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Trial Match

Clinical trials test new treatments — sometimes the newest options available for a disease. Find trials that are recruiting now, near you. Open one to see its eligibility rules as simple questions to go through with your doctor.

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30 recruiting trials

for Metastatic Malignant Neoplasm in the Brain

ioMRI in the Surgery of Brain Metastases. NCT07197632NA1 site📍 Munich Technical University of Munich · Tests: Surgery with intraoperative MRI Neoadjuvant Stereotactic Radiotherapy for Brain Metastasis NCT06933199NA4 sites📍 Ostrava📍 Brno📍 Hradec Králové University Hospital Ostrava · Tests: Neoadjuvant Stereotactic Radiotherapy (NaSRT), Postoperative Stereotactic Radiotherapy (SRT) A Study to Evaluate the Efficacy of Osimertinib With Early Intervention SRS Treatment Compared to the Continuation of Osimertinib Alone, in Patients With EGFR Mutated NSCLC and Asymptomatic Brain Metastases NCT05033691NA1 site📍 Jerusalem Hadassah Medical Organization · Tests: Stereotactic surgery Brain [18F]-FES PET/CT in Patients With Estrogen-Receptor Positive Breast Cancer NCT06072807Phase 41 site📍 New York Weill Medical College of Cornell University · Tests: Brain Imaging with 18F-FES Phase II Study of Dato-DXd in Triple-negative Breast Cancer Patients With Newly Diagnosed or Progressing Brain Metastases NCT05866432Phase 21 site📍 Vienna Medical University of Vienna · Tests: Datopotamab deruxtecan Feasibility of Intra- and Post-operative Microdialysis During Neurosurgery for Central Nervous System Lesions NCT04047264NA1 site📍 Rochester Mayo Clinic · Tests: Microdialysis, Magnetic Resonance Imaging, Computed Tomography EXCLAIM: Exploring Combined Local and Systemic Approaches In Brain Metastasis: a Multi-cohort Randomized Phase II Study Evaluating Initial Response to Systemic Therapy and Subsequent Integration of Stereotactic Radiosurgery in Patients With Low-risk Brain Metastases and Central Nervous System-active NCT06649058Phase 21 site📍 Houston M.D. Anderson Cancer Center · Tests: Systemic Therapy, Stereotactic Radiosurgery DATO-BASE: DATOpotamab-deruxtecan for Breast Cancer Brain metAstaSEs NCT06176261Phase 23 sites📍 Miami📍 Boston📍 Durham Nancy Lin, MD · Tests: Datopotamab Deruxtecan WBRT With Hippocampal-avoidance Technique Followed by SRT for Extensive-stage SCLC With Baseline Brain Metastases NCT06243003Phase 1, Phase 21 site📍 Shanghai Fudan University · Tests: HA-WBRT plus SBRT Asciminib in HER2+ Breast Cancer Brain Metastases NCT07136428Phase 1, Phase 21 site📍 Durham Duke University · Tests: Asciminib and Trastuzumab Evaluation of the CONVIVO System NCT05139277NA1 site📍 Lebanon Dartmouth-Hitchcock Medical Center · Tests: CONVIVO system, Conventional histologic evaluation Pilot IntraOperative Neuronal Electrophysiology in Tumor rElatEd suRgery NCT06617208NA1 site📍 Rotterdam Erasmus Medical Center · Tests: Neuropixel probe recording A Study of a Selective ERBB2 Inhibitor (CGT4255), in Patients With Advanced Solid Tumors NCT07361562Phase 115 sites📍 Scottsdale📍 Scottsdale📍 New Haven Cogent Biosciences, Inc. · Tests: CGT4255 A Pivotal Phase II Clinical Trial of Utidelone Injection Plus Capecitabine in HER2-negative Breast Cancer Patients With Brain Metastases NCT06764940Phase 212 sites📍 Duarte📍 Los Angeles📍 San Diego Biostar Pharma, Inc. · Tests: Utidelone, Utidelone in combination with capecitabine, Utidelone in combination with capecitabine, Utidelone in combina… Trial of Differential Margins in Single Isocenter Radiosurgery of Brain Metastases NCT06857006NA1 site📍 Birmingham University of Alabama at Birmingham · Tests: brain metastases radiosurgery Advanced Diffusion MRI to Differentiate Tumor Recurrence From Pseudoprogression in Patients With Glioblastoma and Brain Metastases NCT05911230NA1 site📍 Basel University Hospital, Basel, Switzerland · Tests: Advanced diffusion-weighted MRI (ADW-MRI) 18F-FLUC PET/MR in Patients With Brain Mets NCT06159335Phase 31 site📍 Madison University of Wisconsin, Madison · Tests: F-Fluciclovine radiotracer Repotrectinib in ROS1-positive Non-small Cell Lung Cancer Patients With Active Brain Metastasis NCT06315010Phase 217 sites📍 Graz📍 Vienna📍 München MedSIR · Tests: Repotrectinib A Ketogenic Diet as a Complementary Treatment on Patients With High-grade Gliomas and Brain Metastases NCT05564949NA2 sites📍 Chaïdári📍 Athens Attikon Hospital · Tests: CKD Registry of Patients With Brain Tumors Treated With STaRT (GammaTiles) NCT04427384n/a54 sites📍 Phoenix📍 Little Rock📍 Castro Valley GT Medical Technologies, Inc. · Tests: GammaTile Laser Interstitial Thermal Therapy (LITT) or Surgery and Adjuvant Reirradiation for Recurrent Brain Metastases (LaSAR BeaM) NCT07053033Phase 21 site📍 Houston M.D. Anderson Cancer Center · Tests: Surgery, LITT A First-In-Human, Phase 1 Study Evaluating Oral TACC3 PPI Inhibitor, AO-252, in Advanced Solid Tumors With or Without Brain Metastases NCT06136884Phase 16 sites📍 Detroit📍 Oklahoma City📍 Charleston A2A Pharmaceuticals Inc. · Tests: AO-252 Characterization of Circulating and Tumor-infiltrating Immune Cells in Malignant Brain Tumors NCT05831631n/a1 site📍 Milan Pietro Mortini, MD, Prof. · Tests: Circulating leukocytes immunophenotype, Tumor sampling A Phase 0/1 Clinical Trial With an Expansion Phase of GSK5764227, a B7-H3-Targeted Antibody-Drug Conjugate (ADC), in Patients With Recurrent Grade 4 Glioma and Patients With Brain Metastases NCT07268053EARLY Phase 11 site📍 Phoenix Nader Sanai · Tests: Risvutatug rezetecan MRI Screening for Brain Metastases Among Patients With Triple Negative or HER2+ Stage II or III Breast Cancer NCT06247449NA1 site📍 Toronto Sunnybrook Health Sciences Centre · Tests: Brain imaging, Analysis of circulating tumor DNA, Testing Morbidities Index Circulating Biomarkers Repository in Adults Diagnosed With Primary and Metastatic Brain Tumors NCT05480644n/a1 site📍 Durham Duke University A Single Arm, Phase 2 Study of Datopotamab Deruxtecan, Carboplatin, and Pembrolizumab for Treatment-naive Brain Metastases From NSCLC (Non-small Cell Lung Cancer) NCT06822543Phase 213 sites📍 Fortaleza📍 Salvador📍 Belo Horizonte Latin American Cooperative Oncology Group · Tests: Pembrolizumab, Datopotamab deruxtecan, Carboplatin Personalized Radiotherapy for Individualized Treatment Strategies and Monitoring (PRISM) NCT07139990Phase 11 site📍 Dallas University of Texas Southwestern Medical Center · Tests: Cohort A: Extensive Stage Small Cell Lung Cancer (ES-SCLC) Thoracic Tumor PULSAR (Personalized ultrahypofractionated st… Exploration of the Safety and Efficacy of T-DXd Concurrent With Brain Radiotherapy in Patients With Brain Metastases HER2-positive/HER2-low Advanced Breast Cancer NCT07117864NA1 site📍 Beijing QIAO LI · Tests: T-DXd concurrent brain radiotherapy A Prospective, Multicenter, Observational Cohort Study to Evaluate the Efficacy and Safety of a Novel Anti-tumor Drug as a Radiosensitizer in Patients With Advanced Breast Cancer Brain Metastasis. NCT06839547n/a1 site📍 Beijing Cancer Institute and Hospital, Chinese Academy of Medical S… · Tests: Radiotherapy + Novel Anti-tumor Drug
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