophosphamide, anti-PD-1 antibody, Anti-CTLA4 Monoclonal Antibody Ex Vivo Drug Sensitivity Testing and Multi-Omics Profiling NCT05857969Phase 11 site๐Ÿ“ Miami Florida International University ยท Tests: Functional Precision Medicine Testing the Combination of the Anticancer Drugs ZEN003694 and Binimetinib in Patients With Advanced/Metastatic or Unresectable Solid Tumors With RAS Alterations and Triple Negative Breast Cancer NCT05111561Phase 14 sites๐Ÿ“ Boston๐Ÿ“ Boston๐Ÿ“ Galveston National Cancer Institute (NCI) ยท Tests: BET Bromodomain Inhibitor ZEN-3694, Binimetinib, Biopsy Procedure, Biospecimen Collection, Computed Tomography A Study of Ifinatamab Deruxtecan in Pediatric Participants With Relapsed or Refractory Solid Tumors (MK-9999-01D/LIGHTBEAM-U01) NCT07630974Phase 1, Phase 234 sites๐Ÿ“ Los Angeles๐Ÿ“ Aurora๐Ÿ“ St. Petersburg Merck Sharp & Dohme LLC ยท Tests: Ifinatamab Deruxtecan TLN-499 in Combination With Venetoclax in Patients With Relapsed/Refractory Solid Tumors NCT07713732Phase 13 sites๐Ÿ“ Camperdown๐Ÿ“ Malvern๐Ÿ“ Nedlands Treeline Biosciences, Inc. ยท Tests: TLN-499, Venetoclax Testing A New Anti-cancer Drug Combination, Entinostat and ZEN003694, for Advanced and Refractory Solid Tumors NCT05053971Phase 1, Phase 23 sites๐Ÿ“ New Haven๐Ÿ“ Gainesville๐Ÿ“ Oklahoma City National Cancer Institute (NCI) ยท Tests: BET Bromodomain Inhibitor ZEN-3694, Computed Tomography, Core Biopsy, Entinostat AOH1996 for the Treatment of Refractory Solid Tumors NCT05227326Phase 13 sites๐Ÿ“ Scottsdale๐Ÿ“ Duarte๐Ÿ“ Long Beach City of Hope Medical Center ยท Tests: PCNA Inhibitor AOH1996 A Study of Selinexor in People With Wilms Tumors and Other Solid Tumors NCT05985161Phase 216 sites๐Ÿ“ Los Angeles๐Ÿ“ Palo Alto๐Ÿ“ Washington D.C. Memorial Sloan Kettering Cancer Center ยท Tests: Selinexor Personalized Neo-Antigen Peptide Vaccine for the Treatment of Stage IIIC-IV Melanoma, Hormone Receptor Positive HER2 Negative Metastatic Refractory Breast Cancer or Stage III-IV Non-Small Cell Lung Cancer NCT05098210Phase 11 site๐Ÿ“ Seattle Fred Hutchinson Cancer Center ยท Tests: Neoantigen Peptide Vaccine, Nivolumab, Poly ICLC, Echocardiography Test, Multigated Acquisition Scan A Clinical Trial Evaluating IL-22BP/LNP Compound in Refractory Malignant Solid Tumors for Safety, Tolerability and Activity NCT07100210Phase 11 site๐Ÿ“ Chengdu Xingchen Peng ยท Tests: IL-22BP mRNA vaccine injection Natural History and Biospecimen Acquisition for Children and Adults With Rare Solid Tumors NCT03739827n/a3 sites๐Ÿ“ Bethesda๐Ÿ“ Portland๐Ÿ“ Houston National Cancer Institute (NCI) A Study Evaluating the Immunotherapy Treatment for Ovarian Cancer and Other Advanced Malignancies. NCT07389239Phase 1, Phase 21 site๐Ÿ“ Chicago University of Chicago ยท Tests: Decitabine, Cyclophosphamide Conditioning, NY-ESO-1 TCR/ dnTGFฮฒRII, Aldesleukin MTI-301 for the Treatment of Metastatic or Unresectable and Refractory Solid Cancers NCT06911008Phase 11 site๐Ÿ“ Jacksonville Mayo Clinic ยท Tests: Biospecimen Collection, Computed Tomography, Magnetic Resonance Imaging, Positron Emission Tomography, Questionnaire Adโ€ฆ Study of Onivyde With Talazoparib or Temozolomide in Children With Recurrent Solid Tumors and Ewing Sarcoma NCT04901702Phase 1, Phase 210 sites๐Ÿ“ Palo Alto๐Ÿ“ Aurora๐Ÿ“ Washington D.C. St. Jude Children's Research Hospital ยท Tests: Onivyde, Talazoparib, Temozolomide Mobile Health Application (PACT) to Improve Engagement in Advance Care Planning NCT04515810NA4 sites๐Ÿ“ Manhasset๐Ÿ“ New York๐Ÿ“ New York Fred Hutchinson Cancer Center ยท Tests: Internet-Based Intervention, Best Practice, Telephone-Based Intervention, Questionnaire Administration, Post-interventiโ€ฆ Gene Modified Immune Cells After Conditioning Regimen for the Treatment of Stage IIIC or IV Melanoma or Metastatic Solid Tumors NCT04119024Phase 13 sites๐Ÿ“ Duarte๐Ÿ“ Los Angeles๐Ÿ“ Stanford Anusha Kalbasi ยท Tests: Biopsy, Biospecimen Collection, Computed Tomography, Cyclophosphamide, Fludarabine Phosphate Tegavivint for the Treatment of Recurrent or Refractory Solid Tumors, Including Lymphomas and Desmoid Tumors NCT04851119Phase 1, Phase 221 sites๐Ÿ“ Birmingham๐Ÿ“ Los Angeles๐Ÿ“ Orange Children's Oncology Group ยท Tests: Biospecimen Collection, Dual X-ray Absorptiometry, Tegavivint, X-Ray Imaging Dual-Target MSLN/FAP CAR-NK Cells for Pleural and Peritoneal Mesothelioma NCT07510815Phase 1, Phase 21 site๐Ÿ“ Shenzhen Beijing Biotech ยท Tests: EB-MF-CAR-NK-01, Fludarabine, Cyclophosphamide CBL0137 for the Treatment of Relapsed or Refractory Solid Tumors, Including CNS Tumors and Lymphoma NCT04870944Phase 1, Phase 235 sites๐Ÿ“ Birmingham๐Ÿ“ Phoenix๐Ÿ“ Los Angeles Children's Oncology Group ยท Tests: Biospecimen Collection, Bone Marrow Aspirate, Bone Marrow Biopsy, Echocardiography Test, FACT Complex-targeting Curaxinโ€ฆ JL19001 Injection Alone or in Combination With Standard Therapy in Patients With Advanced Solid Tumors or Relapsed/Refractory B-Cell Non-Hodgkin Lymphoma NCT07603479Phase 11 site๐Ÿ“ Beijing Jecho Biopharmaceuticals Co., Ltd. ยท Tests: JL19001, subcutaneous injection, 1 ฮผg/kg, JL19001, subcutaneous injection, 5 ฮผg/kg, JL19001, subcutaneous injection,10 โ€ฆ Studying TAK-243 in Patients With Advanced Cancer NCT06223542Phase 11 site๐Ÿ“ Bethesda National Cancer Institute (NCI) ยท Tests: Biopsy Procedure, Biospecimen Collection, Computed Tomography, Echocardiography Test, Magnetic Resonance Imaging
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