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Clinical trials test new treatments — sometimes the newest options available for a disease. Find trials that are recruiting now, near you. Open one to see its eligibility rules as simple questions to go through with your doctor.

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30 recruiting trials

for Heart Failure With Reduced Ejection Fraction (HFrEF)

Eccentric Muscle Training in Cardiac Rehabilitation NCT07636343NA1 site📍 Edegem University Hospital, Antwerp · Tests: eccentric bike training, eccentric overload training, aerobic treadmill training, aerobic bike training, traditional dy… Predictive Factors of Response to Phase II Cardiac Rehabilitation in Heart Failure With Reduced Ejection Fraction NCT07164911n/a1 site📍 Corbie Centre Hospitalier de Corbie Effect of Pre-Hospital ARNI Therapy on Short-Term Outcomes in HFrEF NCT07347925n/a1 site📍 Al Mansurah Future University in Egypt · Tests: Prehospital ARNI use, No prehospital ARNI use Pulmonary Artery Catheterization and Carvedilol Early Initiation in Cardiogenic SHOCK Due to HFrEF NCT06078436NA1 site📍 Seoul Min-Seok Kim · Tests: Pulmonary artery catheter Ketones, SGLT2, HFrEF NCT06229678EARLY Phase 11 site📍 San Antonio The University of Texas Health Science Center at San Antonio · Tests: Empagliflozin 25 MG Oral Tablet, Placebo, Acipimox 250 Mg Oral Capsule Acute and Chronic Effects of Oral Ketones in Subjects With HFrEF and Diabetes NCT06108076EARLY Phase 11 site📍 San Antonio The University of Texas Health Science Center at San Antonio · Tests: Ketone Monoester (KE) AI-Based Monitoring System for Chronic Heart Failure With Advanced Wearable and Mini-Invasive Devices NCT06909682n/a1 site📍 Salerno University of Salerno · Tests: Intervention Group (Device Group - AI-Based Remote Monitoring), Standard Clinical Follow-Up Comparative Effectiveness of Carvedilol Versus Metoprolol Succinate in Heart Failure Patients With an Implantable Cardioverter Defibrillator NCT06964464Phase 413 sites📍 Scottsdale📍 Rome📍 Shawnee Mission University of Rochester · Tests: Metoprolol Succinate, Carvedilol Exercise Rehabilitation for Cardiorenal Syndrome in HFrEF Patients NCT07167368NA1 site📍 Nantong Haiyan Pan · Tests: Standardized Basic Drug Therapy for HFrEF with Chronic Kidney Dysfunction, Home-based Personalized Exercise Rehabilitat… Swedish Cardiac And Renal Failure Study-1 NCT07029503Phase 21 site📍 Stockholm Karolinska Institutet · Tests: Eplerenone Olive Oil Supplementation for Heart Failure With Reduced Ejection Fraction NCT07644806NA1 site📍 Norfolk Old Dominion University · Tests: Extra-virgin olive oil An Observational Study to Learn More About the Use of Vericiguat in Korean People With Chronic Heart Failure With Reduced Ejection Fraction (HFrEF) in Real-world Setting NCT06148935n/a1 site📍 Multiple Locations Bayer · Tests: Vericiguat (Verquvo, BAY1021189) HFrEF Polypill in Sri Lanka RCT NCT07569640Phase 312 sites📍 Kandy📍 Anuradhapura📍 Kurunegala Washington University School of Medicine · Tests: Usual Care, HFrEF Polypill Vietnamese Rapid Acceleration Protocol for Intensifying Drug Therapy in Heart Failure With Reduced Ejection Fraction NCT06595290NA4 sites📍 Long Xuyen📍 Ho Chi Minh City📍 Ho Chi Minh City University Medical Center Ho Chi Minh City (UMC) · Tests: High intensity care, Usual care Correlation of Typical LBBB Mechanical Activation Pattern by 2D Strain Echocardiography With Acute GWE Improvement in Patients Receiving LBBp or Conventional BiVp for Cardiac Resynchronization Therapy (Echo LBBp) NCT06689111NA1 site📍 Pátrai University Hospital of Patras · Tests: Left bundle branch pacing lead, CRT with the standard method through cs Digital Remote Management Versus Usual Care for Optimization of Guideline-directed Medical Therapy in Patients With Heart Failure and Reduced Ejection Fraction: a Multicentre, Randomised, Controlled Trial (DigiCare-HFrEF) NCT07352891NA6 sites📍 Beijing📍 Beijing📍 Dalian Beijing Anzhen Hospital · Tests: Digital Remote Management Pharmacological Optimization in Prevention in Heart Failure: A Sex-gap? NCT07295522Phase 412 sites📍 San Donato Milanese📍 Ancona📍 Cecina IRCCS Policlinico S. Donato · Tests: Guideline-Directed Medical Therapy (GDMT) Atrial Shunt for the Treatment of Heart Failure With Reduced Ejection Fraction NCT07820410Phase 2, Phase 31 site📍 Beijing Beijing Anzhen Hospital · Tests: D-shant Atrial Shunt, Guideline-Directed Medical Therapy (GDMT) for heart failure with reduced ejection fraction Feasibility and Effectiveness of a Ring-Type Blood Pressure Device (CART-BP) Compared With 24-Hour Ambulatory Blood Pressure Monitoring in HFrEF NCT07626879n/a1 site📍 Daegu Keimyung University Dongsan Medical Center Study Assessing Left Ventricular Administration of a Genetic Medicine Directing Organ Regeneration in Heart Failure NCT06831825Phase 11 site📍 Houston Medley Therapeutics · Tests: YAP101 (AAV9-Sav-shRNA) PRIME HFrEF: Novel Exercise for Older Patients With Heart Failure With Reduced Ejection Fraction NCT05609097NA1 site📍 Charlottesville University of Virginia · Tests: PRIME, COMBO Colchicine in Acutely Decompensated HFREF NCT06286423Phase 41 site📍 Charlottesville University of Virginia · Tests: Colchicine 0.6 mg, Control/Placebo group A Trial of CRD-4730 in HFrEF NCT07750873Phase 22 sites📍 Pasadena📍 Bloomfield Hills Cardurion Pharmaceuticals, Inc. · Tests: CRD-4730, Placebo Comparison of Three-dimensional and Two-dimensional Left Ventricle Strain With Speckle-tracking Echocardiography in Heart Failure With Reduced and Mildly Reduced Ejection Fraction NCT07741305n/a5 sites📍 Bari📍 Milan📍 Pavia Istituti Clinici Scientifici Maugeri SpA Modulation of SERCA2a of Intra-myocytic Calcium Trafficking in Heart Failure With Reduced Ejection Fraction NCT04703842Phase 1, Phase 25 sites📍 San Diego📍 San Francisco📍 St Louis Sardocor Corp. · Tests: SRD-001, Placebo Telemonitoring to Optimize Medication Titration for Heart Failure: a Feasibility Study NCT07016815NA2 sites📍 Hong Kong📍 Hong Kong Chinese University of Hong Kong · Tests: Wearable wrist heart rate and activity monitor, Bluetooth enabled body weight scale with bioimpedance analysis, Bluetoo… Heart Failure in Patients With Diabetes: Cells, Crosstalk and Consequences NCT06774014n/a1 site📍 Leeds University of Leeds Single and Twice-daily Dosing of Ramipril on Renal Function in Chronic Kidney Disease Patients With Reduced Ejection Fraction Heart Failure NCT07259512Phase 41 site📍 Kartasura Evi Liliek Wulandari · Tests: Ramipril Guideline Implementation and Quality of Care Evaluation in Patients With Heart Failure and Reduced Ejection Fraction (HFrEF) NCT07702760n/a1 site📍 Rotterdam Jasper Brugts MD PhD Telemedicine-guided Uptitration of Therapy in Chronic Heart Failure NCT07518030NA1 site📍 Piacenza Azienda Unita Sanitaria Locale di Piacenza · Tests: Telemedicine-based follow-up, Standard follow-up
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