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๐Ÿ“ฐ Latest breakthroughs
๐Ÿ—บ๏ธ Disease Atlas ยท Nervous system disorder

cervical dystonia

Cervical dystonia is a neurological condition characterized by excessive pulling of the muscles of the neck and shoulder resulting in abnormal movements of the head (dystonia).Most commonly, the head turns to one side or the other.Tilting sideways, or to the back or front may also occur.The turning or tilting movements may be accompanied by shaking movement (tremor) and/or soreness of the muscles of the neck and shoโ€ฆ

๐Ÿ”” Follow weekly
๐Ÿงฌ298genes / proteins with evidence
๐Ÿ’Š14drugs and clinical candidates
๐Ÿงช9recruiting trials worldwide
โœ…1approved
๐Ÿ“ˆ5phase 3
๐Ÿ”ฌ

Understand cervical dystonia

Every other disease ยท Genes, environment and time
๐ŸŽ“ Learn more

What it is

Dystonia can affect just one muscle, a group of muscles or all of your muscles. Symptoms can include tremors, voice problems or a dragging foot. Symptoms often start in childhood. They can also start in the late teens or early adulthood. Some cases worsen over time. Others are mild.

Some people inherit dystonia. Others have it because of another disease. Researchers think that dystonia may be due to a problem in the part of the brain that handles messages about muscle contractions. There is no cure. Doctors use medicines, Botox injections, surgery, physical therapy, and other treatments to reduce or eliminate muscle spasms and pain.

NIH: National Institute of Neurological Disorders and Stroke

From MedlinePlus: Dystonia (US National Library of Medicine) โ†—

๐Ÿ”ฌ Every other disease: Most diseases come from a mix of the genes we inherit, the environment and way we live, and the passing of time.

โ“ Why it happens

  • Genes can make a person more or less likely to get a disease.
  • Environment and lifestyle - infections, diet, smoking, pollution, activity - push the risk up or down.
  • Errors build up in the body over the years, which is why many diseases are more common with age.

๐Ÿซ€ What it does to the body

  • Each disease affects the body in its own way; the summary above explains this one.

๐Ÿงฑ Why it is hard to cure

  • The biology is often only partly understood.
  • A medicine has to be both effective and safe, and proving that in clinical trials takes years.

๐Ÿš€ What research is trying now

  • Studying which genes are linked to the disease - AI Cure shows them below, ranked by evidence.
  • Testing whether medicines approved for other diseases could help.

General information about every other disease, reviewed by people; it does not describe any one person. Below: the evidence for cervical dystonia itself.

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AI briefing

Where the science on cervical dystonia stands, from the evidence on this page

AI reads the targets, drugs, trials and papers below and writes where the science stands โ€” every claim cited. It is shared with everyone who opens cervical dystonia.

๐ŸŽฏ

Top targets

Genes and proteins ranked by Open Targets evidence (0-1)
VAMP2 vesicle associated membrane protein 2PROTACantibodyother๐ŸงŠ AlphaFold structure โ†— 0.51
ANO3 anoctamin 3antibody๐ŸงŠ AlphaFold structure โ†— 0.51
SNAP25 synaptosome associated protein 25PROTACantibodyothersmall molecule๐ŸงŠ AlphaFold structure โ†— 0.42
MRPL47 mitochondrial ribosomal protein L47PROTACsmall molecule๐ŸงŠ AlphaFold structure โ†— 0.27
ACTL6A actin like 6APROTACantibodysmall molecule๐ŸงŠ AlphaFold structure โ†— 0.27
NABP1 nucleic acid binding protein 1๐ŸงŠ AlphaFold structure โ†— 0.16
SCN8A sodium voltage-gated channel alpha subunit 8PROTACantibodysmall molecule๐ŸงŠ AlphaFold structure โ†— 0.08
SPTBN4 spectrin beta, non-erythrocytic 4PROTACantibody๐ŸงŠ AlphaFold structure โ†— 0.08
CACNA1A calcium voltage-gated channel subunit alpha1 APROTACantibodysmall molecule๐ŸงŠ AlphaFold structure โ†— 0.08
CACNA1F calcium voltage-gated channel subunit alpha1 FPROTACantibodysmall molecule๐ŸงŠ AlphaFold structure โ†— 0.07
CACNA1S calcium voltage-gated channel subunit alpha1 SPROTACantibodysmall molecule๐ŸงŠ AlphaFold structure โ†— 0.07
CACNA1B calcium voltage-gated channel subunit alpha1 BPROTACantibodyothersmall molecule๐ŸงŠ AlphaFold structure โ†— 0.07
SLC18A2 solute carrier family 18 member A2PROTACantibodysmall molecule๐ŸงŠ AlphaFold structure โ†— 0.07
CACNA1D calcium voltage-gated channel subunit alpha1 DPROTACantibodysmall molecule๐ŸงŠ AlphaFold structure โ†— 0.07
SV2A synaptic vesicle glycoprotein 2APROTACantibodysmall molecule๐ŸงŠ AlphaFold structure โ†— 0.07

Green labels: what the target is known to be druggable by. The score combines genetics, somatic mutations, drugs, expression and literature.

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Drugs and candidates

Every medicine linked to cervical dystonia, by how far it has got
Approved ยท 1
RimabotulinumtoxinbVesicle-associated membrane protein 2 inhibitorApproved
In phase 2 / 3 ยท 10
AbobotulinumtoxinaSynaptosomal nerve-associated protein 25 (SNAP-25) inhibitorPhase 3
Botulinum Toxin Type ASynaptosomal nerve-associated protein 25 (SNAP-25) hydrolytic enzymePhase 3
DaxibotulinumtoxinaSynaptosomal nerve-associated protein 25 (SNAP-25) inhibitorPhase 3
IncobotulinumtoxinaSynaptosomal nerve-associated protein 25 (SNAP-25) inhibitorPhase 3
OnabotulinumtoxinaSynaptosomal nerve-associated protein 25 (SNAP-25) inhibitorPhase 3
AmlodipineVoltage-gated L-type calcium channel blockerPhase 2
Show all 10
DronabinolCannabinoid CB1 receptor agonistPhase 2
LevetiracetamSynaptic vesicle glycoprotein 2A modulator; Voltage-gated N-type calcium channel alpha-1Bโ€ฆPhase 2
Prabotulinumtoxin ASynaptosomal nerve-associated protein 25 (SNAP-25) proteolytic enzymePhase 2
ValbenazineSynaptic vesicular amine transporter inhibitorPhase 2
Early trials ยท 2
GadoliniumPhase 1/2
PerampanelGlutamate receptor ionotropic AMPA antagonistPhase 1/2
๐Ÿ›ก๏ธ

AI Cure shows public evidence (Open Targets, ClinicalTrials.gov, PubMed, openFDA, DepMap, AlphaFold) with its source, and AI summaries that cite it โ€” not medical advice and not a cure. Treatment decisions belong with your doctor. Research ideas are shared only with approved researchers and labs, who can test them. In an emergency call your local emergency number (112 in India and Europe, 911 in the US). AI Cure Terms of Use ยท Privacy