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Trial Match

Clinical trials test new treatments — sometimes the newest options available for a disease. Find trials that are recruiting now, near you. Open one to see its eligibility rules as simple questions to go through with your doctor.

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30 recruiting trials

for Motor Neuron Diseases

Study of Safety, Tolerability and Efficacy of GB221 in Infants With Spinal Muscular Atrophy Type 1 NCT07070999Phase 1, Phase 21 site📍 Porto Alegre Gemma Biotherapeutics · Tests: GB221 Controlling Amyotrophic Lateral Sclerosis Motor Neuron Excitability Study NCT06649955NA1 site📍 Boston PathMaker Neurosystems Inc. · Tests: Multi-site direct current stimulation (DCS) Effects of Vagal Nerve Stimulation on Leg Muscle Activity and Posture in Parkinson's Disease NCT07226284NA1 site📍 Minneapolis University of Minnesota · Tests: Vagal nerve stimulation, No intervention Hypercaloric PEG Nutrition in ALS to Sustain Energy Homeostasis NCT06877143NA1 site📍 Ulm University of Ulm · Tests: 100% of individual calory requirement, 120% of individual calory requirement Investigation on the Cortical Communication System NCT06207591NA1 site📍 Utrecht UMC Utrecht · Tests: ECoG (electrocorticography) sensing Neurodegenerative Diseases Progression Markers (MARKERS-NDD) NCT06596746n/a1 site📍 Cassino Casa di Cura San Raffaele Cassino · Tests: Observation CuidAME: Longitudinal Data Collection From Patients With Spinal Muscular Atrophy in Spain NCT07231549n/a1 site📍 Esplugues de Llobregat Fundació Sant Joan de Déu Spinal Cord Associative Plasticity for ALS NCT06172621NA1 site📍 The Bronx VA Office of Research and Development · Tests: Spinal Cord Associative Plasticity (SCAP), Upper extremity task-oriented exercise A Study of LTX-002 in Adult Participants With Amyotrophic Lateral Sclerosis NCT07660614Phase 1, Phase 25 sites📍 Lübeck📍 Milan📍 Torino Leal Therapeutics, Inc · Tests: LTX-002, Placebo (aCSF) A Registered Cohort Study on Amyotrophic Lateral Sclerosis NCT04008329n/a1 site📍 Fuzhou First Affiliated Hospital of Fujian Medical University Clinical Study to Evaluate the Efficacy and Safety of FB1006 in the Treatment of ALS Patients NCT05923905Phase 41 site📍 Beijing Peking University Third Hospital · Tests: FB1006, Placebo Study of an Intrathecal Port and Catheter System for Subjects With Spinal Muscular Atrophy NCT05866419NA21 sites📍 Phoenix📍 Orange📍 Palo Alto Alcyone Therapeutics, Inc · Tests: ThecaFlex DRx System Safety, PK and Biodistribution of 18F-OP-801 in Patients With ALS, AD, MS, PD and Healthy Volunteers NCT05395624Phase 1, Phase 23 sites📍 San Francisco📍 Stanford📍 Jacksonville Ashvattha Therapeutics, Inc. · Tests: 18F-OP-801 Expression Profile Study of Macrophages From Patients Affected by ALS or Other Related Motor Impairments NCT04816227n/a1 site📍 Paris Institut National de la Santé Et de la Recherche Médicale, … Biospecimen Biorepository for the Study of ALS, ALS-FTD and Similar Neurodegenerative Disorders NCT05116943n/a1 site📍 Jacksonville Mayo Clinic Intermuscular Coherence as a Biomarker for ALS NCT05104710n/a4 sites📍 Irvine📍 Miami📍 Boston University of Chicago Investigating the Impact of Electrical Stimulation on Facial Pain, Jaw Movement and Oral Health in People With Motor Neuron Disease. NCT07187388NA1 site📍 Davie Nova Southeastern University · Tests: Transcutaneous Electrical Nerve Stimulation to reduce facial pain and improve jaw range of motion in ALS and PLS Motoneuron Recruitment and Motor Evoked Potential Up-Conditioning (MEP) in Spinal Cord Injury (SCI) NCT07179822NA1 site📍 Charleston Medical University of South Carolina · Tests: Motor Evoked Potential (MEP) Operant Conditioning Connect-One: Early Feasibility Study of Connexus® Brain-Computer Interface (BCI) NCT07357428NA3 sites📍 Sacramento📍 Boston📍 Ann Arbor Paradromics · Tests: Connexus Brain-Computer Interface Rare Disease Registry Database for Movement Disorders in Southern Anhui Province NCT07838883n/a1 site📍 Wuhu First Affiliated Hospital of Wannan Medical College Neural Stem Cell Treatment for Amyotrophic Lateral Sclerosis (STEMALS) NCT06344260Phase 24 sites📍 San Giovanni Rotondo📍 Novara📍 Padua Casa Sollievo della Sofferenza IRCCS · Tests: human Neural Stem Cells (hNSC), Saline (Placebo) Developing New Ways to Detect Respiratory Impairment Early in ALS NCT07844590n/a1 site📍 Philadelphia Thomas Jefferson University Investigation on the Cortical Communication (CortiCom) System NCT03567213NA1 site📍 Baltimore Johns Hopkins University · Tests: Surgical implantation of CortiCom system Biomarker-driven Phenotypic Dissection of Amyotrophic Lateral Sclerosis NCT06318598n/a3 sites📍 Milan📍 Milan📍 Torino Istituto Auxologico Italiano 7T Imaging Pilot-study in Patients With Motor Neuron Disease to Find Non-Invasive Disease Imaging Biomarkers NCT07818772n/a1 site📍 Glasgow NHS Greater Glasgow and Clyde · Tests: MRI Efficacy and Safety of Masitinib Versus Placebo in the Treatment of ALS Patients NCT03127267Phase 356 sites📍 Birmingham📍 Los Angeles📍 Lexington AB Science · Tests: Masitinib (6.0), Riluzole, Placebo, Masitinib (4.5) Advanced Multi-omics and -System Approaches to Identify Novel Biomarkers for SMA NCT07883655n/a3 sites📍 Genova📍 Milan📍 Naples Istituto Giannina Gaslini Spastic Paraplegia - Centers of Excellence Research Network NCT06553976n/a11 sites📍 Miami📍 Iowa City📍 Boston Boston Children's Hospital Gait and Bone Health in SMA NCT07400198n/a1 site📍 New York Jacqueline Montes Interfacing With NeuroTechnology to Expand Neural Throughput (INTENT) NCT07521930NA1 site📍 Baltimore Johns Hopkins University · Tests: INTENT Neural Interface System
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