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Trial Match

Clinical trials test new treatments — sometimes the newest options available for a disease. Find trials that are recruiting now, near you. Open one to see its eligibility rules as simple questions to go through with your doctor.

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30 recruiting trials

for CNS Embryonal Tumor

Study in Children and Adolescents of 177Lu-DOTATATE (Lutathera®) Combined With the PARP Inhibitor Olaparib for the Treatment of Recurrent or Relapsed Solid Tumours Expressing Somatostatin Receptor (SSTR) (LuPARPed). NCT06607692Phase 1, Phase 21 site📍 Boadilla del Monte Fundación de investigación HM · Tests: Olaparib; 177Lu-DOTATATE Sonodynamic Therapy in Patients With Recurrent GBM NCT06039709Phase 11 site📍 Charlottesville Shayan Moosa, MD · Tests: 5-ALA and Low-Intensity Focused Ultrasound (SDT) A Phase 2 and Pharmacodynamic Study of Sitagliptin in Patients With Progressive Grade 4 Gliomas NCT07003542Phase 21 site📍 Cleveland Case Comprehensive Cancer Center · Tests: Sitagliptin Feasibility of Intra- and Post-operative Microdialysis During Neurosurgery for Central Nervous System Lesions NCT04047264NA1 site📍 Rochester Mayo Clinic · Tests: Microdialysis, Magnetic Resonance Imaging, Computed Tomography Molecular and Clinical Risk-Directed Therapy for Infants and Young Children With Newly Diagnosed Medulloblastoma NCT05535166Phase 210 sites📍 Palo Alto📍 Orlando📍 Tampa St. Jude Children's Research Hospital · Tests: Surgical resection, Ommaya/VPS, Methotrexate, Cisplatin, Vincristine Application of FET-PET in Fusion With MRI in the Treatment of Glioblastoma Multiforme [TYR-GLIO] NCT06466031NA1 site📍 Lodz Copernicus Memorial Hospital · Tests: MRI & PET fusion, MRI+T1C Natural History Study of Patients With Neurofibromatosis Type 2 NCT00598351n/a1 site📍 Bethesda National Institute of Neurological Disorders and Stroke (NI… Evaluation of the CONVIVO System NCT05139277NA1 site📍 Lebanon Dartmouth-Hitchcock Medical Center · Tests: CONVIVO system, Conventional histologic evaluation ETMR One: An International Registry and Research Platform for Children With Embryonal Tumor With Multilayer Rosettes NCT04794686n/a1 site📍 Hackensack Hackensack Meridian Health A Study of BMS-986504 Monotherapy and in Combination With Other Agents in Participants With Advanced and/or Metastatic Solid Tumors With Homozygous MTAP Deletion (MountainTAP-5) NCT07492680Phase 258 sites📍 San Francisco📍 Aurora📍 Atlanta Bristol-Myers Squibb · Tests: BMS-986504, Daraxonrasib, Nivolumab + Relatlimab FDC, Temozolomide, Pumitamig Pilot IntraOperative Neuronal Electrophysiology in Tumor rElatEd suRgery NCT06617208NA1 site📍 Rotterdam Erasmus Medical Center · Tests: Neuropixel probe recording Window Trial of Fluorescently Labeled Nivolumab-IRDye800 (Nivo800) in High Grade Glioma (HGG) NCT07210632EARLY Phase 11 site📍 Nashville Eben Rosenthal · Tests: Nivolumab, Nivolumab-IRDye800 Avapritinib for the Treatment of CKIT or PDGFRA Mutation-Positive Locally Advanced or Metastatic Malignant Solid Tumors NCT04771520Phase 21 site📍 Houston M.D. Anderson Cancer Center · Tests: Avapritinib Molecular Analysis of Samples From Patients With Diffuse Intrinsic Pontine Glioma and Brainstem Glioma NCT01106794n/a1 site📍 Washington D.C. Children's National Research Institute Ruxolitinib With Radiation and Temozolomide Compared to Radiation and Temozolomide for Newly Diagnosed Glioblastoma NCT06991101Phase 22 sites📍 Miami📍 New York Baptist Health South Florida · Tests: Ruxolitinib, Temozolomide, Radiation Therapy Study of Silevertinib With Temozolomide for the Treatment of Newly Diagnosed GBM With Unmethylated MGMT and EGFRvIII NCT07326566Phase 235 sites📍 Birmingham📍 Springdale📍 La Jolla Black Diamond Therapeutics, Inc. · Tests: silevertinib in combination with temozolomide, temozolomide (TMZ) HOBSCOTCH-CA (HOme-Based Self-management and COgnitive Training CHanges Lives in Brain CAncer) NCT06930846NA1 site📍 Lebanon Dartmouth-Hitchcock Medical Center · Tests: HOBSCOTCH-CA Safety Study of the Repeated Opening of the Blood-brain Barrier With the SonoCloud® Device to Treat Malignant Brain Tumors in Pediatric Patients NCT05293197Phase 13 sites📍 Paris📍 Paris📍 Villejuif Assistance Publique - Hôpitaux de Paris · Tests: SonoCloud® (9 transducers) Atovaquone Combined With Radiation in Children With Malignant Brain Tumors NCT06624371Phase 12 sites📍 Atlanta📍 Atlanta Emory University · Tests: Atovaquone, Radiation Therapy Focused Ultrasound Blood-Brain Barrier Disruption for the Treatment of High-Grade Glioma in Patients Undergoing Standard Chemotherapy NCT07179328Phase 11 site📍 Toronto Sunnybrook Health Sciences Centre · Tests: Focused Ultrasound Next Generation Dome Helmet, Definity® Vial for (Perflutren Lipid Microsphere) Injectable Suspension An Phase Ib/II Clinical Trial of TCC1727 Combination Therapy in Advanced Solid Tumors NCT07371663Phase 1, Phase 23 sites📍 Beijing📍 Zhengzhou📍 Hangzhou Beijing Tide Pharmaceutical Co., Ltd · Tests: TCC1727 tablet 90mg, TCC1727 tablet 120mg, TCC1727 tablet 160mg, benmelstobart Injection Key Longitudinal Associations With Risk and Glioblastoma Outcomes NCT06625684n/a1 site📍 Durham Duke University Combination Therapy for the Treatment of Diffuse Midline Gliomas NCT05009992Phase 232 sites📍 Birmingham📍 Los Angeles📍 San Diego University of California, San Francisco · Tests: ONC201, Radiation Therapy, Paxalisib, DNX-2401 Precision Radiotherapy Enabled by Molecular MRI NCT07512154NA1 site📍 Baltimore Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins · Tests: Amide proton transfer radiotherapy, Standard radiotherapy Immunotherapy for Solid Tumor Malignancies in Pediatrics Using Interleukin-15 and -21 Armored Glypican-3-specific Chimeric Antigen Receptor T Cells NCT07148050Phase 11 site📍 Seattle Seattle Children's Hospital · Tests: SC-CAR.GPC3xIL15.21 CAR T cells Impact of Salovum® and SPC® Flakes on Brain Tumor Induced Edema NCT06710249Phase 21 site📍 Lund Peter Siesjö · Tests: Salovum/SPC flakes GPC-3 CAR T CELLS FOR Recurrent GPC-3 Positive Glioblastoma NCT06815432Phase 11 site📍 Houston Baylor College of Medicine · Tests: 15.GPC3-CAR T cells Rare Embryonal Tumors of the Central Nervous System: International Registry NCT05711992n/a11 sites📍 Yerevan📍 Ottawa📍 Budapest Immune Oncology Research Institute Engineering Immune Organoids to Study Pediatric Cancer NCT05890781NA2 sites📍 Villejuif📍 Paris Gustave Roussy, Cancer Campus, Grand Paris · Tests: Skin biopsy, Fresh tumor sample, Blood sample, Healthy tissue from the tumor, Spinal cerebrospinal fluid (SCF) ONC206 for Treatment of Newly Diagnosed, Recurrent Diffuse Midline Gliomas, and Other Recurrent Malignant CNS Tumors NCT04732065Phase 17 sites📍 San Francisco📍 Washington D.C.📍 Atlanta Sabine Mueller, MD, PhD · Tests: ONC206, Standard of Care Radiation Therapy, Optional Proton (1H) MR spectroscopy (MRS)
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