🌐 EnglishEN

AI Cure is a research tool showing open data. Not medical advice. Discuss with your doctor. Terms

🧪

Trial Match

Clinical trials test new treatments — sometimes the newest options available for a disease. Find trials that are recruiting now, near you. Open one to see its eligibility rules as simple questions to go through with your doctor.

Know your stage or your test results (such as EGFR, HER2 or BRCA)? Match trials to your own profile - nothing you type is saved.

🎯 Match trials to me

22 recruiting trials

for Hereditary Spastic Paraplegia

Phase 3 Efficacy Study With Concurrent Control of IT MELPIDA in SPG50.Concurrent Controls. NCT06692712Phase 32 sites📍 Dallas📍 Barcelona Elpida Therapeutics SPC · Tests: MELPIDA Registry and Natural History Study for Early Onset Hereditary Spastic Paraplegia NCT04712812n/a1 site📍 Boston Boston Children's Hospital Gait Analysis Parameter and Upper Limb Evaluation in Adult Patients With Neurological or Metabolic Pathology NCT07136844NA1 site📍 Liège Centre Hospitalier Universitaire de Liege · Tests: Syde, Dynamometric measurements of muscle strength, The 6-minute walk test (6MWT), The 10-meter test (10MWT), The 4 sta… Rare Disease Registry Database for Movement Disorders in Southern Anhui Province NCT07838883n/a1 site📍 Wuhu First Affiliated Hospital of Wannan Medical College Spastic Paraplegia - Centers of Excellence Research Network NCT06553976n/a11 sites📍 Miami📍 Iowa City📍 Boston Boston Children's Hospital Phenotypes, Biomarkers and Pathophysiology in Hereditary Spastic Paraplegias and Related Disorders NCT03981276n/a13 sites📍 Innsbruck📍 Bonn📍 Erlangen Dr. Rebecca Schule · Tests: Clinical rating scale to measure disease severity and progression, Next-Gen Sequencing (NGS) The Effect of Targeting the Plantaris Muscle-tendon in Surgical Correction of Ankle Equinus in Children NCT07090057NA1 site📍 Edmonton University of Alberta · Tests: Tendoachilles (TA) lengthening or gastrocnemius (GN) recession, then Plantaris tenotomy, Plantaris tenotomy, then Tendo… TreatHSP Platform: Adaptive Natural History Platform for Ataxias, HSPs, and Spastic Ataxias NCT07798674n/a30 sites📍 Innsbruck📍 Prague📍 Paris Heidelberg University A Natural History Study Seeks to Understand the Clinical, Genomic, Pharmacological, Laboratory, and Dietary Determinates of Pyrimidine and Purine Metabolism Disorders NCT06092346n/a1 site📍 Bethesda National Human Genome Research Institute (NHGRI) The preSPG4 Study - Studying the Prodromal and Early Phase of SPG4 NCT03206190NA1 site📍 Tübingen University Hospital Tuebingen · Tests: SPRS Score and clinical signs, Cognition Testing using CANTAB, Lumbar Puncture and blood draw, MRI, Electrophysiology Melpida: Recombinant Adeno-associated Virus (Serotype 9) Encoding a Codon Optimized Human AP4M1 Transgene (hAP4M1opt) NCT05518188Phase 1, Phase 21 site📍 Dallas Elpida Therapeutics SPC · Tests: MELPIDA Evaluation of an Intensive Training Program for Patients with Hereditary Spastic Paraparesis SPG4/Spast NCT06229626NA1 site📍 Paris Assistance Publique - Hôpitaux de Paris · Tests: intensive reeducation Neuromodulation to Enhance Motor Function in HSP NCT07417943NA1 site📍 Lexington Rahul Sachdeva · Tests: transcutaneous spinal cord stimulation STOP-HSP.Net: a Registry for Hereditary Spastic Paraplegia as an Integration Tool for Future Therapeutic Strategies NCT06572046n/a1 site📍 Pisa IRCCS Fondazione Stella Maris Hereditary Spastic Paraplegia Genomic Sequencing Initiative (HSPseq) NCT05354622n/a1 site📍 Boston Boston Children's Hospital Natural History Study of Patients with HPDL Mutations NCT05848271n/a1 site📍 San Diego University of California, San Diego · Tests: Patient Registry, Dry blood spots sampling Robot-assisted Walking Treatment in Hereditary Spastic Paraplegia (HSP) NCT06728787n/a1 site📍 Bosisio Parini IRCCS Eugenio Medea · Tests: Robot-Assisted Gait Training Calcium Folinate Treatment of Spastic Paraplegia 56 NCT06478238EARLY Phase 11 site📍 Shanghai Shanghai 6th People's Hospital · Tests: calcium folinate A Prospective Cohort Study of ITB Treatment for HSP NCT06844734n/a1 site📍 Shanghai Shanghai 6th People's Hospital Effects of Whole-body Electrical Muscle Stimulation Exercise on Adults With Neuromuscular Disease NCT07478172NA1 site📍 Columbia University of Missouri-Columbia · Tests: Whole-body Electrical Muscle Stimulation Exercise A Prospective Cohort Study of Surgical Treatment for Foot Deformities in HSP NCT06936163n/a1 site📍 Shanghai Shanghai 6th People's Hospital Flexibility, Resistance, Aerobic, Movement Execution Training in Adults With Hereditary Spastic Paraplegia NCT06742697NA2 sites📍 Bosisio Parini📍 Pieve di Soligo IRCCS Eugenio Medea · Tests: Flexibility, Resistance, Aerobic, Movement Execution training
🛡️

AI Cure shows public evidence (Open Targets, ClinicalTrials.gov, PubMed, openFDA, DepMap, AlphaFold) with its source, and AI summaries that cite it — not medical advice and not a cure. Treatment decisions belong with your doctor. Research ideas are shared only with approved researchers and labs, who can test them. In an emergency call your local emergency number (112 in India and Europe, 911 in the US). AI Cure Terms of Use · Privacy