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family history of lung cancer

A reported family history of lung cancer in one or more family members.

๐Ÿ”” Follow weekly
๐Ÿงฌ123genes / proteins with evidence
๐Ÿ’Š0drugs and clinical candidates
๐Ÿงช6recruiting trials worldwide
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Understand family history of lung cancer

Cancer ยท Cells that grow out of control
๐ŸŽ“ Learn more

What it is

Lung cancer is cancer that forms in tissues of the lung, usually in the cells that line the air passages. It is the leading cause of cancer death in both men and women.

There are two main types: small cell lung cancer and non-small cell lung cancer. These two types grow differently and are treated differently. Non-small cell lung cancer is the more common type.

Who is more likely to develop lung cancer?

From MedlinePlus: Lung Cancer (US National Library of Medicine) โ†—

๐Ÿงฌ Cancer: Cancer is a group of diseases in which some of the body's cells grow and divide without control, and can spread to other parts of the body.

โ“ Why it happens

  • Changes (mutations) build up in the genes that tell a cell when to grow, divide and die.
  • Most of these changes happen during life: tobacco, too much sun, alcohol, some infections (such as HPV and hepatitis B and C), radiation, obesity and ageing all raise the risk.
  • Some people inherit a faulty gene that raises their risk, such as BRCA1 or BRCA2.

๐Ÿซ€ What it does to the body

  • Cancer cells form a lump (tumour) that can press on or invade nearby organs.
  • They can travel through the blood or lymph to start new tumours elsewhere (metastasis).
  • Blood cancers crowd out healthy blood cells in the bone marrow.

๐Ÿงฑ Why it is hard to cure

  • Every cancer is different, even between two people with the same type - and inside one tumour.
  • Cancer cells keep changing, so they can learn to resist a medicine that worked at first.
  • Cancer cells are the body's own cells, so killing them without harming healthy cells is hard.
  • Many cancers cause no symptoms until they have spread, and a new medicine often takes more than ten years to go from the lab to patients.

๐Ÿš€ What research is trying now

  • Targeted medicines against the exact gene change in a tumour (for example EGFR, ALK or KRAS).
  • Immunotherapy that helps the immune system recognise cancer, including CAR-T cell therapy.
  • Personalised cancer vaccines built from each tumour's mutations, now in late trials.
  • Blood tests that look for tumour DNA to find cancer earlier, and AI to read scans and slides.

General information about cancer, reviewed by people; it does not describe any one person. Below: the evidence for family history of lung cancer itself.

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AI briefing

Where the science on family history of lung cancer stands, from the evidence on this page

AI reads the targets, drugs, trials and papers below and writes where the science stands โ€” every claim cited. It is shared with everyone who opens family history of lung cancer.

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Top targets

Genes and proteins ranked by Open Targets evidence (0-1)
CHRNA5 cholinergic receptor nicotinic alpha 5 subunitPROTACantibodysmall molecule๐ŸงŠ AlphaFold structure โ†— 0.47
BRCA2 BRCA2 DNA repair associatedPROTACsmall molecule๐ŸงŠ AlphaFold structure โ†— 0.45
CLPTM1L CLPTM1 likePROTACantibody๐ŸงŠ AlphaFold structure โ†— 0.42
GXYLT1 glucoside xylosyltransferase 1PROTACantibody๐ŸงŠ AlphaFold structure โ†— 0.35
SEMA6D semaphorin 6DPROTACantibody๐ŸงŠ AlphaFold structure โ†— 0.34
TERT telomerase reverse transcriptasePROTACantibodyothersmall molecule๐ŸงŠ AlphaFold structure โ†— 0.33
CHRNA3 cholinergic receptor nicotinic alpha 3 subunitPROTACantibodyothersmall molecule๐ŸงŠ AlphaFold structure โ†— 0.33
EPB41L3 erythrocyte membrane protein band 4.1 like 3PROTACantibodysmall molecule๐ŸงŠ AlphaFold structure โ†— 0.31
WNK1 WNK lysine deficient protein kinase 1PROTACsmall molecule๐ŸงŠ AlphaFold structure โ†— 0.31
IREB2 iron responsive element binding protein 2PROTACsmall molecule๐ŸงŠ AlphaFold structure โ†— 0.30
HYKK hydroxylysine kinasePROTAC๐ŸงŠ AlphaFold structure โ†— 0.30
LRATD2 LRAT domain containing 2PROTACantibody๐ŸงŠ AlphaFold structure โ†— 0.29
RAD52 RAD52 DNA repair proteinPROTACantibodysmall molecule๐ŸงŠ AlphaFold structure โ†— 0.28
PREP prolyl endopeptidasePROTACantibodysmall molecule๐ŸงŠ AlphaFold structure โ†— 0.27
FARP1 FERM, ARH/RhoGEF and pleckstrin domain protein 1PROTACantibody๐ŸงŠ AlphaFold structure โ†— 0.26

Green labels: what the target is known to be druggable by. The score combines genetics, somatic mutations, drugs, expression and literature.

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Drugs and candidates

Every medicine linked to family history of lung cancer, by how far it has got

No drugs recorded yet.

๐Ÿ›ก๏ธ

AI Cure shows public evidence (Open Targets, ClinicalTrials.gov, PubMed, openFDA, DepMap, AlphaFold) with its source, and AI summaries that cite it โ€” not medical advice and not a cure. Treatment decisions belong with your doctor. Research ideas are shared only with approved researchers and labs, who can test them. In an emergency call your local emergency number (112 in India and Europe, 911 in the US). AI Cure Terms of Use ยท Privacy