๐ŸŒ EnglishEN

AI Cure is a research tool showing open data. Not medical advice. Discuss with your doctor. Terms

๐Ÿงช

Trial Match

Clinical trials test new treatments โ€” sometimes the newest options available for a disease. Find trials that are recruiting now, near you. Open one to see its eligibility rules as simple questions to go through with your doctor.

Know your stage or your test results (such as EGFR, HER2 or BRCA)? Match trials to your own profile - nothing you type is saved.

๐ŸŽฏ Match trials to me

30 recruiting trials

for Advanced Non-small Cell Lung Cancer With KRAS G12C Mutation

Study of RAS(ON) Inhibitors in Patients With Advanced RAS-mutated NSCLC NCT06162221Phase 1, Phase 298 sites๐Ÿ“ Gilbert๐Ÿ“ Duarte๐Ÿ“ Irvine Revolution Medicines, Inc. ยท Tests: RMC-6291, RMC-6236, Pembrolizumab, Cisplatin, Carboplatin Sotorasib in Combination With Trastuzumab Deruxtecan for the Treatment of Locally Advanced and Metastatic Non-small Cell Lung Cancer With a KRAS G12C Mutation NCT07012031Phase 1, Phase 29 sites๐Ÿ“ Sacramento๐Ÿ“ Tampa๐Ÿ“ Tampa National Cancer Institute (NCI) ยท Tests: Biopsy Procedure, Biospecimen Collection, Computed Tomography, Echocardiography Test, Magnetic Resonance Imaging KO-2806 Monotherapy and Combination Therapies in Advanced Solid Tumors NCT06026410Phase 138 sites๐Ÿ“ Phoenix๐Ÿ“ Tucson๐Ÿ“ Los Angeles Kura Oncology, Inc. ยท Tests: Darlifarnib, Cabozantinib, Adagrasib A Study of Calderasib (MK-1084) Plus Pembrolizumab (MK-3475) in Participants With KRAS G12C Mutant Non-small Cell Lung Cancer (NSCLC) With Programmed Cell Death Ligand 1 (PD-L1) Tumor Proportion Score (TPS) โ‰ฅ50% (MK-1084-004/KANDLELIT-004) NCT06345729Phase 3246 sites๐Ÿ“ Bakersfield๐Ÿ“ Beverly Hills๐Ÿ“ Stamford Merck Sharp & Dohme LLC ยท Tests: Calderasib, Placebo, Pembrolizumab JAB-21822 Combined With JAB-3312 Compared SOC in the First Line for Treatment of Advanced Non-small Cell Lung Cancer With KRAS p.G12C Mutation NCT06416410Phase 337 sites๐Ÿ“ Hefei๐Ÿ“ Beijing๐Ÿ“ Beijing Allist Pharmaceuticals, Inc. ยท Tests: JAB-21822, Tislelizumab, JAB-3312, Pemetrexed, Carboplatin A Study of JAB-21822 in Advanced or Metastatic NSCLC With KRAS p.G12C and STK11 Co-mutation and Wild-type KEAP1 NCT05276726Phase 1, Phase 221 sites๐Ÿ“ Beijing๐Ÿ“ Beijing๐Ÿ“ Beijing Allist Pharmaceuticals, Inc. ยท Tests: JAB 21822 IBI351 Plus Cetuximab ฮฒ in Untreated Advanced Non-small Cell Lung Cancer With KRAS G12C Mutation NCT07198841Phase 27 sites๐Ÿ“ Guangzhou๐Ÿ“ Beijing๐Ÿ“ Foshan Guangdong Association of Clinical Trials ยท Tests: IBI351 combined with cetuximab ฮฒ A Phase Ib Study of JMKX001899 in Combination With Other Therapies in Advanced NSCLC Harboring KRAS G12C Mutation NCT06946927Phase 11 site๐Ÿ“ Guangzhou Jemincare ยท Tests: JMKX001899, IN10018, Chemotherapy: Pemetrexed, Carboplatin A Clinical Study of Calderasib (MK-1084) and Other Treatments for Participants With Non-Small Cell Lung Cancer (MK-1084-007/KANDLELIT-007) NCT07190248Phase 3221 sites๐Ÿ“ Birmingham๐Ÿ“ Farmington๐Ÿ“ Stamford Merck Sharp & Dohme LLC ยท Tests: Calderasib, Pembrolizumab (+) Berahyaluronidase alfa, Pemetrexed, Cisplatin, Carboplatin A Study to Find a Suitable Dose of ASP5834 in Adults With Solid Tumors NCT07094204Phase 120 sites๐Ÿ“ Santa Monica๐Ÿ“ Atlanta๐Ÿ“ Jefferson Astellas Pharma Inc ยท Tests: ASP5834, panitumumab A Study of Adagrasib Plus Pembrolizumab Plus Chemotherapy vs. Placebo Plus Pembrolizumab Plus Chemotherapy in Participants With Previously Untreated Non-squamous Non-small Cell Lung Cancer With KRAS G12C Mutation (KRYSTAL-4) NCT06875310Phase 3351 sites๐Ÿ“ Birmingham๐Ÿ“ Springdale๐Ÿ“ Fullerton Mirati Therapeutics Inc. ยท Tests: Adagrasib, Pembrolizumab, Carboplatin, Pemetrexed, Placebo A First-in-Human Trial of BLU-924 (SAR449336) in Advanced Solid Tumors Harboring KRAS Mutations NCT07629960Phase 1, Phase 216 sites๐Ÿ“ Sarasota๐Ÿ“ Tampa๐Ÿ“ Baton Rouge Blueprint Medicines Corporation ยท Tests: BLU-924 Carfilzomib in Combination With Sotorasib for the Treatment of Patients With KRAS G12C Mutated Advanced or Metastatic Non-small Cell Lung Cancer NCT06249282Phase 12 sites๐Ÿ“ Duarte๐Ÿ“ Irvine City of Hope Medical Center ยท Tests: Biopsy, Biospecimen Collection, Carfilzomib, Computed Tomography, Echocardiography A Phase 2 Clinical Study of Combination Therapy With ABSK043 and Glecirasib NCT07164170Phase 217 sites๐Ÿ“ Hefei๐Ÿ“ Beijing๐Ÿ“ Beijing Abbisko Therapeutics Co, Ltd ยท Tests: ABSK043 in combination with Glecirasib A Clinical Trial of Calderasib (MK-1084) and Durvalumab in People With Non-Small Cell Lung Cancer (MK-1084-015/KANDLELIT-015) NCT07554339Phase 3103 sites๐Ÿ“ Savannah๐Ÿ“ Lisle๐Ÿ“ Lincoln Merck Sharp & Dohme LLC ยท Tests: Calderasib, Durvalumab, Placebo to MK-1084 KEYMAKER-U01 Substudy 01J: A Study of Pembrolizumab Plus MK-1084 in Participants With Non-Small Cell Lung Cancer (NSCLC) With Kirsten Rat Sarcoma Viral Oncogene Homolog (KRAS) G12C Mutations (MK-3475-01J/KEYMAKER-U01J) NCT07252739Phase 239 sites๐Ÿ“ Clermont๐Ÿ“ Fargo๐Ÿ“ Sioux Falls Merck Sharp & Dohme LLC ยท Tests: MK-1084, Pembrolizumab, Cetuximab, Sacituzumab tirumotecan (sac-TMT), Rescue medication Ladarixin With Sotorasib in Advanced NSCLC NCT05815173Phase 16 sites๐Ÿ“ Garden City๐Ÿ“ Mineola๐Ÿ“ New Hyde Park NYU Langone Health ยท Tests: Sotorasib, Ladarixin Phase 2 Trial of Adagrasib Monotherapy and in Combination With Pembrolizumab and a Phase 3 Trial of Adagrasib in Combination in Patients With a KRAS G12C Mutation KRYSTAL-7 NCT04613596Phase 2, Phase 3770 sites๐Ÿ“ Goodyear๐Ÿ“ Prescott Valley๐Ÿ“ Safford Mirati Therapeutics Inc. ยท Tests: Adagrasib, Adagrasib, Adagrasib, Adagrasib, Pembrolizumab A Study Evaluating FMC-376 in Participants With KRAS G12C Mutated Solid Tumors NCT06244771Phase 1, Phase 226 sites๐Ÿ“ La Jolla๐Ÿ“ Orange๐Ÿ“ San Francisco Frontier Medicines Corporation ยท Tests: FMC-376 Open-label Study of BBO-8520 in Adult Subjects With KRASG12C Non-small Cell Lung Cancer NCT06343402Phase 138 sites๐Ÿ“ Birmingham๐Ÿ“ La Jolla๐Ÿ“ San Francisco TheRas, Inc., d/b/a BBOT (BridgeBio Oncology Therapeutics) ยท Tests: BBO-8520, Pembrolizumab, BBO-10203 A Study of ERAS-0015 in Patients With Advanced or Metastatic Solid Tumors NCT06983743Phase 19 sites๐Ÿ“ Santa Rosa๐Ÿ“ Aurora๐Ÿ“ Sarasota Erasca, Inc. ยท Tests: ERAS-0015, ERAS-0015 in combination Efficacy and Safety of IBI351 in Combination With Chemotherapy in Advanced Non-squamous Non-small Cell Lung Cancer Subjects With KRAS G12C Mutation NCT05504278Phase 11 site๐Ÿ“ Jilin City Innovent Biologics (Suzhou) Co. Ltd. ยท Tests: IBI351, Cetuximab, pemetrexed, Carboplatin, Sintilimab A Study of First-Line Olomorasib (LY3537982) and Pembrolizumab With or Without Chemotherapy in Patients With Advanced KRAS G12C-Mutant Non-small Cell Lung Cancer NCT06119581Phase 3416 sites๐Ÿ“ Huntsville๐Ÿ“ Gilbert๐Ÿ“ Phoenix Eli Lilly and Company ยท Tests: LY3537982, Pembrolizumab, Placebo, Cisplatin, Carboplatin A Clinical Study of MK-1084 With Other Treatments for Non-small Cell Lung Cancer (MK-3475-01F) NCT07286149Phase 1, Phase 229 sites๐Ÿ“ Clermont๐Ÿ“ Chicago๐Ÿ“ Portland Merck Sharp & Dohme LLC ยท Tests: MK-1084, Patritumab deruxtecan, Sacituzumab tirumotecan, Cetuximab, Rescue Medications A Study Evaluating the Efficacy and Safety of Divarasib and Pembrolizumab Versus Pembrolizumab and Pemetrexed and Carboplatin or Cisplatin in Participants With Previously Untreated, KRAS G12C-Mutated, Advanced or Metastatic Non-Squamous Non-Small Cell Lung Cancer NCT06793215Phase 3288 sites๐Ÿ“ Anchorage๐Ÿ“ Goodyear๐Ÿ“ Clovis Hoffmann-La Roche ยท Tests: Divarasib, Pembrolizumab, Pemetrexed, Carboplatin, Cisplatin A Study Evaluating the Safety, Activity, and Pharmacokinetics of Divarasib as a Single Agent or in Combination With Other Anti-Cancer Therapies in Participants With Previously Untreated Advanced or Metastatic Non-Small Cell Lung Cancer With a KRAS G12C Mutation NCT05789082Phase 1, Phase 271 sites๐Ÿ“ Duarte๐Ÿ“ Huntington Beach๐Ÿ“ Irvine Hoffmann-La Roche ยท Tests: Divarasib, Pembrolizumab, Carboplatin, Cisplatin, Pemetrexed A Study of Sotorasib in People With Non-Small Cell Lung Cancer NCT06582771Phase 27 sites๐Ÿ“ Basking Ridge๐Ÿ“ Middletown๐Ÿ“ Montvale Memorial Sloan Kettering Cancer Center ยท Tests: Sotorasib Study of Elironrasib and Daraxonrasib as Monotherapies and Combination Therapy in Participants With Advanced KRAS G12C Mutant Solid Tumors NCT06128551Phase 1, Phase 256 sites๐Ÿ“ Duarte๐Ÿ“ Orange๐Ÿ“ Sacramento Revolution Medicines, Inc. ยท Tests: Elironrasib, Daraxonrasib A Phase 3 Study of IN10018 in Combination With D-1553 Versus Standard Therapy for First Line Non-squamous Non-small Cell Lung Cancer With KRAS G12C Mutation NCT07174908Phase 311 sites๐Ÿ“ Beijing๐Ÿ“ Guangzhou๐Ÿ“ Zhengzhou InxMed (Shanghai) Co., Ltd. ยท Tests: IN10018 in combination with D-1553, anti-PD-1 monoclonal antibody in combination with platinum and pemetrexed Phase 1/2a Study of JAB-21822 Plus JAB-3312 in Patients With Advanced Solid Tumors Harboring KRAS p.G12C Mutation NCT05288205Phase 1, Phase 227 sites๐Ÿ“ Hefei๐Ÿ“ Beijing๐Ÿ“ Beijing Allist Pharmaceuticals, Inc. ยท Tests: JAB-21822, JAB-3312
๐Ÿ›ก๏ธ

AI Cure shows public evidence (Open Targets, ClinicalTrials.gov, PubMed, openFDA, DepMap, AlphaFold) with its source, and AI summaries that cite it โ€” not medical advice and not a cure. Treatment decisions belong with your doctor. Research ideas are shared only with approved researchers and labs, who can test them. In an emergency call your local emergency number (112 in India and Europe, 911 in the US). AI Cure Terms of Use ยท Privacy